{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T11:38:18Z","timestamp":1785411498202,"version":"3.56.0"},"reference-count":31,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T00:00:00Z","timestamp":1770163200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Neurol. Sci."],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec id=\"S0317167126105575_as1\">\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Early detection of respiratory decline is crucial in amyotrophic lateral sclerosis (ALS). We tested if nocturnal polysomnography (PSG) predicts dyspnea onset in mild ALS patients with preserved daytime function.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0317167126105575_as2\">\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      In this study, 41 mild ALS patients (ALS Functional Rating Scale-Revised [ALSFRS-R] \u2265 37, sitting forced vital capacity [FVC] \u226580% predicted, no dyspnea) and 41 matched controls underwent baseline assessment, including ALSFRS-R scoring, pulmonary function tests, and overnight PSG. ALS patients were followed for 12 months. Baseline apnea\u2013hypopnea index (AHI) and oxygen saturation (mean SpO\n                      <jats:sub>2<\/jats:sub>\n                      , minimum SpO\n                      <jats:sub>2<\/jats:sub>\n                      ) were analyzed as continuous predictors and using exploratory thresholds (AHI \u2265 5 events\/h, min SpO\n                      <jats:sub>2<\/jats:sub>\n                      \u2264 88%, mean SpO\n                      <jats:sub>2<\/jats:sub>\n                      \u2264 95%) for dyspnea onset (Dyspnea-ALS-15 [DALS-15] &gt; 0).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0317167126105575_as3\">\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Compared to controls, ALS patients had significantly higher AHI (p = 0.004) and lower minimum SpO\n                      <jats:sub>2<\/jats:sub>\n                      (p = 0.018). The ALSFRS-R orthopnea subscore showed a significant positive correlation with mean and minimum SpO\n                      <jats:sub>2<\/jats:sub>\n                      (P &lt; 0.05). Cox regression identified baseline AHI (HR 1.08 per event\/h; 95% CI 1.01\u20131.15, p = 0.028) and minimum SpO\n                      <jats:sub>2<\/jats:sub>\n                      (HR 0.94 per %; 95% CI 0.88\u20130.99, p = 0.033) as independent predictors of dyspnea onset within 12 months. Thresholds AHI \u2265 5 (HR 2.28, p = 0.031) and min SpO\n                      <jats:sub>2<\/jats:sub>\n                      \u2264 88% (HR 2.42, p = 0.027) also predicted increased risk. Patients meeting \u22651 threshold (n = 25\/37) showed trends toward greater FVC and ALSFRS-R decline.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0317167126105575_as4\">\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>\n                      In patients with mild ALS and normal daytime function, specific nocturnal PSG parameters (AHI, minimum SpO\n                      <jats:sub>2<\/jats:sub>\n                      ) predicted the risk of dyspnea within 12 months. This longitudinal study provides novel evidence that PSG could identify early respiratory vulnerability in the incipient stage, earlier than conventional FVC-based monitoring, supporting its potential utility in refining early intervention strategies. Validation in larger cohorts is warranted.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/cjn.2026.10557","type":"journal-article","created":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T08:41:41Z","timestamp":1770194501000},"page":"1-6","source":"Crossref","is-referenced-by-count":1,"title":["Nocturnal Hypoxia and Sleep-Disordered Breathing as Potential Early Biomarkers of Respiratory Progression in Mild ALS"],"prefix":"10.1017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6789-2013","authenticated-orcid":false,"given":"Xueming","family":"Li","sequence":"first","affiliation":[{"name":"Nanchang University Second Affiliated Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weijiang","family":"Ding","sequence":"additional","affiliation":[{"name":"Nanchang University Second Affiliated Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Lu","sequence":"additional","affiliation":[{"name":"Xingguo County People\u2019s Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meiying","family":"Sun","sequence":"additional","affiliation":[{"name":"Gaoxin branch of the First Affiliated Hospital of Nanchang University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enwang","family":"Xu","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00g3pqv36","id-type":"ROR","asserted-by":"publisher"}],"name":"The