{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T08:04:25Z","timestamp":1787731465614,"version":"build-2784847793"},"reference-count":15,"publisher":"Cambridge University Press (CUP)","issue":"4","license":[{"start":{"date-parts":[[2023,8,9]],"date-time":"2023-08-09T00:00:00Z","timestamp":1691539200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Neurol. Sci."],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>ABSTRACT:<\/jats:title><jats:sec id=\"S0317167123002688_as1\"><jats:title>Background:<\/jats:title><jats:p>Carpal tunnel syndrome (CTS) is one of the most common extra-cardiac manifestations of wild-type transthyretin amyloidosis (wtATTR); however, the characteristics of CTS in this population remain poorly understood.<\/jats:p><\/jats:sec><jats:sec id=\"S0317167123002688_as2\"><jats:title>Methods:<\/jats:title><jats:p>This retrospective cohort study reports findings from a single-centre experience of comprehensive neurological screening at the time of wtATTR diagnosis by nerve conduction studies (NCS) and neurologist assessment.<\/jats:p><\/jats:sec><jats:sec id=\"S0317167123002688_as3\"><jats:title>Results:<\/jats:title><jats:p>Seventy-nine patients underwent neurological screening, 73 (92%) males, mean age 79.2 \u00b1 7.5 years. Seventy-four (94%) had electrodiagnostic findings of median neuropathy at the wrist (MNW), 37 (50%) of which had a prior diagnosis of CTS and 37 (50%) had a new diagnosis of MNW. Over half of wtATTR patients (42, 53%) had bilateral MNW on screening. Most with pre-existing CTS had bilateral disease (28, 76%) and underwent bilateral carpal tunnel release (CTR) (23, 62%) prior to screening. Twenty-one (19%) wrists had mild MNW, 43 (38%) moderate\u00a0and 49 (43%) severe. Twenty-one (28%) wtATTR patients with MNW were asymptomatic, 10 of which (48%) had moderate disease. Nineteen (36%) wtATTR patients with symptomatic MNW had recurrent disease despite previous CTR. As a result of screening, 36 (68%) patients with symptomatic MNW were referred for CTR.<\/jats:p><\/jats:sec><jats:sec id=\"S0317167123002688_as4\"><jats:title>Conclusions:<\/jats:title><jats:p>MNW is exceptionally common at the time of wtATTR diagnosis, affecting 94% of our patients. Most had severe, bilateral MNW on NCS. Some were asymptomatic, despite having moderate disease. The rate of recurrence following CTR was observed to be higher in wtATTR patients than the general population.<\/jats:p><\/jats:sec>","DOI":"10.1017\/cjn.2023.268","type":"journal-article","created":{"date-parts":[[2023,8,9]],"date-time":"2023-08-09T07:57:18Z","timestamp":1691567838000},"page":"482-486","source":"Crossref","is-referenced-by-count":4,"title":["Characteristics of Carpal Tunnel Syndrome in Wild-Type Transthyretin Amyloidosis"],"prefix":"10.1017","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8837-1003","authenticated-orcid":false,"given":"Angela","family":"Russell","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahin","family":"Khayambashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nowell M.","family":"Fine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sameer","family":"Chhibber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2386-8817","authenticated-orcid":false,"given":"Christopher","family":"Hahn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2023,8,9]]},"reference":[{"key":"S0317167123002688_ref5","first-page":"e14546","article-title":"Carpal tunnel syndrome in transthyretin cardiac amyloidosis: implications and protocol for diagnosis and treatment","volume":"13","author":"Boyle","year":"2021","journal-title":"Cureus"},{"key":"S0317167123002688_ref13","doi-asserted-by":"publisher","DOI":"10.1097\/GOX.0000000000004757"},{"key":"S0317167123002688_ref8","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.116.021612"},{"key":"S0317167123002688_ref4","doi-asserted-by":"publisher","DOI":"10.3109\/13506129.2015.1135792"},{"key":"S0317167123002688_ref14","doi-asserted-by":"publisher","DOI":"10.3988\/jcn.2015.11.3.234"},{"key":"S0317167123002688_ref6","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/suab142.056"},{"key":"S0317167123002688_ref3","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.1742"},{"key":"S0317167123002688_ref10","doi-asserted-by":"publisher","DOI":"10.1002\/mus.22208"},{"key":"S0317167123002688_ref7","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.165.12.1425"},{"key":"S0317167123002688_ref9","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-07-230722"},{"key":"S0317167123002688_ref12","first-page":"1","article-title":"Utility of neuropathy screening for wild-type transthyretin amyloidosis patients","volume":"00","author":"Russell","year":"2021","journal-title":"Can J Neurol Sci"},{"key":"S0317167123002688_ref11","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1055\/s-0038-1668552","article-title":"Does the duration and severity of symptoms have an impact on relief of symptoms after carpal tunnel release?","volume":"14","author":"Musad","year":"2019","journal-title":"J Brachial Plex Peripher Nerve Inj"},{"key":"S0317167123002688_ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2019.04.003"},{"key":"S0317167123002688_ref15","doi-asserted-by":"publisher","DOI":"10.5603\/FM.a2021.0121"},{"key":"S0317167123002688_ref1","doi-asserted-by":"publisher","DOI":"10.1097\/HCO.0000000000000547"}],"container-title":["Canadian Journal of Neurological Sciences \/ Journal Canadien des Sciences Neurologiques"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0317167123002688","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T11:09:41Z","timestamp":1734347381000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0317167123002688\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,9]]},"references-count":15,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,7]]}},"alternative-id":["S0317167123002688"],"URL":"https:\/\/doi.org\/10.1017\/cjn.2023.268","relation":{},"ISSN":["0317-1671","2057-0155"],"issn-type":[{"value":"0317-1671","type":"print"},{"value":"2057-0155","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,9]]}}}