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There is growing evidence supporting the use of whole-plant CBD-rich extracts (containing THC and other cannabinoids) in the treatment of pediatric DRE. Based on our experiences and reports in the literature, we propose that, in patients who fail management with an initial trial of high-dose CBD-focused therapy, there may be a role for add-on THC-focused formulations.<\/jats:p>","DOI":"10.1017\/cjn.2021.151","type":"journal-article","created":{"date-parts":[[2021,6,29]],"date-time":"2021-06-29T06:17:54Z","timestamp":1624947474000},"page":"595-597","source":"Crossref","is-referenced-by-count":12,"title":["Potential Benefit of Add-on \u03949-Tetrahydrocannabinol in Pediatric Drug-Resistant Epilepsy: A Case Series"],"prefix":"10.1017","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7264-767X","authenticated-orcid":false,"given":"Magda","family":"Nowicki","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1291-8137","authenticated-orcid":false,"given":"Sandrine","family":"Bourgeois-Tardif","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7285-4035","authenticated-orcid":false,"given":"Patrick L.","family":"Diaz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8111-0484","authenticated-orcid":false,"given":"Francois Olivier","family":"Hebert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathalie T.","family":"Sanon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre-Olivier","family":"Champagne","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Major","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erick","family":"Sell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"Bitton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9024-150X","authenticated-orcid":false,"given":"Evan","family":"Lewis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4162-6096","authenticated-orcid":false,"given":"Alexander G.","family":"Weil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2021,6,29]]},"reference":[{"key":"S0317167121001517_ref9","first-page":"1","article-title":"Composition and use of cannabis extracts for childhood epilepsy in the australian community","volume":"8","author":"Suraev","year":"2018","journal-title":"Sci Rep."},{"key":"S0317167121001517_ref5","first-page":"2","article-title":"Cannabis for Pediatric Epilepsy","volume":"37","author":"Huntsman","year":"2020","journal-title":"J Clin Neurophysiol Off Publ Am Electroencephalogr Soc."},{"key":"S0317167121001517_ref8","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.00359"},{"key":"S0317167121001517_ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2016.11.006"},{"key":"S0317167121001517_ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2019.12.006"},{"key":"S0317167121001517_ref6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2011.01238.x"},{"key":"S0317167121001517_ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.braindev.2018.03.013"},{"key":"S0317167121001517_ref1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2017.00301"},{"key":"S0317167121001517_ref3","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.621"},{"key":"S0317167121001517_ref10","doi-asserted-by":"publisher","DOI":"10.1101\/212662"}],"container-title":["Canadian Journal of Neurological Sciences \/ Journal Canadien des Sciences Neurologiques"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0317167121001517","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,30]],"date-time":"2022-06-30T01:08:41Z","timestamp":1656551321000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0317167121001517\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,29]]},"references-count":10,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,7]]}},"alternative-id":["S0317167121001517"],"URL":"https:\/\/doi.org\/10.1017\/cjn.2021.151","relation":{},"ISSN":["0317-1671","2057-0155"],"issn-type":[{"value":"0317-1671","type":"print"},{"value":"2057-0155","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,29]]}}}