{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T09:10:26Z","timestamp":1792228226638,"version":"4.4.0"},"reference-count":25,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2025,6,27]],"date-time":"2025-06-27T00:00:00Z","timestamp":1750982400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Neurol. Sci."],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec id=\"S031716712510125X_as1\">\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Historically, it has been proposed that functional neurological symptoms occur more frequently on the left side of the body due to a distinct body representation and emotional processing of the right hemisphere, yet objective imaging data to support this are lacking. We aimed to investigate whether patients with acute left-sided symptoms (right hemisphere) suspected of having a minor stroke are more likely to show negative diffusion-weighted imaging (DWI) compared to those with right-sided symptoms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S031716712510125X_as2\">\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Data are from the SpecTRA (Spectrometry for Transient Ischemic Attack Rapid Assessment) multicenter prospective cohort study conducted between 2013 and 2017. Patients with mild persistent unilateral hemiparesis and\/or hemisensory symptoms (National Institute of Health Stroke Scale \u2264 3) and available DWI were included. The primary outcome was the proportion of patients with a negative DWI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S031716712510125X_as3\">\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Of 1731 patients, 584 (30.8%) were included. Of these, 310 (53.1%) patients presented with left-sided symptoms and 274 (46.9%) with right-sided symptoms. Overall, 214 (36.6%) patients had a negative DWI, 126 (58.9%) with left-sided symptoms and 88 (41.1%) with right-sided symptoms: risk ratio (RR) 1.27 (95% CI = 1.02\u20131.57). Left-sided hemiparesis was associated with negative DWI (RR 1.42 [95% CI = 1.08\u20131.87]), while left-sided hemisensory symptoms were not (RR 1.11 [95% CI = 0.87\u20131.41]). There was no effect modification by age or sex on this association (P\n                      <jats:sub>interaction<\/jats:sub>\n                      0.787 and 0.057, respectively).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S031716712510125X_as4\">\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Unilateral left-sided neurological symptoms were more frequently associated with negative DWI compared to right-sided symptoms in suspected minor stroke patients. This observation is exploratory, as the final diagnosis in DWI-negative cases was not established.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/cjn.2025.10125","type":"journal-article","created":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T06:50:34Z","timestamp":1747637434000},"page":"386-391","source":"Crossref","is-referenced-by-count":3,"title":["Left-Sided Neurological Symptoms and Negative Diffusion-Weighted MRI in Suspected Minor Stroke Patients"],"prefix":"10.1017","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4042-4735","authenticated-orcid":false,"given":"Umberto","family":"Pensato","sequence":"first","affiliation":[{"name":"IRCCS Humanitas Research Hospital"},{"name":"Humanitas University"},{"name":"University of Calgary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nishita","family":"Singh","sequence":"additional","affiliation":[{"name":"University of Manitoba"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9554-0701","authenticated-orcid":false,"given":"Raed A.","family":"Joundi","sequence":"additional","affiliation":[{"name":"McMaster University & Population Health Research Institute"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Tanaka","sequence":"additional","affiliation":[{"name":"University of Calgary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew M. 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