{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T16:27:42Z","timestamp":1787243262186,"version":"build-2736575974"},"reference-count":23,"publisher":"Cambridge University Press (CUP)","issue":"5","license":[{"start":{"date-parts":[[2022,8,18]],"date-time":"2022-08-18T00:00:00Z","timestamp":1660780800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Neurol. Sci."],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>ABSTRACT:<\/jats:title>\n                  <jats:sec id=\"S0317167122002888_as1\">\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Half of Guillain\u2013Barr\u00e9 syndrome (GBS) present elevated cerebrospinal fluid (CSF) protein levels within 1 week since symptom onset and 80% within 2 weeks. Our objective was to determine the clinical and prognostic implication of albuminocytological dissociation in early GBS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0317167122002888_as2\">\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>An ambispective cohort study was conducted. Good outcome was considered if the patient was able to walk unaided (Guillain-Barr\u00e9 disability score [GDS] \u2264 2 points) at 3-month follow-up. Patients were classified into two groups: with and without albuminocytological dissociation; we compared clinical and paraclinic characteristics between the groups. We analyzed clinical and electrophysiological factors related to presenting early dissociation through a multivariate model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0317167122002888_as3\">\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      We included 240 patients who fulfilled Asbury criteria for GBS. On further selection, only 94 patients fulfilled inclusion. Mean age was 45.94 \u00b1 17.1 years and 67% were male. Median time from symptom onset to admission was 5 days (IQR 3\u20136). Regarding albuminocytological dissociation and electrophysiological variants, we found a significant difference: acute inflammatory demyelinating polyneuropathy (AIDP) [60.6% vs 26.2%,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.002], acute motor axonal neuropathy (AMAN) [21.2% vs 49.1%,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.009] and acute motor sensory axonal neuropathy (AMSAN) [12.1% vs 1.6%,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.05]. We did not observe significant differences in recovery of independent walking in short term between both groups. The presence of conduction block in any variant (OR 3.21, 95% CI 1.12\u20139.16,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.02) and absence of sural registration (OR 5.69, 95% CI 1.48\u201321.83,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.011) were independent factors related to early dissociation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0317167122002888_as4\">\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Early dissociation (&lt;7 days) is not associated with any particular clinical feature or unfavorable outcome. It is more common to see in AIDP rather than axonal variants.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/cjn.2022.288","type":"journal-article","created":{"date-parts":[[2022,8,18]],"date-time":"2022-08-18T03:16:11Z","timestamp":1660792571000},"page":"745-750","source":"Crossref","is-referenced-by-count":6,"title":["Prognostic Implications of Early Albuminocytological Dissociation in Guillain\u2013Barr\u00e9 Syndrome"],"prefix":"10.1017","volume":"50","author":[{"given":"Edwin Steven","family":"Vargas-Ca\u00f1as","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3004-6221","authenticated-orcid":false,"given":"Javier Andr\u00e9s","family":"Galnares-Olalde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fausto","family":"Le\u00f3n-Velasco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5287-1068","authenticated-orcid":false,"given":"Miguel","family":"Garc\u00eda-Grimshaw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alonso","family":"Guti\u00e9rrez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3419-5160","authenticated-orcid":false,"given":"Juan Carlos","family":"L\u00f3pez-Hern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2022,8,18]]},"reference":[{"key":"S0317167122002888_ref10","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(78)92644-2"},{"key":"S0317167122002888_ref20","doi-asserted-by":"publisher","DOI":"10.1017\/cjn.2022.19"},{"key":"S0317167122002888_ref16","doi-asserted-by":"publisher","DOI":"10.4081\/ni.2017.7032"},{"key":"S0317167122002888_ref5","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-016-8204-2"},{"key":"S0317167122002888_ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2018.09.025"},{"key":"S0317167122002888_ref6","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1002\/ana.21976","article-title":"Prediction of respiratory insufficiency in Guillain-Barr\u00e9 syndrome","volume":"67","author":"Walgaard","year":"2010","journal-title":"Ann 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