{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T03:40:44Z","timestamp":1790394044256,"version":"4.1.0"},"reference-count":53,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2020,1,10]],"date-time":"2020-01-10T00:00:00Z","timestamp":1578614400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Neurol. Sci."],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>ABSTRACT:<\/jats:title><jats:sec id=\"S0317167120000086_as1\" sec-type=\"other\"><jats:title>Background:<\/jats:title><jats:p>Young-onset dementia (YOD) is defined as the onset of dementia symptoms before the age of 65 years and accounts for 2\u20138% of dementia. YOD patients and their caregivers face unique challenges in diagnosis and management. We aimed to compare the characteristics of rural YOD and late-onset dementia (LOD) patients at a rural and remote memory clinic in Western Canada.<\/jats:p><\/jats:sec><jats:sec id=\"S0317167120000086_as2\" sec-type=\"other\"><jats:title>Methods:<\/jats:title><jats:p>A total of 333 consecutive patients (YOD = 61, LOD = 272) at a rural and remote memory clinic between March 2004 and July 2016 were included in this study. Each patient had neuropsychological assessment. Health, mood, function, behaviour and social factors were also measured. Both groups were compared using <jats:italic>\u03c7<\/jats:italic><jats:sup>2<\/jats:sup> tests and independent sample tests.<\/jats:p><\/jats:sec><jats:sec id=\"S0317167120000086_as3\" sec-type=\"other\"><jats:title>Results:<\/jats:title><jats:p>YOD patients were more likely to be married, employed, current smokers and highly educated. They reported fewer cognitive symptoms, but had more depressive symptoms. YOD patients were less likely to live alone and use homecare services. YOD caregivers were also more likely to be a spouse and had higher levels of distress than LOD caregivers. Both YOD and LOD patient groups were equally likely to have a driver\u2019s licence.<\/jats:p><\/jats:sec><jats:sec id=\"S0317167120000086_as4\" sec-type=\"other\"><jats:title>Conclusions:<\/jats:title><jats:p>Our findings indicate YOD and LOD patients have distinct characteristics and services must be modified to better meet YOD patient needs. In particular, the use of homecare services and caregiver support may alleviate the higher levels of distress found in YOD patients and their caregivers. Additional research should be directed to addressing YOD patient depression, caregiver distress and barriers to services.<\/jats:p><\/jats:sec>","DOI":"10.1017\/cjn.2020.8","type":"journal-article","created":{"date-parts":[[2020,1,10]],"date-time":"2020-01-10T09:17:51Z","timestamp":1578647871000},"page":"320-327","source":"Crossref","is-referenced-by-count":16,"title":["Characteristics of Young-Onset and Late-Onset Dementia Patients at a Remote Memory Clinic"],"prefix":"10.1017","volume":"47","author":[{"given":"Jennifer F. W.","family":"Wong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Kirk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Landon","family":"Perlett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chandima","family":"Karunanayake","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debra","family":"Morgan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan E.","family":"O\u2019Connell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2020,1,10]]},"reference":[{"key":"S0317167120000086_ref10","doi-asserted-by":"publisher","DOI":"10.1159\/000488237"},{"key":"S0317167120000086_ref5","doi-asserted-by":"publisher","DOI":"10.1177\/1533317509333905"},{"key":"S0317167120000086_ref46","doi-asserted-by":"publisher","DOI":"10.1159\/000437299"},{"key":"S0317167120000086_ref44","unstructured":"44. Statistics Canada. Smokers, by age group; 2018. Retrieved from: https:\/\/www150.statcan.gc.ca\/t1\/tbl1\/en\/tv.action?pid=1310009610; accessed June 15, 2018."},{"key":"S0317167120000086_ref1","volume-title":"Prevalence and monetary costs of dementia in Canada","year":"2016"},{"key":"S0317167120000086_ref33","doi-asserted-by":"publisher","DOI":"10.1093\/geront\/43.1.121"},{"key":"S0317167120000086_ref22","doi-asserted-by":"publisher","DOI":"10.1017\/S0317167100015602"},{"key":"S0317167120000086_ref24","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3956(75)90026-6"},{"key":"S0317167120000086_ref32","volume-title":"The hidden victims of Alzheimer\u2019s disease: families under stress","author":"Zarit","year":"1985"},{"key":"S0317167120000086_ref34","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.48.5_Suppl_6.10S"},{"key":"S0317167120000086_ref47","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-170409"},{"key":"S0317167120000086_ref19","doi-asserted-by":"publisher","DOI":"10.1080\/13607860802154432"},{"key":"S0317167120000086_ref31","doi-asserted-by":"publisher","DOI":"10.1080\/01688638808402810"},{"key":"S0317167120000086_ref14","doi-asserted-by":"publisher","DOI":"10.1111\/psyg.12234"},{"key":"S0317167120000086_ref42","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)31363-6"},{"key":"S0317167120000086_ref17","unstructured":"17. Statistics Canada. Focus on Geography Series, 2016 Census; 2017. Retrieved from: https:\/\/www12.statcan.gc.ca\/census-recensement\/2016\/as-sa\/fogs-spg\/Facts-pr-eng.cfm?Lang=Eng&GK=PR&GC=47&TOPIC=1; accessed October 18, 2018."},{"key":"S0317167120000086_ref37","unstructured":"37. Quality metric health outcomes scoring software 4.5\u2013user\u2019s guide. Lincoln, RI: Quality Metric Incorporated; 2002."