{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T21:45:16Z","timestamp":1747172716398,"version":"3.40.5"},"reference-count":44,"publisher":"Cambridge University Press (CUP)","issue":"4","license":[{"start":{"date-parts":[[2022,6,20]],"date-time":"2022-06-20T00:00:00Z","timestamp":1655683200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Neurol. Sci."],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>ABSTRACT:<\/jats:title><jats:sec id=\"S0317167122002645_as1\"><jats:title>Objective:<\/jats:title><jats:p>To characterize 1) the relationship between laxative use and objective sleep metrics, and 2) the relationship between laxative use and self-reported insomnia symptoms in a convenience sample of middle-aged\/elderly patients who completed in-laboratory polysomnography.<\/jats:p><\/jats:sec><jats:sec id=\"S0317167122002645_as2\"><jats:title>Methods:<\/jats:title><jats:p>We cross-sectionally analyzed first-night diagnostic in-laboratory polysomnography data for 2946 patients over the age of 40 (mean age 60.5 years; 48.3% male). Laxative use and medical comorbidities were obtained through self-reported questionnaires. Patient insomnia symptoms were based on self-report. Associations between laxative use and objective sleep continuity were analyzed using multivariable linear regression models. Associations between laxative use and insomnia were assessed using multivariable logistic regression models.<\/jats:p><\/jats:sec><jats:sec id=\"S0317167122002645_as3\"><jats:title>Results:<\/jats:title><jats:p>After adjusting for age, sex, body mass index, total recording time, and relevant comorbidities, laxative users had a 7.1% lower sleep efficiency (<jats:italic>p<\/jats:italic> &lt; 0.001), 25.5-minute higher wake after sleep onset (<jats:italic>p<\/jats:italic> &lt; 0.001), and a 29.4-minute lower total sleep time (<jats:italic>p<\/jats:italic> &lt; 0.001) than patients not using laxatives. Laxative users were found to be at greater odds of reporting insomnia symptoms (OR = 1.7, <jats:italic>p<\/jats:italic> = 0.024) than patients not using laxatives.<\/jats:p><\/jats:sec><jats:sec id=\"S0317167122002645_as4\"><jats:title>Conclusion:<\/jats:title><jats:p>Laxative use is associated with impairments in objective sleep continuity. Patients using laxatives were also at greater odds of reporting insomnia symptoms.<\/jats:p><\/jats:sec>","DOI":"10.1017\/cjn.2022.264","type":"journal-article","created":{"date-parts":[[2022,6,20]],"date-time":"2022-06-20T10:16:59Z","timestamp":1655720219000},"page":"597-603","source":"Crossref","is-referenced-by-count":0,"title":["Laxatives are Associated with Poorer Polysomnography-derived Sleep Quality"],"prefix":"10.1017","volume":"50","author":[{"given":"Yakdehikandage S.","family":"Costa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian J.","family":"Murray","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9547-1889","authenticated-orcid":false,"given":"Mark I.","family":"Boulos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2022,6,20]]},"reference":[{"key":"S0317167122002645_ref32","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4757-3462-1"},{"key":"S0317167122002645_ref2","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2015.67"},{"key":"S0317167122002645_ref15","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(20)31675-9"},{"key":"S0317167122002645_ref11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2007.03376.x"},{"key":"S0317167122002645_ref38","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.2013.833605"},{"key":"S0317167122002645_ref29","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2011.30"},{"key":"S0317167122002645_ref18","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2008.01181.x"},{"key":"S0317167122002645_ref25","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.74.1.13"},{"key":"S0317167122002645_ref36","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(19)30246-8"},{"key":"S0317167122002645_ref22","doi-asserted-by":"publisher","DOI":"10.1186\/1471-230X-8-5"},{"key":"S0317167122002645_ref16","doi-asserted-by":"publisher","DOI":"10.1038\/s41746-021-00391-x"},{"key":"S0317167122002645_ref26","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.26.5.1553"},{"volume-title":"U.S. Department of Agriculture and U.S. Department of Health and Human Services","year":"2015","key":"S0317167122002645_ref5"},{"key":"S0317167122002645_ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpg.2009.09.001"},{"key":"S0317167122002645_ref31","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/zsaa096"},{"key":"S0317167122002645_ref37","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2016-311835"},{"key":"S0317167122002645_ref39","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v16.i43.5435"},{"key":"S0317167122002645_ref40","doi-asserted-by":"publisher","DOI":"10.1136\/gut.29.9.1173"},{"key":"S0317167122002645_ref8","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0000000000001333"},{"key":"S0317167122002645_ref41","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-199810000-00006"},{"key":"S0317167122002645_ref20","first-page":"17","article-title":"The AASM manual for the scoring of sleep and associated events: rules, terminology and technical specifications","author":"Iber","year":"2007","journal-title":"Am Acad Sleep Med"},{"key":"S0317167122002645_ref43","unstructured":"43. 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