{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T11:10:06Z","timestamp":1785409806634,"version":"3.56.0"},"reference-count":12,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T00:00:00Z","timestamp":1770249600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Neurol. Sci."],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Neuroinflammatory syndromes in children often present with overlapping clinical, radiological and immunological features, posing significant diagnostic challenges. We describe two pediatric patients with acute neuroinflammatory presentations who fulfilled criteria for a well-recognized antibody-associated demyelinating disorder but also demonstrated clinical and laboratory features suggestive of a broader hyperinflammatory process. These cases underscore the diagnostic complexity when systemic and central nervous system inflammation coexist and highlight the importance of maintaining a broad differential diagnosis. Clinicians should be aware that antibody positivity does not preclude alternative or coexisting diagnoses and that failure to recognize hyperinflammatory syndromes may delay appropriate therapy.<\/jats:p>","DOI":"10.1017\/cjn.2026.10556","type":"journal-article","created":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T07:24:15Z","timestamp":1770276255000},"page":"1-5","source":"Crossref","is-referenced-by-count":0,"title":["Thinking Outside of the MOGAD Box: When Does CNS-Hemophagocytic Lymphohistiocytosis Make More Sense?"],"prefix":"10.1017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4180-1915","authenticated-orcid":false,"given":"Lama","family":"Aljomah","sequence":"first","affiliation":[{"name":"The Hospital for Sick Children"},{"id":[{"id":"https:\/\/ror.org\/03dbr7087","id-type":"ROR","asserted-by":"publisher"}],"name":"The Hospital for Sick Children, Faculty of Medicine, the University of Toronto"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rabporn","family":"Suntornlohanakul","sequence":"additional","affiliation":[{"name":"The Hospital for Sick Children"},{"id":[{"id":"https:\/\/ror.org\/03dbr7087","id-type":"ROR","asserted-by":"publisher"}],"name":"The Hospital for Sick Children, Faculty of Medicine, the University of Toronto"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Areej","family":"Mahjoub","sequence":"additional","affiliation":[{"name":"The Hospital for Sick Children"},{"id":[{"id":"https:\/\/ror.org\/03dbr7087","id-type":"ROR","asserted-by":"publisher"}],"name":"The Hospital for Sick Children, Faculty of Medicine, the University of Toronto"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"Branson","sequence":"additional","affiliation":[{"name":"The Hospital for Sick Children"},{"name":"The Hospital for Sick Children, Faculty of Medical Imaging, University of Toronto"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9645-5856","authenticated-orcid":false,"given":"Ahmed","family":"Naqvi","sequence":"additional","affiliation":[{"name":"The Hospital for Sick Children"},{"name":"The Hospital for Sick Children, Faculty of Medicine, the University of Toronto"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. 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