{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T01:05:43Z","timestamp":1793754343431,"version":"4.6.1"},"reference-count":10,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T00:00:00Z","timestamp":1778112000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Neurol. Sci."],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Smoking nicotine-related substances influences depressive symptoms in people with relapsing-remitting multiple sclerosis (pwRRMS). It remains unknown whether sex impacts this relationship. Addressing this gap, in a consecutive sample of 281 pwRRMS, the mean age was 42.0 years (SD = 11.0), 74.7% were female, 19.9% smoked nicotine-related substances and the mean Hospital Anxiety and Depression Scale depression sub-scale (HADS-D) score was 7.0 (SD = 4.0). Controlling for covariates, sex and smoked nicotine use interacted to influence HADS-D scores (\n                    <jats:italic>p<\/jats:italic>\n                    = 0.015). In females alone, smoked nicotine use predicted increased HADS-D scores (\n                    <jats:italic>p<\/jats:italic>\n                    = 0.002). The link between smoked nicotine use and depressive symptoms differs between males and females with relapsing-remitting multiple sclerosis.\n                  <\/jats:p>","DOI":"10.1017\/cjn.2026.10617","type":"journal-article","created":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T08:52:39Z","timestamp":1778143959000},"page":"1-3","source":"Crossref","is-referenced-by-count":1,"title":["Smoked Nicotine Use Is Associated with Depressive Symptoms in Women with Multiple Sclerosis"],"prefix":"10.1017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4340-3232","authenticated-orcid":false,"given":"David Eli","family":"Freedman","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03wefcv03","id-type":"ROR","asserted-by":"publisher"}],"name":"Sunnybrook Health Sciences Centre"},{"id":[{"id":"https:\/\/ror.org\/03dbr7087","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Toronto"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiwon","family":"Oh","sequence":"additional","affiliation":[{"name":"St Michael\u2019s Hospital"},{"name":"University of Toronto"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"David","sequence":"additional","affiliation":[{"name":"York University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0132-0909","authenticated-orcid":false,"given":"Anthony","family":"Feinstein","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03wefcv03","id-type":"ROR","asserted-by":"publisher"}],"name":"Sunnybrook Health Sciences Centre"},{"id":[{"id":"https:\/\/ror.org\/03dbr7087","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Toronto"},{"name":"St Michael\u2019s Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2026,5,7]]},"reference":[{"key":"S0317167126106179_ref4","doi-asserted-by":"publisher","DOI":"10.3109\/00952990.2016.1171327"},{"key":"S0317167126106179_ref2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2019.4271"},{"key":"S0317167126106179_ref7","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.33.11.1444"},{"key":"S0317167126106179_ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2023.104501"},{"key":"S0317167126106179_ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2019.01.045"},{"key":"S0317167126106179_ref1","first-page":"4210","article-title":"Is multiple sclerosis-related depression different from depression in general? The data for and against","volume":"148","author":"Feinstein","year":"2025","journal-title":"Brain"},{"key":"S0317167126106179_ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2021.11.013"},{"key":"S0317167126106179_ref9","doi-asserted-by":"publisher","DOI":"10.1177\/1352458509347150"},{"key":"S0317167126106179_ref10","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2022-330848"},{"key":"S0317167126106179_ref8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1983.tb09716.x"}],"container-title":["Canadian Journal of Neurological Sciences \/ Journal Canadien des Sciences Neurologiques"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0317167126106179","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T07:11:05Z","timestamp":1784272265000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0317167126106179\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,7]]},"references-count":10,"alternative-id":["S0317167126106179"],"URL":"https:\/\/doi.org\/10.1017\/cjn.2026.10617","relation":{},"ISSN":["0317-1671","2057-0155"],"issn-type":[{"value":"0317-1671","type":"print"},{"value":"2057-0155","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,7]]}}}