},{"key":"S0317167120000086_ref41","unstructured":"41. Statistics Canada. Hearing loss of Canadians, 2012 to 2015; 2016. Retrieved from: \u2013https:\/\/www150.statcan.gc.ca\/n1\/pub\/82\u2013625-x\/2016001\/article\/14658-eng.htm; accessed November 24, 2019."},{"key":"S0317167120000086_ref36","volume-title":"SF-36 physical and mental component summary measures\u2013a user\u2019s manual","author":"Ware","year":"1994"},{"key":"S0317167120000086_ref53","doi-asserted-by":"publisher","DOI":"10.1016\/j.maturitas.2019.01.003"},{"key":"S0317167120000086_ref27","doi-asserted-by":"publisher","DOI":"10.1093\/geronj\/37.3.323"},{"key":"S0317167120000086_ref35","volume-title":"How to score version 2 of the SF-12 health survey","author":"Ware","year":"2002"},{"key":"S0317167120000086_ref21","doi-asserted-by":"publisher","DOI":"10.1017\/S0317167100011884"},{"key":"S0317167120000086_ref18","unstructured":"18. Alzheimer Society of Canada. Dementia in Saskatchewan; 2017. Retrieved from: http:\/\/alzheimer.ca\/en\/sk\/Vote-Dementia-Care\/Dementia-SK; accessed August 14, 2018."},{"key":"S0317167120000086_ref7","doi-asserted-by":"publisher","DOI":"10.1177\/1471301218783542"},{"key":"S0317167120000086_ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.maturitas.2016.07.019"},{"key":"S0317167120000086_ref51","doi-asserted-by":"publisher","DOI":"10.1177\/1533317510385811"},{"key":"S0317167120000086_ref49","doi-asserted-by":"publisher","DOI":"10.1080\/13607861003713224"},{"key":"S0317167120000086_ref20","doi-asserted-by":"publisher","DOI":"10.1017\/cjn.2017.267"},{"key":"S0317167120000086_ref30","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/25.2.113"},{"key":"S0317167120000086_ref13","doi-asserted-by":"publisher","DOI":"10.1177\/1471301212474143"},{"key":"S0317167120000086_ref40","first-page":"433","article-title":"Fourth Canadian Consensus Conference on the diagnosis and treatment of dementia","volume":"60","author":"Moore","year":"2014","journal-title":"Can Fam Physician."},{"key":"S0317167120000086_ref15","doi-asserted-by":"publisher","DOI":"10.1177\/1533317513494443"},{"key":"S0317167120000086_ref4","doi-asserted-by":"publisher","DOI":"10.1080\/13607863.2018.1428935"},{"key":"S0317167120000086_ref25","doi-asserted-by":"publisher","DOI":"10.1017\/S0317167100009458"},{"key":"S0317167120000086_ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jagp.2015.07.005"},{"key":"S0317167120000086_ref28","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291700048017"},{"key":"S0317167120000086_ref43","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-33325-x"},{"key":"S0317167120000086_ref38","volume-title":"IBM SPSS statistics for Windows, version 22.0","year":"2013"},{"key":"S0317167120000086_ref16","doi-asserted-by":"publisher","DOI":"10.1017\/S1041610213001890"},{"key":"S0317167120000086_ref11","doi-asserted-by":"publisher","DOI":"10.1002\/gps.2439"},{"key":"S0317167120000086_ref45","unstructured":"45. Government of Canada. Canada Pension Plan \u2013 how much could you receive; 2018 https:\/\/www.canada.ca\/en\/services\/benefits\/publicpensions\/cpp\/cpp-benefit\/amount.html; accessed June 29, 2018."},{"key":"S0317167120000086_ref26","doi-asserted-by":"publisher","DOI":"10.1177\/014662167700100306"},{"key":"S0317167120000086_ref2","doi-asserted-by":"publisher","DOI":"10.1111\/imj.13099"},{"key":"S0317167120000086_ref48","volume-title":"A systematic evidence review of interventions for non-professional caregivers of individuals with dementia","author":"Goy","year":"2010"},{"key":"S0317167120000086_ref12","doi-asserted-by":"publisher","DOI":"10.1017\/S1041610217001806"},{"key":"S0317167120000086_ref23","doi-asserted-by":"publisher","DOI":"10.1177\/1533317516662334"},{"key":"S0317167120000086_ref39","unstructured":"39. Statistics Canada. Census metropolitan influenced zones: detailed definition; 2018. Retrieved from: https:\/\/www150.statcan.gc.ca\/n1\/pub\/92\u2013195-x\/2011001\/other-autre\/miz-zim\/def-eng.htm; accessed November 24, 2019."},{"key":"S0317167120000086_ref50","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0180935"},{"key":"S0317167120000086_ref52","doi-asserted-by":"publisher","DOI":"10.1017\/S1041610211001013"},{"key":"S0317167120000086_ref8","doi-asserted-by":"publisher","DOI":"10.1111\/jpm.12154"},{"key":"S0317167120000086_ref29","first-page":"21","article-title":"Quality of life in Alzheimer\u2019s disease: patient and caregiver reports","volume":"5","author":"Logsdon","year":"1999","journal-title":"J Ment Health Aging."},{"key":"S0317167120000086_ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2012.09.011"}],"container-title":["Canadian Journal of Neurological Sciences \/ Journal Canadien des Sciences Neurologiques"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0317167120000086","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,4,29]],"date-time":"2020-04-29T13:42:01Z","timestamp":1588167721000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0317167120000086\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,10]]},"references-count":53,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,5]]}},"alternative-id":["S0317167120000086"],"URL":"https:\/\/doi.org\/10.1017\/cjn.2020.8","relation":{},"ISSN":["0317-1671","2057-0155"],"issn-type":[{"value":"0317-1671","type":"print"},{"value":"2057-0155","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,10]]}}}