{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T21:45:35Z","timestamp":1747172735341,"version":"3.40.5"},"reference-count":31,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2023,2,15]],"date-time":"2023-02-15T00:00:00Z","timestamp":1676419200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Neurol. Sci."],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>ABSTRACT:<\/jats:title><jats:sec id=\"S0317167123000239_as1\"><jats:title>Background:<\/jats:title><jats:p>Up to 30% of patients with Guillain\u2013Barr\u00e9 syndrome require mechanical ventilation and 5% die due to acute complications of mechanical ventilation. There is a considerable group of patients that will need prolonged mechanical ventilation (considered as &gt;14 days) and should be considered for early tracheostomy. The objective of this study is to identify risk factors for prolonged mechanical ventilation.<\/jats:p><\/jats:sec><jats:sec id=\"S0317167123000239_as2\"><jats:title>Methods:<\/jats:title><jats:p>We prospectively analyzed patients with Guillain\u2013Barr\u00e9 diagnosis with versus without prolonged mechanical ventilation. We considered clinical and electrophysiological characteristics and analyzed factors associated with prolonged mechanical ventilation.<\/jats:p><\/jats:sec><jats:sec id=\"S0317167123000239_as3\"><jats:title>Results:<\/jats:title><jats:p>Three hundred and three patients were included; 29% required mechanical ventilation. When comparing the groups, patients with prolonged invasive mechanical ventilation (IMV) have a lower score on the Medical Research Council score (19.5 \u00b1 16.2 vs 27.4 \u00b1 17.5, <jats:italic>p<\/jats:italic> = 0.03) and a higher frequency of dysautonomia (42.3% vs 19.4%, <jats:italic>p<\/jats:italic> = 0.037), as well as lower amplitudes of the distal compound muscle action potential (CMAP) of the median nerve [0.37 (RIQ 0.07\u20132.25) vs. 3.9 (RIQ1.2\u20136.4), <jats:italic>p<\/jats:italic> = &lt;0.001] and ulnar nerve [0.37 (RIQ0.0\u20133.72) vs 1.5 (RIQ0.3\u20136.6), <jats:italic>p<\/jats:italic> = &lt;0.001], and higher frequency of severe axonal damage in these nerves (distal CMAP \u2264 1.0 mV). Through binary logistic regression, severe axonal degeneration of the median nerve is an independent risk factor for prolonged IMV OR 4.9 (95%CI 1.1\u201321.5) <jats:italic>p<\/jats:italic> = 0.03, AUC of 0.774, (95%CI 0.66\u20130.88), <jats:italic>p<\/jats:italic> = &lt; 0.001.<\/jats:p><\/jats:sec><jats:sec id=\"S0317167123000239_as4\"><jats:title>Conclusions:<\/jats:title><jats:p>Severe median nerve damage is an independent risk factor for prolonged mechanical ventilation.<\/jats:p><\/jats:sec>","DOI":"10.1017\/cjn.2023.23","type":"journal-article","created":{"date-parts":[[2023,2,15]],"date-time":"2023-02-15T05:50:25Z","timestamp":1676440225000},"page":"98-103","source":"Crossref","is-referenced-by-count":2,"title":["Factors Predicting Prolonged Mechanical Ventilation in Guillain\u2013Barr\u00e9 Syndrome"],"prefix":"10.1017","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3419-5160","authenticated-orcid":false,"given":"Juan 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Arturo","family":"Violante-Villanueva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elma","family":"Paredes-Arag\u00f3n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2023,2,15]]},"reference":[{"key":"S0317167123000239_ref26","first-page":"1","article-title":"Predictors of mechanical ventilation in Guillain-Barr\u00e9 syndrome with axonal subtypes","volume":"22","author":"Michel-Ch\u00e1vez","year":"2022","journal-title":"Can J Neurol 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