{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T16:04:16Z","timestamp":1760976256089,"version":"3.40.5"},"reference-count":24,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2023,1,10]],"date-time":"2023-01-10T00:00:00Z","timestamp":1673308800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Neurol. Sci."],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>ABSTRACT:<\/jats:title><jats:sec id=\"S0317167123000033_as1\"><jats:title>Background:<\/jats:title><jats:p>In patients with intracranial steno-occlusive disease (SOD), the risk of hemodynamic stroke depends on the poststenotic vasodilatory reserve. Cerebrovascular reactivity (CVR) is a test for vasodilatory reserve. We tested for vasodilatory reserve by using P<jats:sub>ET<\/jats:sub>CO<jats:sub>2<\/jats:sub> as the stressor, and Blood Oxygen Level Dependent (BOLD) MRI as a surrogate of blood flow. We correlate the CVR to the incidence of stroke after a 1-year follow-up in patients with symptomatic intracranial SOD.<\/jats:p><\/jats:sec><jats:sec id=\"S0317167123000033_as2\"><jats:title>Methods:<\/jats:title><jats:p>In this retrospective study, 100 consecutive patients with symptomatic intracranial SOD that had undergone CVR testing were identified. CVR was measured as % BOLD MR signal intensity\/mmHg P<jats:sub>ET<\/jats:sub>CO<jats:sub>2<\/jats:sub>. All patients with normal CVR were treated with optimal medical therapy; those with abnormal CVR were offered revascularization where feasible. We determined the incidence of stroke at 1 year.<\/jats:p><\/jats:sec><jats:sec id=\"S0317167123000033_as3\"><jats:title>Results:<\/jats:title><jats:p>83 patients were included in the study. CVR was normal in 14 patients and impaired in 69 patients ipsilateral to the lesion. Of these, 53 underwent surgical revascularization. CVR and symptoms improved in 86% of the latter. The overall incidence of stroke was 4.8 % (4\/83). All strokes occurred in patients with impaired CVR (4\/69; 2\/53 in the surgical group, all in the nonrevascularized hemisphere), and none in patients with normal CVR (0\/14).<\/jats:p><\/jats:sec><jats:sec id=\"S0317167123000033_as4\"><jats:title>Conclusion:<\/jats:title><jats:p>Our study confirms that CO<jats:sub>2<\/jats:sub>-BOLD MRI CVR can be used as a brain stress test for the assessment of cerebrovascular reserve. Impaired CVR is associated with a higher incidence of stroke and normal CVR despite significant stenosis is associated with a low risk for stroke.<\/jats:p><\/jats:sec>","DOI":"10.1017\/cjn.2023.3","type":"journal-article","created":{"date-parts":[[2023,1,10]],"date-time":"2023-01-10T06:40:26Z","timestamp":1673332826000},"page":"57-63","source":"Crossref","is-referenced-by-count":3,"title":["Brain Stress Test for Assessing Risk for Hemodynamic 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