{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T02:38:29Z","timestamp":1789180709111,"version":"build-2803163510"},"reference-count":47,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T00:00:00Z","timestamp":1744243200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Neurol. Sci."],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec id=\"S0317167125000642_as1\">\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Since cannabis was legalized in Canada in 2018, its use among older adults has increased. Although cannabis may exacerbate cognitive impairment, there are few studies on its use among older adults being evaluated for cognitive disorders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0317167125000642_as2\">\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We analyzed data from 238 patients who attended a cognitive clinic between 2019 and 2023 and provided data on cannabis use. Health professionals collected information using a standardized case report form.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0317167125000642_as3\">\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Cannabis use was reported by 23 out of 238 patients (9.7%): 12 took cannabis for recreation, 8 for medicinal purposes and 3 for both purposes. Compared to non-users, cannabis users were younger (mean \u00b1 SD 62.0 \u00b1 7.5 vs 68.9 \u00b1 9.5 years;\n                      <jats:italic>p<\/jats:italic>\n                      = 0.001), more likely to have a mood disorder (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.05) and be current or former cigarette smokers (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.05). There were no significant differences in sex, race or education. The proportion with dementia compared with pre-dementia cognitive states did not differ significantly in users compared with non-users. Cognitive test scores were similar in users compared with non-users (Montreal Cognitive Assessment: 20.4 \u00b1 5.0 vs 20.7 \u00b1 4.5,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.81; Folstein Mini-Mental Status Exam: 24.5 \u00b1 5.1 vs 26.0 \u00b1 3.6,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.25). The prevalence of insomnia, obstructive sleep apnea, anxiety disorders, alcohol use or psychotic disorders did not differ significantly.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0317167125000642_as4\">\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The prevalence of cannabis use among patients with cognitive concerns in this study was similar to the general Canadian population aged 65 and older. Further research is necessary to investigate patients\u2019 motivations for use and explore the relationship between cannabis use and mood disorders and cognitive decline.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/cjn.2025.64","type":"journal-article","created":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T05:38:37Z","timestamp":1744263517000},"page":"176-182","source":"Crossref","is-referenced-by-count":1,"title":["Cannabis Use Prevalence and Correlates in Patients Attending a Canadian Cognitive Clinic"],"prefix":"10.1017","volume":"53","author":[{"given":"Yvette Y.","family":"Yao","sequence":"first","affiliation":[{"name":"University of Calgary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colleen J.","family":"Maxwell","sequence":"additional","affiliation":[{"name":"Waterloo University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahinoor","family":"Ismail","sequence":"additional","affiliation":[{"name":"University of Calgary"},{"name":"University of Calgary"},{"name":"Cumming School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly G.","family":"Williams","sequence":"additional","affiliation":[{"name":"University of Calgary"},{"name":"Cumming School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karyn","family":"Fischer","sequence":"additional","affiliation":[{"name":"University of Calgary"},{"name":"Cumming School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David B.","family":"Hogan","sequence":"additional","affiliation":[{"name":"University of Calgary"},{"name":"University of Calgary"},{"name":"Cumming School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dallas P.","family":"Seitz","sequence":"additional","affiliation":[{"name":"University of Calgary"},{"name":"University of Calgary"},{"name":"Cumming School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3956-1668","authenticated-orcid":false,"given":"Eric E.","family":"Smith","sequence":"additional","affiliation":[{"name":"University of Calgary"},{"name":"University of Calgary"},{"name":"Cumming School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2025,4,10]]},"reference":[{"key":"S0317167125000642_ref9","doi-asserted-by":"publisher","DOI":"10.1080\/07317115.2020.1746720"},{"key":"S0317167125000642_ref33","doi-asserted-by":"publisher","DOI":"10.1093\/ntr\/ntz085"},{"key":"S0317167125000642_ref45","doi-asserted-by":"publisher","DOI":"10.1186\/s12954-023-00753-6"},{"key":"S0317167125000642_ref28","doi-asserted-by":"publisher","DOI":"10.7326\/M20-0863"},{"key":"S0317167125000642_ref34","doi-asserted-by":"publisher","DOI":"10.1159\/000239685"},{"key":"S0317167125000642_ref15","doi-asserted-by":"publisher","DOI":"10.1007\/s40266-021-00913-y"},{"key":"S0317167125000642_ref11","doi-asserted-by":"publisher","DOI":"10.1097\/JCP.0b013e31820e861c"},{"key":"S0317167125000642_ref31","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugpo.2015.03.008"},{"key":"S0317167125000642_ref19","first-page":"37","article-title":"Cannabinoids for treatment of Alzheimer\u2019s disease: moving toward the clinic","volume":"5","author":"Ferrer","year":"2014","journal-title":"Front Pharmacol"},{"key":"S0317167125000642_ref40","unstructured":"40. Peprah, K , McCormack, S. Medical Cannabis for the Treatment of Dementia: A Review of Clinical Effectiveness and Guidelines. Canadian Agency for Drugs and Technologies in Health; 2019. 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Chambers, LW , Bancej, C , McDowell, I. Prevalence and monetary costs of dementia in Canada. Alzheimer Society of Canada. 2016. https:\/\/www.alzheimer.ca\/sites\/default\/files\/documents\/prevalenceandcostsofdementia_en_0.pdf."},{"key":"S0317167125000642_ref18","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-130137"},{"key":"S0317167125000642_ref7","doi-asserted-by":"publisher","DOI":"10.1177\/2333721418781668"},{"key":"S0317167125000642_ref25","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2014.01.001"},{"key":"S0317167125000642_ref37","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2024.1346207"},{"key":"S0317167125000642_ref20","doi-asserted-by":"publisher","DOI":"10.1080\/07317115.2020.1852465"},{"key":"S0317167125000642_ref35","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1176\/ajp.142.11.1259","article-title":"The self-medication hypothesis of addictive disorders: focus on heroin and cocaine dependence","volume":"142","author":"Khantzian","year":"1985","journal-title":"Am J Psychiatry"},{"key":"S0317167125000642_ref41","first-page":"607","article-title":"Review of the endocannabinoid system","volume":"6","author":"Lu","year":"2021","journal-title":"Biol Psychiatry Cogn Neurosci Neuroimaging"},{"key":"S0317167125000642_ref42","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12105"},{"key":"S0317167125000642_ref10","doi-asserted-by":"publisher","DOI":"10.1093\/geront\/gnz054"},{"key":"S0317167125000642_ref3","unstructured":"3. 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