{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T15:15:21Z","timestamp":1789139721082,"version":"build-2803163510"},"reference-count":35,"publisher":"Cambridge University Press (CUP)","issue":"5","license":[{"start":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T00:00:00Z","timestamp":1744329600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Neurol. Sci."],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec id=\"S0317167125000496_as1\">\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Individuals undergoing cranioplasty may encounter persistent functional impairments. Quality-of-life (QoL) assessment to address this is essential. This study aims to evaluate the long-term improvement in QoL after a cranioplasty at our center.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0317167125000496_as2\">\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>In this observational, retrospective study, we assessed the QoL of patients who underwent cranioplasty and could be contacted by our research team. QoL was evaluated using EuroQol-5D-3L and SF-36 scales through phone interviews. We evaluated QoL changes at 3, 6 and 12 months. Friedman\u2019s test and repeated measures ANOVA were used to assess QoL improvement through time. An exploratory analysis to search for possible modifiers of QoL improvement was conducted.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0317167125000496_as3\">\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      We included 28 patients with a median age of 30 (IQR 20\u221252) years, of whom 19 (79.2%) had a history of trauma. Twenty (71.4%) patients underwent cranioplasty with custom-made 3D-modeled implants. Long-term improvements in general QoL were observed in mobility, self-care, usual activities and pain\/discomfort (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001). Improvement in SF-36 scores showed significant mean differences in role limitations due to physical health (\u221232.14, 95% CI \u221250.37 to \u221213.91;\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001), role limitations due to emotional problems (\u221221.43, 95% CI \u221238.5 to \u22124.35;\n                      <jats:italic>p<\/jats:italic>\n                      = 0.010) and pain (\u22129.65, 95% CI \u221216.36 to \u22122.93;\n                      <jats:italic>p<\/jats:italic>\n                      = 0.003). There were no significant modifiers of QoL improvement.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0317167125000496_as4\">\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>This study showed promising results about QoL improvement experienced by patients with low-cost customized implants. Further research is necessary to preserve clinical and self-reported improvement and conduct patient-centered neurosurgical care.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/cjn.2025.49","type":"journal-article","created":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T03:44:33Z","timestamp":1744343073000},"page":"730-738","source":"Crossref","is-referenced-by-count":0,"title":["The Impact of Low-Cost Customized Cranioplasty Implants in a Low-Income Population: Does Quality of Life Improve?"],"prefix":"10.1017","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4959-8237","authenticated-orcid":false,"given":"Jorge Alberto","family":"Cant\u00fa-Hern\u00e1ndez","sequence":"first","affiliation":[{"name":"Hospital Universitario \u201cDr. Jos\u00e9 Eleuterio Gonz\u00e1lez\u201d"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cesar Alessandro","family":"Ramos-Delgado","sequence":"additional","affiliation":[{"name":"Hospital Universitario 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