{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T04:05:08Z","timestamp":1789704308484,"version":"4.0.1"},"reference-count":24,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2023,5,8]],"date-time":"2023-05-08T00:00:00Z","timestamp":1683504000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Neurol. Sci."],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>ABSTRACT:<\/jats:title><jats:sec id=\"S0317167123000525_as1\"><jats:title>Background:<\/jats:title><jats:p>CyberKnife radiosurgery (RS), as an initial first treatment, is recognized as an efficient and safe modality for trigeminal neuralgia (TN). However, knowledge on repeat CyberKnife RS in refractory cases is limited. The objective was to evaluate the clinical outcomes of repeat CyberKnife RS for TN.<\/jats:p><\/jats:sec><jats:sec id=\"S0317167123000525_as2\"><jats:title>Methods:<\/jats:title><jats:p>A retrospective review of 33 patients with refractory TN treated a second time with CyberKnife RS from 2009 to 2021. The median follow-up period after the second RS was 26.0 months (range 0.3\u2013115.8). The median dose for the repeat RS was 60 Gy (range 60.0\u201370.0). Pain relief after the intervention was assessed using the Barrow Neurological Institute scale for pain (I\u2013V). Scores I to IIIb were classified as an adequate pain relief and scores IV\u2013V were classified as a treatment failure<\/jats:p><\/jats:sec><jats:sec id=\"S0317167123000525_as3\"><jats:title>Results:<\/jats:title><jats:p>After the second RS, initial adequate pain relief was achieved in 87.9% of cases. The actuarial probabilities of maintaining an adequate pain relief at 6, 12, 24, and 36 months were 92.1%, 74.0%, 58.2%, and 58.2%, respectively. Regarding sustained pain relief, there was no significant difference between the first and the second RS. Sensory toxicity after the first RS was predictive of a better outcome following the second RS. The onset of hypesthesia rate was the same after the first or the second RS (21%).<\/jats:p><\/jats:sec><jats:sec id=\"S0317167123000525_as4\"><jats:title>Conclusion:<\/jats:title><jats:p>Repeat RS is an effective and safe method for the treatment of refractory TN.<\/jats:p><\/jats:sec>","DOI":"10.1017\/cjn.2023.52","type":"journal-article","created":{"date-parts":[[2023,5,8]],"date-time":"2023-05-08T09:17:39Z","timestamp":1683537459000},"page":"272-277","source":"Crossref","is-referenced-by-count":2,"title":["Repeat CyberKnife Radiosurgery for Trigeminal Neuralgia: Outcomes and Complications"],"prefix":"10.1017","volume":"51","author":[{"given":"Albert","family":"Guillemette","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Roberge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sami","family":"Heymann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia","family":"M\u00e9nard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Paul","family":"Bahary","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7326-0901","authenticated-orcid":false,"given":"Marie-Pierre","family":"Fournier-Gosselin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2023,5,8]]},"reference":[{"key":"S0317167123000525_ref11","first-page":"e2598","article-title":"Evaluation of CyberKnife radiosurgery for recurrent trigeminal neuralgia","volume":"10","author":"Berti","year":"2018","journal-title":"Cureus"},{"key":"S0317167123000525_ref4","doi-asserted-by":"publisher","DOI":"10.1111\/ene.13950"},{"key":"S0317167123000525_ref15","first-page":"0","article-title":"Gamma Knife surgery for trigeminal neuralgia: a review of 450 consecutive cases: clinical article","volume":"113","author":"Verheul","year":"2010","journal-title":"J Neurosurg JNS."},{"key":"S0317167123000525_ref12","doi-asserted-by":"publisher","DOI":"10.3171\/foc.2005.18.5.4"},{"key":"S0317167123000525_ref3","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-013-1518-2"},{"key":"S0317167123000525_ref6","doi-asserted-by":"publisher","DOI":"10.3171\/2009.7.JNS09694"},{"key":"S0317167123000525_ref5","first-page":"3","article-title":"Stereotactic radiosurgery for trigeminal neuralgia: a systematic review","volume":"130","author":"Tuleasca","year":"2018","journal-title":"J Neurosurg."},{"key":"S0317167123000525_ref13","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(00)00513-7"},{"key":"S0317167123000525_ref10","first-page":"7","article-title":"Repeat Gamma Knife radiosurgery versus microvascular decompression following failure of GKRS in trigeminal neuralgia: a systematic review and meta-analysis","volume":"131","author":"Patra","year":"2018","journal-title":"J Neurosurg."},{"key":"S0317167123000525_ref18","doi-asserted-by":"publisher","DOI":"10.3171\/2015.2.JNS142144"},{"key":"S0317167123000525_ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2003.10.041"},{"key":"S0317167123000525_ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2004.03.019"},{"key":"S0317167123000525_ref23","doi-asserted-by":"publisher","DOI":"10.3171\/2010.8.GKS101075"},{"key":"S0317167123000525_ref8","first-page":"e6014","article-title":"Cyberknife Radiosurgery for Trigeminal Neuralgia","volume":"11","author":"Romanelli","year":"2019","journal-title":"Cureus."},{"key":"S0317167123000525_ref2","first-page":"1","article-title":"The International Classification of Headache Disorders","volume":"38","year":"2018","journal-title":"Cephalalgia"},{"key":"S0317167123000525_ref16","article-title":"Long-Term pain outcomes for recurrent idiopathic trigeminal neuralgia after stereotactic radiosurgery: a prospective comparison of first-time microvascular decompression and repeat stereotactic radiosurgery","author":"Raygor","journal-title":"J Neurosurg."},{"key":"S0317167123000525_ref7","doi-asserted-by":"publisher","DOI":"10.1186\/s13014-020-01535-1"},{"key":"S0317167123000525_ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2010.07.010"},{"key":"S0317167123000525_ref17","doi-asserted-by":"publisher","DOI":"10.1227\/NEU.0b013e318230218e"},{"key":"S0317167123000525_ref20","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2007.142794"},{"key":"S0317167123000525_ref9","doi-asserted-by":"publisher","DOI":"10.3171\/2014.8.GKS141487"},{"key":"S0317167123000525_ref14","doi-asserted-by":"publisher","DOI":"10.1227\/NEU.0000000000000915"},{"key":"S0317167123000525_ref1","article-title":"Neuropathic pain in the general population: a systematic review of epidemiological studies","author":"van Hecke","year":"2014","journal-title":"Pain."},{"key":"S0317167123000525_ref24","first-page":"e4777","article-title":"Immediate pain relief elicited after radiosurgery for classical and symptomatic trigeminal neuralgia","volume":"11","author":"Gorgulho","year":"2019","journal-title":"Cureus"}],"container-title":["Canadian Journal of Neurological Sciences \/ Journal Canadien des Sciences Neurologiques"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0317167123000525","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,3]],"date-time":"2024-04-03T04:39:20Z","timestamp":1712119160000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0317167123000525\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,8]]},"references-count":24,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["S0317167123000525"],"URL":"https:\/\/doi.org\/10.1017\/cjn.2023.52","relation":{},"ISSN":["0317-1671","2057-0155"],"issn-type":[{"value":"0317-1671","type":"print"},{"value":"2057-0155","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,8]]}}}