{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T19:58:45Z","timestamp":1775678325707,"version":"3.50.1"},"reference-count":38,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2023,7,18]],"date-time":"2023-07-18T00:00:00Z","timestamp":1689638400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Neurol. Sci."],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>ABSTRACT:<\/jats:title>\n                  <jats:sec id=\"S0317167123002512_as1\">\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Levodopa-carbidopa intestinal gel (LCIG) therapy has been shown to be a safe and effective treatment for advanced Parkinson\u2019s disease (PD). Limited data are available regarding long-term benefits and complications in Canada. Objective of the study was to review long-term experience and clinical outcomes in PD patients with LCIG therapy over 11 years in a multidisciplinary University clinic setting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0317167123002512_as2\">\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Chart review was done on PD patients with LCIG from 2011 to 2022. Data collected: dosing, UPDRS-III motor scores, OFF times, hours with dyskinesias, MoCA, complications, discontinuation reasons, and nursing time requirements.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0317167123002512_as3\">\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Thirty-three patients received LCIG therapy with a mean follow-up of 3.25\u00b12.09 years. UPDRS-III scores showed reduction of 15% from baseline (mean 35.9) up to 4 years (mean 30.4). Daily OFF time improved from baseline (mean 7.1 \u00b1 3.13 hours) up to 5 years (mean 3.3 \u00b1 2.31 hours; \u221253.5%;\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.048), and dyskinesias remained stable. Nursing time averaged 22 hours per patient per year after PEG-J insertion and titration. Most common complications were PEG-J tube dislodgement and stoma site infection (0\u20133zero to three events\/patient\/year). Serious side effects were seen in four (12%) patients resulting in hospitalization and\/or death. Nine patients (27.2%) discontinued the treatment due to lack of improved efficacy over oral therapy or development of dementia and 10 (30%) died of causes unrelated to LCIG infusion.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0317167123002512_as4\">\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Patients on LCIG showed improved motor function over 5-year follow-up. Serious complications were uncommon. Dedicated nursing time is required by LCIG-trained nurses in a multidisciplinary setting for optimum management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/cjn.2023.251","type":"journal-article","created":{"date-parts":[[2023,7,18]],"date-time":"2023-07-18T05:31:32Z","timestamp":1689658292000},"page":"379-386","source":"Crossref","is-referenced-by-count":2,"title":["Levodopa-Carbidopa Intestinal Gel for Parkinson\u2019s Disease over 11 years: One Center\u2019s \u201cReal-World\u201d Experience"],"prefix":"10.1017","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0715-6193","authenticated-orcid":false,"given":"Chetan","family":"Vekhande","sequence":"first","affiliation":[{"name":"University of Alberta"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moath","family":"Hamed","sequence":"additional","affiliation":[{"name":"NYP Brooklyn, Methodist Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Genise","family":"Tremain","sequence":"additional","affiliation":[{"name":"Movement Disorders Program, Kaye Edmonton Clinic, Alberta Heath Services"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Mah","sequence":"additional","affiliation":[{"name":"Movement Disorders Program, Kaye Edmonton Clinic, Alberta Heath Services"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aakash","family":"Shetty","sequence":"additional","affiliation":[{"name":"University of Alberta"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriana","family":"Lazarescu","sequence":"additional","affiliation":[{"name":"University of Alberta"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oksana","family":"Suchowersky","sequence":"additional","affiliation":[{"name":"University of Alberta"},{"name":"Movement Disorders Program, Kaye Edmonton Clinic, Alberta Heath Services"},{"name":"University of Alberta"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2023,7,18]]},"reference":[{"key":"S0317167123002512_ref7","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(13)70293-X"},{"key":"S0317167123002512_ref9","doi-asserted-by":"publisher","DOI":"10.1097\/00002826-200305000-00010"},{"key":"S0317167123002512_ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nrl.2013.05.002"},{"key":"S0317167123002512_ref31","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-021-01747-1"},{"key":"S0317167123002512_ref38","doi-asserted-by":"publisher","DOI":"10.3233\/JPD-202104"},{"key":"S0317167123002512_ref13","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-013-7235-1"},{"key":"S0317167123002512_ref21","doi-asserted-by":"publisher","DOI":"10.2217\/nmt-2016-0021"},{"key":"S0317167123002512_ref20","doi-asserted-by":"publisher","DOI":"10.1186\/s12883-021-02269-7"},{"key":"S0317167123002512_ref34","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2012.04.010"},{"key":"S0317167123002512_ref22","first-page":"1","article-title":"Is levodopa-carbidopa intestinal gel over- or under-utilized? 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