{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T12:49:19Z","timestamp":1773406159531,"version":"3.50.1"},"reference-count":36,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2025,3,3]],"date-time":"2025-03-03T00:00:00Z","timestamp":1740960000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Neurol. Sci."],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec id=\"S031716712500037X_as1\">\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>The outcomes of radiosurgery for trigeminal neuralgia (TN) in patients with multiple sclerosis (MS) are not as extensively assessed as those for idiopathic or classical TN cases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S031716712500037X_as2\">\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>Evaluate the safety and efficacy of radiosurgery for TN in MS patients and identify potential predictors of successful outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S031716712500037X_as3\">\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A retrospective single-institution cohort study with patients treated between 2009 and 2022 was performed. Fifty patients were included, and a total of 68 radiosurgical interventions were delivered. Outcomes included the maintenance of pain relief assessed using Kaplan\u2013Meier curves and treatment-related complications. Cox regression analyses were used to identify potential predictors of better pain relief.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S031716712500037X_as4\">\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Following the first radiosurgical treatments, the initial pain relief rate was 86% after a median latency period of 14 days. Adequate pain relief rates at 6, 12, 36 and 60 months were 86%, 52%, 35% and 24%, respectively. Adequate pain relief was sustained for an actuarial median of 12.7 months. After initial relief, pain recurrence occurred in 68% of patients. No statistical difference was seen in the duration of pain relief after initial or repeat radiosurgery (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.368). The most frequent complication was facial hypesthesia (Barrow Neurological Institute facial hypesthesia scale grade II: 10%; III: 6%; IV: 0%). Ipsilateral vascular compression was predictive of better efficacy (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.024).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S031716712500037X_as5\">\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Radiosurgery for TN in patients with MS appears to be safe and to provide effective pain relief. Notably, radiological identification of vascular compression may predict more sustained pain relief.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/cjn.2025.37","type":"journal-article","created":{"date-parts":[[2025,3,3]],"date-time":"2025-03-03T04:10:19Z","timestamp":1740975019000},"page":"62-68","source":"Crossref","is-referenced-by-count":3,"title":["Outcomes of CyberKnife Radiosurgery for Trigeminal Neuralgia in Patients with Multiple Sclerosis"],"prefix":"10.1017","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7149-5202","authenticated-orcid":false,"given":"Albert","family":"Guillemette","sequence":"first","affiliation":[{"name":"Centre de Recherche du Centre hospitalier de l\u2019Universit\u00e9 de Montr\u00e9al (CRCHUM)"},{"name":"Universit\u00e9 de Montr\u00e9al"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Roberge","sequence":"additional","affiliation":[{"name":"Centre de Recherche du Centre hospitalier de 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