{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T03:17:30Z","timestamp":1781752650200,"version":"3.54.5"},"reference-count":41,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2022,2,22]],"date-time":"2022-02-22T00:00:00Z","timestamp":1645488000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Neurol. Sci."],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>ABSTRACT:<\/jats:title><jats:sec id=\"S0317167122000191_as1\"><jats:title>Background:<\/jats:title><jats:p>The early clinical predictors of respiratory failure in Latin Americans with Guillain\u2013Barr\u00e9 syndrome (GBS) have scarcely been studied. This is of particular importance since Latin America has a high frequency of axonal GBS variants that may imply a worse prognosis.<\/jats:p><\/jats:sec><jats:sec id=\"S0317167122000191_as2\"><jats:title>Methods:<\/jats:title><jats:p>We studied 86 Mexican patients with GBS admitted to the<jats:italic>Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n<\/jats:italic>, a referral center of Mexico City, to describe predictors of invasive mechanical ventilation (IMV).<\/jats:p><\/jats:sec><jats:sec id=\"S0317167122000191_as3\"><jats:title>Results:<\/jats:title><jats:p>The median age was 40 years (interquartile range: 26\u201353.5), with 60.5% men (male-to-female ratio: 1.53). Most patients (65%) had an infectious antecedent (40.6% gastrointestinal). At admission, 38% of patients had a Medical Research Council (MRC) sum score &lt;30. Axonal subtypes predominated (60.5%), with acute motor axonal neuropathy being the most prevalent (34.9%), followed by acute inflammatory demyelinating polyneuropathy (32.6%), acute motor sensory axonal neuropathy (AMSAN) (25.6%), and Fisher syndrome (7%). Notably, 15.1% had onset in upper limbs, 75.6% dysautonomia, and 73.3% pain. In all, 86% received either IVIg (9.3%) or plasma exchange (74.4%). IMV was required in 39.5% patients (72.7% in AMSAN). A multivariate model without including published prognostic scores yielded the time since onset to admission &lt;15 days, axonal variants, MRC sum score &lt;30, and bulbar weakness as independent predictors of IMV. The model including grading scales yielded lower limbs onset, Erasmus GBS respiratory insufficiency score (EGRIS) &gt;4, and dysautonomia as predictors.<\/jats:p><\/jats:sec><jats:sec id=\"S0317167122000191_as4\"><jats:title>Conclusion:<\/jats:title><jats:p>These results suggest that EGRIS is a good prognosticator of IMV in GBS patients with a predominance of axonal electrophysiological subtypes, but other early clinical data should also be considered.<\/jats:p><\/jats:sec>","DOI":"10.1017\/cjn.2022.19","type":"journal-article","created":{"date-parts":[[2022,2,22]],"date-time":"2022-02-22T09:59:25Z","timestamp":1645523965000},"page":"221-227","source":"Crossref","is-referenced-by-count":7,"title":["Predictors of Mechanical Ventilation in Guillain\u2013Barr\u00e9 Syndrome with Axonal Subtypes"],"prefix":"10.1017","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9145-7433","authenticated-orcid":false,"given":"Anaclara","family":"Michel-Ch\u00e1vez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1142-295X","authenticated-orcid":false,"given":"Erwin","family":"Chiquete","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2685-6803","authenticated-orcid":false,"given":"Alfonso","family":"Gul\u00edas-Herrero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2436-9406","authenticated-orcid":false,"given":"Diego 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