{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T07:47:24Z","timestamp":1791964044667,"version":"4.3.4"},"reference-count":21,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:00:00Z","timestamp":1791936000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Neurol. Sci."],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec id=\"S0317167126106763_as1\">\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Telestroke allows rapid assessment of acute stroke patients for intravenous thrombolysis and endovascular thrombectomy (EVT). While its safety and efficacy for thrombolysis are well established, evidence regarding EVT decision-making via telestroke is scarce.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0317167126106763_as2\">\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We analysed data from Optimising Patient Treatment In Major Ischaemic Stroke with EVT (OPTIMISE), an EVT registry of Canadian comprehensive stroke centres. We compared unadjusted time metrics and procedural outcomes between patients treated with EVT evaluated via telestroke and those evaluated without telestroke. A primary analysis included all EVT cases, and a sub-analysis focused on patients transferred from another centre. Mixed-effects logistic regression, adjusted for relevant clinical and radiological confounders, was used to assess symptomatic intracerebral haemorrhage (sICH), good functional outcome and all-cause mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0317167126106763_as3\">\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Between 2018 and 2021, a total of 6803 patients received EVT across 20 centres. Patients receiving telestroke consultation had longer onset-to-EVT centre door time and onset-to-groin puncture time. In unadjusted analyses, telestroke patients had higher sICH proportions (6.5% vs. 3.1%), lower proportions of good functional outcomes (35.6% vs. 40.6%) and higher all-cause mortality (39.9% vs. 27.5%) compared to those not receiving telestroke consultation. These differences did not persist in adjusted analyses. The sub-analysis with multivariate adjustment restricted to transferred patients also revealed no differences in outcomes between the two groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0317167126106763_as4\">\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Patients evaluated with telestroke prior to EVT had longer treatment times than those not evaluated with telestroke. The higher risk for unfavourable outcomes did not persist after adjustment for confounders. There remains a strong need to optimise the delivery of EVT for patients evaluated at telestroke centres.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/cjn.2026.10676","type":"journal-article","created":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T07:14:33Z","timestamp":1791962073000},"page":"1-7","source":"Crossref","is-referenced-by-count":0,"title":["Use of Telestroke Prior to Endovascular Stroke Treatment in Canada: Results from the OPTIMISE Registry"],"prefix":"10.1017","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-9783-5321","authenticated-orcid":false,"given":"Justin","family":"Barrette","sequence":"first","affiliation":[{"name":"Universit\u00e9 de Montr\u00e9al"},{"name":"Centre Hospitalier de L\u2019Universite de Montreal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed A.","family":"Tarek","sequence":"additional","affiliation":[{"name":"McMaster University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4362-1571","authenticated-orcid":false,"given":"Gregory","family":"Jacquin","sequence":"additional","affiliation":[{"name":"Centre Hospitalier de L\u2019Universite de Montreal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6571-5531","authenticated-orcid":false,"given":"Richard H.","family":"Swartz","sequence":"additional","affiliation":[{"name":"Sunnybrook Health Sciences Centre"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1331-0695","authenticated-orcid":false,"given":"Jennifer L.","family":"Mandzia","sequence":"additional","affiliation":[{"name":"London Health Sciences Centre"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8696-5211","authenticated-orcid":false,"given":"Luciana","family":"Catanese","sequence":"additional","affiliation":[{"name":"McMaster University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3707-9723","authenticated-orcid":false,"given":"Jai","family":"Shankar","sequence":"additional","affiliation":[{"name":"University of Manitoba"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Yip","sequence":"additional","affiliation":[{"name":"The University of British Columbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5280-1542","authenticated-orcid":false,"given":"Steve","family":"Verreault","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Laval, Facult\u00e9 de M\u00e9decine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Medvedev","sequence":"additional","affiliation":[{"name":"Royal Columbian Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilavarasy","family":"Maran","sequence":"additional","affiliation":[{"name":"Trillium Health Partners"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed A.","family":"Al-Mekhlafi","sequence":"additional","affiliation":[{"name":"University of Calgary Cumming School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Fahed","sequence":"additional","affiliation":[{"name":"University of Ottawa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bijoy K.","family":"Menon","sequence":"additional","affiliation":[{"name":"University of Calgary Cumming School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2802-1626","authenticated-orcid":false,"given":"Ashkan","family":"Shoamanesh","sequence":"additional","affiliation":[{"name":"McMaster University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7276-9551","authenticated-orcid":false,"given":"Amy Y.X.","family":"Yu","sequence":"additional","affiliation":[{"name":"Sunnybrook Health Sciences Centre"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manraj (Raju) K. S","family":"Heran","sequence":"additional","affiliation":[{"name":"The University of British Columbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6269-1543","authenticated-orcid":false,"given":"Michael D.","family":"Hill","sequence":"additional","affiliation":[{"name":"University of Calgary Cumming School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Sharma","sequence":"additional","affiliation":[{"name":"McMaster University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Earl","sequence":"additional","affiliation":[{"name":"Canadian Stroke Consortium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4930-7789","authenticated-orcid":false,"given":"Andrew M.","family":"Demchuk","sequence":"additional","affiliation":[{"name":"University of Calgary Cumming School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8226-4883","authenticated-orcid":false,"given":"Grant","family":"Stotts","sequence":"additional","affiliation":[{"name":"University of Ottawa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1419-2635","authenticated-orcid":false,"given":"Alexandre Y.","family":"Poppe","sequence":"additional","affiliation":[{"name":"Centre Hospitalier de L\u2019Universite de Montreal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aristeidis","family":"Katsanos","sequence":"additional","affiliation":[{"name":"McMaster University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2026,10,14]]},"reference":[{"key":"S0317167126106763_ref7","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2024.1428198"},{"key":"S0317167126106763_ref16","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.123.064053"},{"key":"S0317167126106763_ref20","doi-asserted-by":"publisher","DOI":"10.1177\/1357633X231169115"},{"key":"S0317167126106763_ref19","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2022-068749"},{"key":"S0317167126106763_ref12","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.124.046690"},{"key":"S0317167126106763_ref17","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-84441-0"},{"key":"S0317167126106763_ref18","doi-asserted-by":"publisher","DOI":"10.1017\/cjn.2024.84"},{"key":"S0317167126106763_ref2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(08)70171-6"},{"key":"S0317167126106763_ref13","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2025.34275"},{"key":"S0317167126106763_ref15","doi-asserted-by":"publisher","DOI":"10.1186\/s42466-023-00237-9"},{"key":"S0317167126106763_ref5","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.1787"},{"key":"S0317167126106763_ref9","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.111.625046"},{"key":"S0317167126106763_ref3","doi-asserted-by":"publisher","DOI":"10.1017\/cjn.2022.344"},{"key":"S0317167126106763_ref21","first-page":"e000282","article-title":"Characterizing reasons for stroke thrombectomy ineligibility among potential candidates transferred in a hub-and-spoke network","volume":"2","author":"Regenhardt","year":"2022","journal-title":"Stroke Vasc Interv Neurol"},{"key":"S0317167126106763_ref4","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000003148"},{"key":"S0317167126106763_ref11","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg-2016-012291"},{"key":"S0317167126106763_ref8","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000269671.08423.14"},{"key":"S0317167126106763_ref14","doi-asserted-by":"publisher","DOI":"10.1159\/000345088"},{"key":"S0317167126106763_ref10","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2021.0023"},{"key":"S0317167126106763_ref1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.115.011721"},{"key":"S0317167126106763_ref6","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(06)70527-0"}],"container-title":["Canadian Journal of Neurological Sciences \/ Journal Canadien des Sciences Neurologiques"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0317167126106763","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T07:14:34Z","timestamp":1791962074000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0317167126106763\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,14]]},"references-count":21,"alternative-id":["S0317167126106763"],"URL":"https:\/\/doi.org\/10.1017\/cjn.2026.10676","relation":{},"ISSN":["0317-1671","2057-0155"],"issn-type":[{"value":"0317-1671","type":"print"},{"value":"2057-0155","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,14]]}}}