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Sci."],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>ABSTRACT:<\/jats:title><jats:sec id=\"S0317167121001840_as1\"><jats:title>Background:<\/jats:title><jats:p>To investigate the relative contributions of cerebral cortex and basal ganglia to movement stopping, we tested the optimum combination Stop Signal Reaction Time (ocSSRT) and median visual reaction time (RT) in patients with Alzheimer\u2019s disease (AD) and Parkinson\u2019s disease (PD) and compared values with data from healthy controls.<\/jats:p><\/jats:sec><jats:sec id=\"S0317167121001840_as2\"><jats:title>Methods:<\/jats:title><jats:p>Thirty-five PD patients, 22 AD patients, and 29 healthy controls were recruited to this study. RT and ocSSRT were measured using a hand-held battery-operated electronic box through a stop signal paradigm.<\/jats:p><\/jats:sec><jats:sec id=\"S0317167121001840_as3\"><jats:title>Result:<\/jats:title><jats:p>The mean ocSSRT was found to be 309 ms, 368 ms, and 265 ms in AD, PD, and healthy controls, respectively, and significantly prolonged in PD compared to healthy controls (<jats:italic>p<\/jats:italic> = 0.001). The ocSSRT but not RT could separate AD from PD patients (<jats:italic>p<\/jats:italic> = 0.022).<\/jats:p><\/jats:sec><jats:sec id=\"S0317167121001840_as4\"><jats:title>Conclusion:<\/jats:title><jats:p>Our data suggest that subcortical networks encompassing dopaminergic pathways in the basal ganglia play a more important role than cortical networks in movement-stopping. Combining ocSSRT with other putative indices or biomarkers of AD (and other dementias) could increase the accuracy of early diagnosis.<\/jats:p><\/jats:sec>","DOI":"10.1017\/cjn.2021.184","type":"journal-article","created":{"date-parts":[[2021,7,29]],"date-time":"2021-07-29T06:01:28Z","timestamp":1627538488000},"page":"662-671","source":"Crossref","is-referenced-by-count":9,"title":["Comparing Stop Signal Reaction Times in Alzheimer\u2019s and Parkinson\u2019s Disease"],"prefix":"10.1017","volume":"49","author":[{"given":"Simin","family":"Rahman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ummatul","family":"Siddique","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Supriyo","family":"Choudhury","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nazrul","family":"Islam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akash","family":"Roy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Purba","family":"Basu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sidharth Shankar","family":"Anand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Ariful","family":"Islam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Selim","family":"Shahi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abu","family":"Nayeem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md Tauhidul Islam","family":"Chowdhury","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Shah Jahirul Hoque","family":"Chowdhury","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John-Paul","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark R.","family":"Baker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart N.","family":"Baker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9789-7832","authenticated-orcid":false,"given":"Hrishikesh","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2021,7,29]]},"reference":[{"key":"S0317167121001840_ref44","doi-asserted-by":"publisher","DOI":"10.1007\/s00221-011-2736-6"},{"key":"S0317167121001840_ref12","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.46323"},{"key":"S0317167121001840_ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.brs.2020.09.007"},{"key":"S0317167121001840_ref11","first-page":"189","volume-title":"Inhibitory processes in attention, memory, and language","author":"Logan","year":"1994"},{"key":"S0317167121001840_ref28","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1098\/rstb.1996.0131","article-title":"Dissociating executive functions of the prefrontal cortex","volume":"351","author":"Robbins","year":"1996","journal-title":"Philos Trans R Soc Lond B Biol Sci."},{"key":"S0317167121001840_ref23","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.17.5.427"},{"key":"S0317167121001840_ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2014.11.017"},{"key":"S0317167121001840_ref46","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0519-07.2007"},{"key":"S0317167121001840_ref2","first-page":"241","volume-title":"Inhibitory processes in attention, memory, and language","author":"Zacks","year":"1994"},{"key":"S0317167121001840_ref62","doi-asserted-by":"publisher","DOI":"10.1076\/jcen.24.4.503.1034"},{"key":"S0317167121001840_ref32","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhk031"},{"key":"S0317167121001840_ref21","first-page":"165","article-title":"Parkinson\u2019s Disease Society Brain Bank, London: overview and research","volume":"39","author":"Daniel","year":"1993","journal-title":"J Neural Transm Suppl."},{"key":"S0317167121001840_ref1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-012208930-5\/50006-4"},{"key":"S0317167121001840_ref38","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.14.8301"},{"key":"S0317167121001840_ref22","unstructured":"22. 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