{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T07:38:20Z","timestamp":1767339500824,"version":"3.35.0"},"reference-count":18,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2024,8,19]],"date-time":"2024-08-19T00:00:00Z","timestamp":1724025600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Neurol. Sci."],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT:<\/jats:title><jats:p>Pathogenic CACNA1A mutations can result in paroxysmal attacks of encephalopathy, hemiplegia and cerebral edema. We report two patients with CACNA1A-associated encephalopathy, hemiplegia and contralateral hemispheric cerebral edema treated successfully with intravenous magnesium sulfate and dexamethasone. One patient met the clinical criteria for familial hemiplegic migraine. There is a paucity of guidance in the literature on how to manage these patients. Despite some discrepancies in the treatment protocols in our two cases, they indicate that magnesium and dexamethasone could be part of the treatment algorithm for these patients. Further research to delineate appropriate dosing and duration of therapy is needed.<\/jats:p>","DOI":"10.1017\/cjn.2024.52","type":"journal-article","created":{"date-parts":[[2024,8,19]],"date-time":"2024-08-19T09:08:55Z","timestamp":1724058535000},"page":"314-317","source":"Crossref","is-referenced-by-count":2,"title":["Treatment of CACNA1A Encephalopathy and Cerebral Edema with Magnesium and Dexamethasone"],"prefix":"10.1017","volume":"52","author":[{"given":"Cailey","family":"Turner","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lauren","family":"Campbell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryan","family":"Fung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Srirupa","family":"Desai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abimbola","family":"Oyenubi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco","family":"Cayabyab","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3772-6932","authenticated-orcid":false,"given":"Richard James","family":"Huntsman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2024,8,19]]},"reference":[{"key":"S0317167124000520_ref4","doi-asserted-by":"publisher","DOI":"10.1111\/head.13300"},{"key":"S0317167124000520_ref13","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-019-00779-4"},{"key":"S0317167124000520_ref14","doi-asserted-by":"publisher","DOI":"10.3390\/nu14051089"},{"key":"S0317167124000520_ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2012.11.012"},{"key":"S0317167124000520_ref11","doi-asserted-by":"publisher","DOI":"10.1177\/0333102416668655"},{"key":"S0317167124000520_ref15","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2020-322850"},{"key":"S0317167124000520_ref8","doi-asserted-by":"publisher","DOI":"10.1055\/s-0039-3400986"},{"key":"S0317167124000520_ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2013.04.011"},{"key":"S0317167124000520_ref10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2005.01025.x"},{"key":"S0317167124000520_ref7","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-018-0616-5"},{"key":"S0317167124000520_ref5","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200421227"},{"key":"S0317167124000520_ref9","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2009.177279"},{"key":"S0317167124000520_ref3","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-010-0802-8"},{"year":"2001","author":"Jen","key":"S0317167124000520_ref2"},{"key":"S0317167124000520_ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.jemermed.2013.08.049"},{"key":"S0317167124000520_ref16","doi-asserted-by":"publisher","DOI":"10.3390\/nu12092660"},{"volume-title":"Magnesium Sulfate: Appendix E: Magnesium Sulfate for Refractory Migraine in ED","year":"2016","author":"Allen","key":"S0317167124000520_ref18"},{"key":"S0317167124000520_ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2019.10.003"}],"container-title":["Canadian Journal of Neurological Sciences \/ Journal Canadien des Sciences Neurologiques"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0317167124000520","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,3]],"date-time":"2025-02-03T06:16:02Z","timestamp":1738563362000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0317167124000520\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,19]]},"references-count":18,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["S0317167124000520"],"URL":"https:\/\/doi.org\/10.1017\/cjn.2024.52","relation":{},"ISSN":["0317-1671","2057-0155"],"issn-type":[{"type":"print","value":"0317-1671"},{"type":"electronic","value":"2057-0155"}],"subject":[],"published":{"date-parts":[[2024,8,19]]}}}