{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T07:06:51Z","timestamp":1793171211192,"version":"4.5.0"},"reference-count":24,"publisher":"Cambridge University Press (CUP)","issue":"4","license":[{"start":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T00:00:00Z","timestamp":1693267200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Neurol. Sci."],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>ABSTRACT:<\/jats:title><jats:sec id=\"S0317167123002809_as1\"><jats:title>Objective:<\/jats:title><jats:p>This study aimed to investigate the characteristics and prognosis of patients with alcoholic Marchiafava\u2013Bignami disease (MBD), a rare neurological disorder commonly associated with chronic alcoholism, in Chongqing, China.<\/jats:p><\/jats:sec><jats:sec id=\"S0317167123002809_as2\"><jats:title>Methods:<\/jats:title><jats:p>We conducted a retrospective analysis of clinical data from 21 alcoholic MBD patients treated at the First Affiliated Hospital of Chongqing University between 2012 and 2022.<\/jats:p><\/jats:sec><jats:sec id=\"S0317167123002809_as3\"><jats:title>Results:<\/jats:title><jats:p>The study included 21 patients with alcoholic MBD who had a mean age of 59 \u00b1 9.86 years and an average drinking history of 35.48 \u00b1 8.65 years. Acute onset was observed in 14 (66.7%) patients. The primary clinical signs observed were psychiatric disorders (66.7%), altered consciousness (61.9%), cognitive disorders (61.9%), and seizures (42.9%). Magnetic resonance imaging revealed long T1 and long T2 signal changes in the corpus callosum, with lesions predominantly found in the genu (76.2%) and splenium (71.4%) of the corpus callosum. The poor prognosis group demonstrated an increased incidence of altered consciousness (100% vs 50%, P = 0.044), pyramidal signs (80% vs 18.8%, P = 0.011), and pneumonia (100% vs 31.3%, P = 0.007). Patients with a longer drinking history (45.0 \u00b1 10.0 years vs 32.69 \u00b1 5.99 years, p = 0.008) and a lower thiamine dose (p = 0.035) had a poorer prognosis at 1 year.<\/jats:p><\/jats:sec><jats:sec id=\"S0317167123002809_as4\"><jats:title>Conclusions:<\/jats:title><jats:p>This study identified altered consciousness, pyramidal signs, and pneumonia as predictors of a poor prognosis in patients with alcoholic MBD. A longer duration of alcohol consumption and inadequate thiamine supplementation were associated with a poorer prognosis.<\/jats:p><\/jats:sec>","DOI":"10.1017\/cjn.2023.280","type":"journal-article","created":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T09:15:17Z","timestamp":1693300517000},"page":"513-520","source":"Crossref","is-referenced-by-count":4,"title":["Analysis of 21 Patients With Alcoholic Marchiafava\u2013Bignami Disease in Chongqing, 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