{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T22:24:30Z","timestamp":1792275870069,"version":"4.4.0"},"reference-count":40,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2023,7,26]],"date-time":"2023-07-26T00:00:00Z","timestamp":1690329600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Neurol. Sci."],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec id=\"S0317167123002639_as1\">\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Optic nerve hypoplasia (ONH) and septo-optic-pituitary dysplasia (SOD) are common causes of congenital visual impairment. Our primary aim was to investigate the prevalence of abnormal neuroimaging features in patients with these disorders in Manitoba, Canada, and compare them with published reports.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0317167123002639_as2\">\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A retrospective neuroimaging review was performed in patients resident in Manitoba with ONH\/SOD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0317167123002639_as3\">\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      There were 128 patients (\n                      <jats:italic>M<\/jats:italic>\n                      = 70) with ONH\/SOD who had neuroimaging. Their mean age (SD) at the end of the study was 13.2 (7.5) years. Males were significantly more likely to have bilateral ONH and a small optic chiasm size, while females were more likely to have a left ONH and a small left optic chiasm size on neuroimaging (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.049). ONH and small optic chiasm size were seen in most patients on neuroimaging. Absent septum pellucidum was noted in 40%, small pituitary gland size in 28%, neuronal migration disorders (NMD) in 20% (&gt;1 type and bilateral in 13 cases), corpus callosum abnormalities were present in 9%, while olfactory bulbs-tracts and olfactory sulci were absent in 8.6% of cases. Unilateral ONH was not significantly associated with other structural brain abnormalities, while NMD were significantly associated with other midline brain abnormalities including a symmetrically small optic chiasm size.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0317167123002639_as4\">\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The prevalence of structural neuroimaging abnormalities in our cohort with ONH\/SOD was generally in the same range reported in other studies with corpus callosum abnormalities being relatively less common in our study. Bilateral NMD were relatively common among patients with NMD. The association between sex and ONH laterality requires further study.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/cjn.2023.263","type":"journal-article","created":{"date-parts":[[2023,7,26]],"date-time":"2023-07-26T03:45:23Z","timestamp":1690343123000},"page":"416-424","source":"Crossref","is-referenced-by-count":9,"title":["Neuroimaging Features in Children with Optic Nerve Hypoplasia and Septo-Optic-Pituitary Dysplasia"],"prefix":"10.1017","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0564-7044","authenticated-orcid":false,"given":"Michael S.","family":"Salman","sequence":"first","affiliation":[{"name":"Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shakhawat","family":"Hossain","sequence":"additional","affiliation":[{"name":"University of 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