{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T20:44:25Z","timestamp":1786999465298,"version":"build-2736575974"},"reference-count":38,"publisher":"Cambridge University Press (CUP)","issue":"4","license":[{"start":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T00:00:00Z","timestamp":1697414400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Neurol. Sci."],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>ABSTRACT:<\/jats:title>\n                  <jats:sec id=\"S0317167123002998_as1\">\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Migraine poses a significant burden worldwide; however, there is limited evidence as to the burden in Canada. This study examined the treatment patterns, healthcare resource use (HRU), and costs among newly diagnosed or recurrent patients with migraine in Alberta, Canada, from the time of diagnosis or recurrence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0317167123002998_as2\">\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This retrospective observational study utilized administrative health data from Alberta, Canada. Patients were included in the Total Migraine Cohort if they had: (1) \u22651 International Classification of Diseases diagnostic code for migraine; or (2) \u22651 prescription dispense(s) for triptans from April 1, 2012, to March 31, 2018, with no previous diagnosis or dispensation code from April 1, 2010, to April 1, 2012.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0317167123002998_as3\">\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The mean age of the cohort (n = 199,931) was 40.0 years and 72.3% were women. The most common comorbidity was depression (19.7%). In each medication class examined, less than one-third of the cohort was prescribed triptans and fewer than one-fifth was prescribed a preventive. Among patients with \u22651 dispense, the mean rate of opioid prescriptions was 4.61 per patient-year, compared to 2.28 triptan prescriptions per patient-year. Migraine-related HRU accounted for 3%\u201310% of all use.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0317167123002998_as4\">\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Comorbidities and high all-cause HRU were observed among newly diagnosed or recurrent patients with migraine. There is an underutilization of acute and preventive medications in the management of migraine. The high rate of opioid use reinforces the suboptimal management of migraine in Alberta. Migraine management may improve by educating healthcare professionals to optimize treatment strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/cjn.2023.299","type":"journal-article","created":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T05:05:14Z","timestamp":1697432714000},"page":"546-556","source":"Crossref","is-referenced-by-count":4,"title":["Migraine Treatment and Healthcare Resource Utilization in Alberta, 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