{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T23:48:57Z","timestamp":1767916137656,"version":"3.49.0"},"reference-count":33,"publisher":"Cambridge University Press (CUP)","issue":"4","license":[{"start":{"date-parts":[[2021,7,19]],"date-time":"2021-07-19T00:00:00Z","timestamp":1626652800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Neurol. Sci."],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract:<\/jats:title><jats:sec id=\"S0317167121001761_as1\"><jats:title>Background:<\/jats:title><jats:p>Aneurysmal subarachnoid hemorrhage (SAH) remains a devastating condition with a case fatality of 36% at 30 days. Risk factors for mortality in SAH patients include patient demographics and the severity of the neurological injury. Pre-existing conditions and non-neurological medical complications occurring during the index hospitalization are also risk factors for mortality in SAH. The magnitude of the effect on mortality of pre-existing conditions and medical complications, however, is less well understood. In this study, we aim to determine the effect of pre-existing conditions and medical complications on SAH mortality.<\/jats:p><\/jats:sec><jats:sec id=\"S0317167121001761_as2\"><jats:title>Methods:<\/jats:title><jats:p>For a 25% random sample of the Greater Montreal Region, we used discharge abstracts, physician billings, and death certificate records, to identify adult patients with a new diagnosis of non-traumatic SAH who underwent cerebral angiography or surgical clipping of an aneurysm between 1997 and 2014.<\/jats:p><\/jats:sec><jats:sec id=\"S0317167121001761_as3\"><jats:title>Results:<\/jats:title><jats:p>The one-year mortality rate was 14.76% (94\/637). Having \u22653 pre-existing conditions was associated with increased one-year mortality OR 3.74, 95% CI [1.25, 9.57]. Having 2, or \u22653 medical complications was associated with increased one-year mortality OR, 2.42 [95% CI 1.25\u20134.69] and OR, 2.69 [95% CI 1.43\u20135.07], respectively. Sepsis, respiratory failure, and cardiac arrhythmias were associated with increased one-year mortality. Having 1, 2, or \u22653 pre-existing conditions was associated with increased odds of having medical complications in hospital.<\/jats:p><\/jats:sec><jats:sec id=\"S0317167121001761_as4\"><jats:title>Conclusions:<\/jats:title><jats:p>Pre-existing conditions and in-hospital non-neurological medical complications are associated with increased one-year mortality in SAH. 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