{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T21:45:20Z","timestamp":1747172720072,"version":"3.40.5"},"reference-count":30,"publisher":"Cambridge University Press (CUP)","issue":"5","license":[{"start":{"date-parts":[[2022,11,14]],"date-time":"2022-11-14T00:00:00Z","timestamp":1668384000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Neurol. Sci."],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>ABSTRACT:<\/jats:title><jats:sec id=\"S0317167122003006_as1\"><jats:title>Background:<\/jats:title><jats:p>Despite its effectiveness, surgery for drug-resistant epilepsy is underutilized. However, whether epilepsy surgery is also underutilized among patients with stroke-related drug-resistant epilepsy is unclear. Therefore, our objectives were to estimate the rates of epilepsy surgery assessment and receipt among patients with stroke-related drug-resistant epilepsy and to identify factors associated with these outcomes.<\/jats:p><\/jats:sec><jats:sec id=\"S0317167122003006_as2\"><jats:title>Methods:<\/jats:title><jats:p>We used linked health administrative databases to conduct a population-based retrospective cohort study of adult Ontario, Canada residents discharged from an Ontario acute care institution following the treatment of a stroke between January 1, 1997, and December 31, 2020, without prior evidence of seizures. We excluded patients who did not subsequently develop drug-resistant epilepsy and those with other epilepsy risk factors. We estimated the rates of epilepsy surgery assessment and receipt by March 31, 2021. We planned to use Fine-Gray subdistribution hazard models to identify covariates independently associated with our outcomes, controlling for the competing risk of death.<\/jats:p><\/jats:sec><jats:sec id=\"S0317167122003006_as3\"><jats:title>Results:<\/jats:title><jats:p>We identified 265,081 patients who survived until discharge following inpatient stroke treatment, 1,902 (0.7%) of whom subsequently developed drug-resistant epilepsy (805 women; mean age: 67.0\u00a0\u00b1\u00a013.1 years). Fewer than six (\u22640.3%) of these patients were assessed for or received epilepsy surgery before the end of follow-up (\u226455.5 per 100,000 person-years). Given that few outcomes were identified, we could not proceed with the multivariable analyses.<\/jats:p><\/jats:sec><jats:sec id=\"S0317167122003006_as4\"><jats:title>Conclusions:<\/jats:title><jats:p>Patients with stroke-related drug-resistant epilepsy are infrequently considered for epilepsy surgery that could reduce morbidity and mortality.<\/jats:p><\/jats:sec>","DOI":"10.1017\/cjn.2022.300","type":"journal-article","created":{"date-parts":[[2022,11,14]],"date-time":"2022-11-14T08:24:14Z","timestamp":1668414254000},"page":"673-678","source":"Crossref","is-referenced-by-count":0,"title":["Epilepsy Surgery in Adult Stroke Survivors with New-Onset Drug-Resistant Epilepsy"],"prefix":"10.1017","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8612-5976","authenticated-orcid":false,"given":"Tresah C.","family":"Antaya","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Britney N.","family":"Le","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6577-5067","authenticated-orcid":false,"given":"Lucie","family":"Richard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amna","family":"Qureshi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1219-6763","authenticated-orcid":false,"given":"Salimah Z.","family":"Shariff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6425-9343","authenticated-orcid":false,"given":"Luciano A.","family":"Sposato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3644-2826","authenticated-orcid":false,"given":"Jorge G.","family":"Burneo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2022,11,14]]},"reference":[{"key":"S0317167122003006_ref13","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-802997-8.00016-5"},{"key":"S0317167122003006_ref12","unstructured":"12. Queens Printer for Ontario. Get coverage for prescription drugs [Internet]. 2020 [cited 2020 Aug 12]. Available at: https:\/\/www.ontario.ca\/page\/get-coverage-prescription-drugs."},{"key":"S0317167122003006_ref5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2011.03213.x"},{"key":"S0317167122003006_ref27","doi-asserted-by":"publisher","DOI":"10.1159\/000449288"},{"key":"S0317167122003006_ref21","doi-asserted-by":"publisher","DOI":"10.3171\/2014.3.PEDS13440"},{"key":"S0317167122003006_ref23","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)33064-8"},{"key":"S0317167122003006_ref1","doi-asserted-by":"publisher","DOI":"10.1179\/1074935715Z.00000000062"},{"key":"S0317167122003006_ref7","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(06)70448-3"},{"key":"S0317167122003006_ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuro.2016.03.011"},{"key":"S0317167122003006_ref11","unstructured":"11. Statistics Canada. Population by year, by province and territory (number), CANSIM table 051-0001 [Internet]. 2017 [cited 2018 Apr 9]. Available at: http:\/\/www.statcan.gc.ca\/tables-tableaux\/sum-som\/l01\/cst01\/demo02a-eng.htm."},{"key":"S0317167122003006_ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2014.05.018"},{"key":"S0317167122003006_ref9","first-page":"538","article-title":"Practice parameter: temporal lobe and localized neocortical resections for epilepsy","volume":"60","author":"Engel","year":"2003","journal-title":"Am Acad Neurol."},{"key":"S0317167122003006_ref28","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2012.05.009"},{"key":"S0317167122003006_ref8","first-page":"e500","article-title":"Clinical outcomes and quality of life following surgical treatment for refractory epilepsy: a systematic review and meta-analysis","volume":"94","author":"Liu","year":"2015","journal-title":"Medicine (United States)"},{"key":"S0317167122003006_ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2004.05.004"},{"key":"S0317167122003006_ref3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2009.02739.x"},{"key":"S0317167122003006_ref2","doi-asserted-by":"publisher","DOI":"10.1111\/ane.12070"},{"key":"S0317167122003006_ref4","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000007895"},{"key":"S0317167122003006_ref18","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000285084.93652.43"},{"key":"S0317167122003006_ref24","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2008.02.003"},{"key":"S0317167122003006_ref26","doi-asserted-by":"publisher","DOI":"10.1159\/000015960"},{"key":"S0317167122003006_ref30","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2015.07.007"},{"key":"S0317167122003006_ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2019.106155"},{"key":"S0317167122003006_ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2016.10.026"},{"key":"S0317167122003006_ref10","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000002249"},{"key":"S0317167122003006_ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2005.07.016"},{"key":"S0317167122003006_ref25","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000001127"},{"key":"S0317167122003006_ref29","first-page":"24","volume-title":"Risk factors. 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