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We sought to review the evidence for these manifestations.<\/jats:p><\/jats:sec><jats:sec id=\"S0317167121001803_as2\"><jats:title>Methods:<\/jats:title><jats:p>In this systematic review and meta-analysis, we compiled studies published until March 31, 2021 that examined non-respiratory HEENT, central, and peripheral nervous system presentations in COVID-19 patients. We included 477 studies for qualitative synthesis and 59 studies for meta-analyses.<\/jats:p><\/jats:sec><jats:sec id=\"S0317167121001803_as3\"><jats:title>Results:<\/jats:title><jats:p>Anosmia, ageusia, and conjunctivitis may precede typical upper\/lower respiratory symptoms. Central nervous system (CNS) manifestations include stroke and encephalopathy, potentially with brainstem or cranial nerve involvement. MRI studies support CNS para-\/postinfectious etiologies, but direct neuroinvasion seems very rare, with few cases detecting Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in the CNS. Peripheral nervous system (PNS) manifestations include muscle damage, Guillain\u2013Barre syndrome (GBS), and its variants. There was moderate-to-high study heterogeneity and risk of bias. In random-effects meta-analyses, anosmia\/ageusia was estimated to occur in 56% of COVID-19 patients (95% CI: 0.41\u20130.71, I2:99.9%), more commonly than in patients without COVID-19 (OR: 14.28, 95% CI: 8.39\u201324.29, I2: 49.0%). Neurological symptoms were estimated to occur in 36% of hospitalized patients (95% CI: 0.31\u20130.42, I2: 99.8%); ischemic stroke in 3% (95% CI: 0.03\u20130.04, I2: 99.2%), and GBS in 0.04% (0.033%\u20130.047%), more commonly than in patients without COVID-19 (OR[stroke]: 2.53, 95% CI: 1.16\u20135.50, I2: 76.4%; OR[GBS]: 3.43,1.15\u201310.25, I2: 89.1%).<\/jats:p><\/jats:sec><jats:sec id=\"S0317167121001803_as4\"><jats:title>Conclusions:<\/jats:title><jats:p>Current evidence is mostly from retrospective cohorts or series, largely in hospitalized or critically ill patients, not representative of typical community-dwelling patients. There remains a paucity of systematically gathered prospective data on neurological manifestations. Nevertheless, these findings support a high index of suspicion to identify HEENT\/neurological presentations in patients with known COVID-19, and to test for COVID-19 in patients with such presentations at risk of infection.<\/jats:p><\/jats:sec>","DOI":"10.1017\/cjn.2021.180","type":"journal-article","created":{"date-parts":[[2021,7,21]],"date-time":"2021-07-21T12:40:05Z","timestamp":1626871205000},"page":"514-531","source":"Crossref","is-referenced-by-count":12,"title":["Neurological and Head\/Eyes\/Ears\/Nose\/Throat Manifestations of COVID-19: A Systematic Review and Meta-Analysis"],"prefix":"10.1017","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5520-2070","authenticated-orcid":false,"given":"Aravind","family":"Ganesh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabella R.","family":"Reis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malavika","family":"Varma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David G.","family":"Patry","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lara J.","family":"Cooke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2021,7,21]]},"reference":[{"key":"S0317167121001803_ref18","doi-asserted-by":"publisher","DOI":"10.1186\/2049-3258-72-39"},{"key":"S0317167121001803_ref20","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-020-06252-9"},{"key":"S0317167121001803_ref100","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-020-09966-2"},{"key":"S0317167121001803_ref139","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.h2538"},{"key":"S0317167121001803_ref99","first-page":"202222","article-title":"Brain MRI findings in severe COVID-19: a retrospective observational study","volume":"0","author":"Kremer","journal-title":"Radiology."},{"key":"S0317167121001803_ref17","unstructured":"17. 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