{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T11:47:47Z","timestamp":1792064867814,"version":"4.4.0"},"reference-count":42,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:00:00Z","timestamp":1792022400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Neurol. Sci."],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec id=\"S0317167126106891_as1\">\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>We sought to identify clinical and radiologic predictors of visual recovery and explore visual outcomes in patients who underwent transsphenoidal resection of pituitary neuroendocrine tumors (PitNETs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0317167126106891_as2\">\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Retrospective study of patients with PitNETs approaching\/contacting the chiasm at a tertiary neuro-ophthalmology practice. Clinical\/demographic\/MRI data were analyzed. Patients with a final visual acuity (VA) of at least 20\/40 and a final visual field mean deviation (VF MD) of \u22125 dB or better were defined as positive outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0317167126106891_as3\">\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      68 patients were analyzed, including 44 patients who underwent surgery and 24 who were observed during the study period. Of those who underwent surgery, patients with positive VA outcomes had better preoperative VA (logMAR 0.3 vs 1.3), VF MD (\u22128.1 vs \u221217.9 dB), thicker retinal nerve fiber layer (RNFL) (81.9 vs 69.5 \u00b5m) and ganglion cell complexes (GCC) (69.0 vs 50.5 \u00b5m) than those without. VF outcomes were predicted by better preoperative VA (logMAR 0.3 vs 0.7), VF MD (\u22127.4 vs \u221214.5 dB), thicker RNFL (84.1 vs 70.5 \u00b5m) and GCC (71.2 vs 55.6 \u00b5m) measurements and smaller tumor volume (8.4 vs 18.2 cm\n                      <jats:sup>3<\/jats:sup>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0317167126106891_as4\">\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Preoperative VA\/VF MD\/RNFL\/GCC thickness may predict visual outcomes after PitNET resection. Neuroradiologic factors failed to predict visual outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/cjn.2026.10689","type":"journal-article","created":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T10:55:05Z","timestamp":1792061705000},"page":"1-11","source":"Crossref","is-referenced-by-count":0,"title":["Predictors of Visual Outcomes in Pituitary Neuroendocrine Tumor Resection"],"prefix":"10.1017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3328-2115","authenticated-orcid":false,"given":"Marko (Chi-Wei)","family":"Tien","sequence":"first","affiliation":[{"name":"University of Toronto Department of Ophthalmology and Vision Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren","family":"Pickel","sequence":"additional","affiliation":[{"name":"University of Toronto Faculty of 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