{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T15:41:12Z","timestamp":1772811672690,"version":"3.50.1"},"reference-count":30,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T00:00:00Z","timestamp":1748217600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Neurol. Sci."],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec id=\"S0317167125100929_as1\">\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Huntington\u2019s disease (HD) is an inherited, neurodegenerative disorder caused by the expansion of an unstable CAG repeat sequence in the Huntingtin (HTT) gene. The prevalence of HD, allelic diversity, rate of novel expansions and the clinical correlates vary across populations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0317167125100929_as2\">\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>We analyzed the diversity of alleles and their clinical correlates and examined the inheritance patterns and the pattern of instability of CAG repeats in a few families.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0317167125100929_as3\">\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Clinical history and pedigree structure were collected from records or through interviews between 2016 and 2019. Genetic testing at the HD locus was done on clinical suspicion, or relatedness, after counseling. Descriptive statistics and correlation analysis were used.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0317167125100929_as4\">\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Expanded repeats were detected in 239 individuals, including 232 who were symptomatic and 7 presymptomatic relatives. The number of CAG repeats (mean = 45.6) and age at onset (mean = 39.2 years) showed a strong inverse correlation (\n                      <jats:italic>r<\/jats:italic>\n                      = -0.67). We found atypical alleles such as 8 intermediate alleles (IA), 12 reduced penetrance alleles and 14 large (&gt;60) expansion alleles corresponding to juvenile HD. Three individuals carried biallelic expansions. Paternal inheritance was more common, and the mean increase in repeats in the available parent-child pairs was 14. Thirty-seven individuals had no family history of HD, with\n                      <jats:italic>de novo<\/jats:italic>\n                      expansion confirmed in three cases.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0317167125100929_as5\">\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>\n                      Novel mutations at the HTT locus may not be rare in India. A lack of family history should not exclude appropriate testing. The prevalence of IA and incidence of\n                      <jats:italic>de novo<\/jats:italic>\n                      expansions suggest that there may be a reservoir of alleles prone to expansion.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/cjn.2025.10092","type":"journal-article","created":{"date-parts":[[2025,6,23]],"date-time":"2025-06-23T04:34:19Z","timestamp":1750653259000},"page":"202-208","source":"Crossref","is-referenced-by-count":2,"title":["Allelic Diversity, De Novo CAG Expansions and Intergenerational Instability at the HTT Locus in a Sample from India"],"prefix":"10.1017","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0094-1236","authenticated-orcid":false,"given":"Nikhil","family":"Ratna","sequence":"first","affiliation":[{"name":"National Institute of Mental Health and Neurosciences"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sowmya","family":"Devatha Venkatesh","sequence":"additional","affiliation":[{"name":"National Institute of Mental Health and Neurosciences"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Swathi","family":"Pasupulati","sequence":"additional","affiliation":[{"name":"National Institute of Mental Health and Neurosciences"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geetanjali","family":"Murari","sequence":"additional","affiliation":[{"name":"National Institute of Mental Health and Neurosciences"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nitish","family":"Kamble","sequence":"additional","affiliation":[{"name":"National Institute of Mental Health and Neurosciences"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Biju","family":"Viswanath","sequence":"additional","affiliation":[{"name":"National Institute of Mental Health and 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