{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T01:19:25Z","timestamp":1779931165588,"version":"3.53.1"},"reference-count":25,"publisher":"Cambridge University Press (CUP)","issue":"5","license":[{"start":{"date-parts":[[2021,8,6]],"date-time":"2021-08-06T00:00:00Z","timestamp":1628208000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Neurol. Sci."],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>ABSTRACT:<\/jats:title><jats:sec id=\"S0317167121001906_as1\"><jats:title>Background:<\/jats:title><jats:p>Caring for women with epilepsy (WWE) during pregnancy poses unique challenges. We conducted an audit of the care our epilepsy clinic provided to pregnant WWE.<\/jats:p><\/jats:sec><jats:sec id=\"S0317167121001906_as2\"><jats:title>Methods:<\/jats:title><jats:p>We performed a retrospective study on all pregnancies followed by an epileptologist at a Canadian tertiary care centre\u2019s epilepsy clinic between January 2003 and March 2021. Among 81 pregnancies in 53 patients, 72 pregnancies in 50 patients were analyzed to determine patient-related, follow-up-related, antiseizure-medication-related, and child-related pregnancy characteristics. Univariate analyses were performed to explore if these characteristics were associated with disabling seizure occurrence during pregnancy.<\/jats:p><\/jats:sec><jats:sec id=\"S0317167121001906_as3\"><jats:title>Results:<\/jats:title><jats:p>Most pregnancies were intended (72%) and occurred in women who used folic acid pre-pregnancy (76%) and who followed recommended blood tests for antiseizure medication (ASM) levels (71%). In 49% of pregnancies, ASM dosage was modified; 53% of these modifications were made in response to ASM blood levels. Most often used ASMs were lamotrigine (43%), followed by carbamazepine (32%) and levetiracetam (13%). One child was born with a thyroglossal duct cyst; our congenital malformation rate was thus 2%. Disabling seizures occurred in 24% of pregnancies. Exploratory analyses suggested that disabling seizure occurrence during pregnancy was associated with younger patient age (p = 0.018), higher number of ASMs used during pregnancy (p = 0.048), lamotrigine usage in polytherapy (p = 0.008), and disabling seizure occurrence pre-pregnancy (p = 0.027).<\/jats:p><\/jats:sec><jats:sec id=\"S0317167121001906_as4\"><jats:title>Conclusion:<\/jats:title><jats:p>This Canadian audit provides an in-depth description of pregnancies benefiting from specialized epilepsy care. Our results suggest an association between disabling seizure occurrence during pregnancy and lamotrigine usage in polytherapy that warrants further evaluation.<\/jats:p><\/jats:sec>","DOI":"10.1017\/cjn.2021.190","type":"journal-article","created":{"date-parts":[[2021,8,6]],"date-time":"2021-08-06T05:38:17Z","timestamp":1628228297000},"page":"678-687","source":"Crossref","is-referenced-by-count":9,"title":["Epilepsy and Pregnancy: An Audit of Specialized Care"],"prefix":"10.1017","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8386-8897","authenticated-orcid":false,"given":"Jimmy","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7446-0312","authenticated-orcid":false,"given":"D\u00e8nahin Hinnoutondji","family":"Toffa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dang Khoa","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2021,8,6]]},"reference":[{"key":"S0317167121001906_ref5","doi-asserted-by":"publisher","DOI":"10.3310\/hta22230"},{"key":"S0317167121001906_ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.ncl.2018.09.008"},{"key":"S0317167121001906_ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2015.02.020"},{"key":"S0317167121001906_ref15","unstructured":"15. 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Report on New Patented Drugs - Keppra. Reports on new patented drugs for human use; 2014. Available at: http:\/\/www.pmprb-cepmb.gc.ca\/view.asp?ccid=622; accessed 2021."},{"key":"S0317167121001906_ref7","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.63.6.694"},{"key":"S0317167121001906_ref11","first-page":"CD010224","article-title":"Monotherapy treatment of epilepsy in pregnancy: congenital malformation outcomes in the child","volume":"11","author":"Weston","year":"2016","journal-title":"Cochrane Database Syst Rev"},{"key":"S0317167121001906_ref9","unstructured":"9. Holmes, L , Hernandez-Diaz, S , Quinn, M , Guillen, J , Weidman-Dahl, F , Coleman, C. The NA AED pregnancy registry AES; 2020. 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