First Affiliated Hospital of Jiangxi Medical College"},{"name":"The Central Hospital of Shangrao"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2026,2,4]]},"reference":[{"key":"S0317167126105575_ref12","doi-asserted-by":"publisher","DOI":"10.1080\/146608200300079536"},{"key":"S0317167126105575_ref24","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2025.105845"},{"key":"S0317167126105575_ref23","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2023.1193483"},{"key":"S0317167126105575_ref27","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.191721"},{"key":"S0317167126105575_ref31","doi-asserted-by":"publisher","DOI":"10.3389\/fresc.2023.1152043"},{"key":"S0317167126105575_ref14","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-021-10563-0"},{"key":"S0317167126105575_ref4","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-024-12523-w"},{"key":"S0317167126105575_ref17","doi-asserted-by":"publisher","DOI":"10.1183\/20734735.0266-2022"},{"key":"S0317167126105575_ref8","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00261-2019"},{"key":"S0317167126105575_ref21","doi-asserted-by":"publisher","DOI":"10.1111\/cns.70384"},{"key":"S0317167126105575_ref22","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci14100978"},{"key":"S0317167126105575_ref19","doi-asserted-by":"publisher","DOI":"10.1007\/s11325-015-1247-2"},{"key":"S0317167126105575_ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e32250"},{"key":"S0317167126105575_ref3","doi-asserted-by":"publisher","DOI":"10.3390\/jcm14196702"},{"key":"S0317167126105575_ref10","doi-asserted-by":"publisher","DOI":"10.3109\/21678421.2016.1170149"},{"key":"S0317167126105575_ref28","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000003158"},{"key":"S0317167126105575_ref20","doi-asserted-by":"publisher","DOI":"10.1183\/16000617.0162-2024"},{"key":"S0317167126105575_ref18","first-page":"e78903","article-title":"Analysis of respiratory muscle strength training in amyotrophic lateral sclerosis (ALS) patients: A systematic review","volume":"17","author":"Ansari","year":"2025","journal-title":"Cureus"},{"key":"S0317167126105575_ref1","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2025.1608853"},{"key":"S0317167126105575_ref25","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2024.1430875"},{"key":"S0317167126105575_ref16","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2024.1357070"},{"key":"S0317167126105575_ref2","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics11020231"},{"key":"S0317167126105575_ref30","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics15070884"},{"key":"S0317167126105575_ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2023.04.014"},{"key":"S0317167126105575_ref15","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1055\/a-2349-0936","article-title":"Prediction of nocturnal ventilation by pulmonary function testing in patients with amyotrophic lateral sclerosis. Pr\u00e4diktion der n\u00e4chtlichen ventilation durch Lungenfunktionsuntersuchungen bei Patienten mit amyotropher lateralsklerose","volume":"78","author":"Tress","year":"2024","journal-title":"Pneumologie"},{"key":"S0317167126105575_ref13","first-page":"e85348","article-title":"Motor unit number estimation for evaluating disease progression and comparison with functional rating scale scores in patients with amyotrophic lateral sclerosis","volume":"17","author":"Rani","year":"2025","journal-title":"Cureus"},{"key":"S0317167126105575_ref6","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2025.1588992"},{"key":"S0317167126105575_ref11","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-020-01047-1"},{"key":"S0317167126105575_ref29","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2012.07.045"},{"key":"S0317167126105575_ref5","doi-asserted-by":"publisher","DOI":"10.1177\/17534666251346095"},{"key":"S0317167126105575_ref26","doi-asserted-by":"publisher","DOI":"10.1038\/s41594-020-00537-7"}],"container-title":["Canadian Journal of Neurological Sciences \/ Journal Canadien des Sciences Neurologiques"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0317167126105575","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T06:53:01Z","timestamp":1784271181000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0317167126105575\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,4]]},"references-count":31,"alternative-id":["S0317167126105575"],"URL":"https:\/\/doi.org\/10.1017\/cjn.2026.10557","relation":{},"ISSN":["0317-1671","2057-0155"],"issn-type":[{"value":"0317-1671","type":"print"},{"value":"2057-0155","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,4]]}}}