{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T06:03:50Z","timestamp":1792389830630,"version":"4.4.0"},"reference-count":89,"publisher":"Cambridge University Press (CUP)","issue":"4","license":[{"start":{"date-parts":[[2022,5,26]],"date-time":"2022-05-26T00:00:00Z","timestamp":1653523200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Neurol. Sci."],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>ABSTRACT:<\/jats:title><jats:sec id=\"S0317167122000658_as1\"><jats:title>Background:<\/jats:title><jats:p>A large proportion of Alzheimer\u2019s disease (AD) patients have coexisting subcortical vascular dementia (SVaD), a condition referred to as mixed dementia (MixD). Brain imaging features of MixD presumably include those of cerebrovascular disease and AD pathology, but are difficult to characterize due to their heterogeneity.<\/jats:p><\/jats:sec><jats:sec id=\"S0317167122000658_as2\"><jats:title>Objective:<\/jats:title><jats:p>To perform an exploratory analysis of conventional and non-conventional structural magnetic resonance imaging (MRI) abnormalities in MixD and to compare them to those observed in AD and SVaD.<\/jats:p><\/jats:sec><jats:sec id=\"S0317167122000658_as3\"><jats:title>Methods:<\/jats:title><jats:p>We conducted a cross-sectional, region-of-interest-based analysis of 1) hyperintense white-matter signal abnormalities (WMSA) on T2-FLAIR and hypointense WMSA on T1-weighted MRI; 2) diffusion tensor imaging; 3) quantitative susceptibility mapping; and 4) effective transverse relaxation rate (R2*) in N = 17 participants (AD:5, SVaD:5, MixD:7). General linear model was used to explore group differences in these brain imaging measures.<\/jats:p><\/jats:sec><jats:sec id=\"S0317167122000658_as4\"><jats:title>Results:<\/jats:title><jats:p>Model findings suggested imaging characteristics specific to our MixD group, including 1) higher burden of WMSAs on T1-weighted MRI (versus both AD and SVaD); 2) frontal lobar preponderance of WMSAs on both T2-FLAIR and T1-weighted MRI; 3) higher fractional anisotropy values within normal-appear white-matter tissues (versus SVaD, but not AD); and 4) lower R2* values within the T2-FLAIR WMSA areas (versus both AD and SVaD).<\/jats:p><\/jats:sec><jats:sec id=\"S0317167122000658_as5\"><jats:title>Conclusion:<\/jats:title><jats:p>These findings suggest a preliminary picture of the location and type of brain imaging characteristics associated with MixD. Future imaging studies may employ region-specific hypotheses to distinguish MixD more rigorously from AD or SVaD.<\/jats:p><\/jats:sec>","DOI":"10.1017\/cjn.2022.65","type":"journal-article","created":{"date-parts":[[2022,5,26]],"date-time":"2022-05-26T03:26:35Z","timestamp":1653535595000},"page":"515-528","source":"Crossref","is-referenced-by-count":7,"title":["Brain Imaging Abnormalities in Mixed Alzheimer\u2019s and Subcortical Vascular Dementia"],"prefix":"10.1017","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8598-9123","authenticated-orcid":false,"given":"Hyunwoo","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa","family":"Wiggermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Rauscher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Kames","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirza Faisal","family":"Beg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karteek","family":"Popuri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger","family":"Tam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Lam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Jacova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elham","family":"Shahinfard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vesna","family":"Sossi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline A.","family":"Pettersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ging-Yuek Robin","family":"Hsiung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2022,5,26]]},"reference":[{"key":"S0317167122000658_ref82","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2018.06.004"},{"key":"S0317167122000658_ref25","doi-asserted-by":"publisher","DOI":"10.1258\/ar.2011.110272"},{"key":"S0317167122000658_ref47","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2002.1132"},{"key":"S0317167122000658_ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2013.05.011"},{"key":"S0317167122000658_ref80","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awx137"},{"key":"S0317167122000658_ref61","doi-asserted-by":"publisher","DOI":"10.1186\/alzrt93"},{"key":"S0317167122000658_ref84","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2015.05.006"},{"key":"S0317167122000658_ref8","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0075602"},{"key":"S0317167122000658_ref1","doi-asserted-by":"crossref","unstructured":"1. 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