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Sci."],"published-print":{"date-parts":[[2023]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t  <jats:p>We used Cerner Real-World Data\u2122, representing hospital admission records from 2020, to examine patients with co-occurring sickle cell disease and COVID-19 by discharge disposition grouped as death\/hospice versus transfers to other facilities, returned home, or left against medical advice. Among the death\/hospice group, we found older age and higher rates of congestive heart failure and diabetes. There were also significant differences in tachypnea, mechanical ventilation, minimum O<jats:sub>2<\/jats:sub> saturation, and length of stay with higher rates in the death\/hospice group. Awareness of such factors and associated mortality risks for this population may aid in patient care.<\/jats:p>","DOI":"10.1017\/cts.2023.577","type":"journal-article","created":{"date-parts":[[2023,6,16]],"date-time":"2023-06-16T07:54:34Z","timestamp":1686902074000},"source":"Crossref","is-referenced-by-count":1,"title":["COVID-19 in hospitalized adult patients with sickle cell disease: A 2020 US cohort using Cerner Real-World Data<sup>\u2122<\/sup> (CRWD)"],"prefix":"10.1017","volume":"7","author":[{"given":"Stephanie Howe","family":"Guarino","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0630-5107","authenticated-orcid":false,"given":"Kimberly D.","family":"Williams","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard J.","family":"Caplan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitch","family":"Fawcett","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophie","family":"Lanzkron","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2023,6,16]]},"reference":[{"key":"S2059866123005770_ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.dib.2022.108120"},{"key":"S2059866123005770_ref8"},{"key":"S2059866123005770_ref19","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp2022125"},{"key":"S2059866123005770_ref4","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)30193-9"},{"key":"S2059866123005770_ref14","unstructured":"14. Center for Drug Evaluation and Research. Combined cross-discipline team leader, division director, and ODE director summary review for NDA 214787 (remdesivir). 2020."},{"volume-title":"FDA Takes Key Action in Fight Against COVID-19 by Issuing Emergency Use Authorization for First COVID-19 Vaccine - December 11, 2020","year":"2020","key":"S2059866123005770_ref17"},{"key":"S2059866123005770_ref12","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V126.23.3260.3260"},{"key":"S2059866123005770_ref16","unstructured":"16. Center for Drug Evaluation and Research. Emergency use authorization (EUA) for remdesivir, an unapproved product [Internet], Washington, DC, 2020. (https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/nda\/2020\/EUA%20Review%20Remdesivir_050120.pdf)"},{"key":"S2059866123005770_ref3","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2018.10"},{"key":"S2059866123005770_ref1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1510865"},{"key":"S2059866123005770_ref5","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)61029-X"},{"key":"S2059866123005770_ref2","unstructured":"2. Centers for Disease Control and Prevention National Center on Birth Defects and Developmental Disabilities. Data & statistics on sickle cell disease [Internet], 2022 [cited October 14, 2022]. (https:\/\/www.cdc.gov\/ncbddd\/sicklecell\/data.html#:\u223c:text=SCD\u00a0affects\u00a0approximately\u00a0100%2C000\u00a0Americans,sickle\u00a0cell\u00a0trait\u00a0(SCT))"},{"key":"S2059866123005770_ref11","doi-asserted-by":"publisher","DOI":"10.29245\/2572-9411\/2017\/4.1124"},{"key":"S2059866123005770_ref18","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6950e2"},{"key":"S2059866123005770_ref13","doi-asserted-by":"publisher","DOI":"10.1111\/voxs.12047"},{"key":"S2059866123005770_ref15","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp2032369"},{"key":"S2059866123005770_ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.annemergmed.2020.08.009"},{"key":"S2059866123005770_ref6","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2019.15374"},{"key":"S2059866123005770_ref9","doi-asserted-by":"publisher","DOI":"10.3201\/eid2610.202792"}],"container-title":["Journal of Clinical and Translational Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S2059866123005770","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,14]],"date-time":"2023-07-14T09:28:11Z","timestamp":1689326891000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S2059866123005770\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023]]},"references-count":19,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023]]}},"alternative-id":["S2059866123005770"],"URL":"https:\/\/doi.org\/10.1017\/cts.2023.577","relation":{},"ISSN":["2059-8661"],"issn-type":[{"type":"electronic","value":"2059-8661"}],"subject":[],"published":{"date-parts":[[2023]]},"article-number":"e152"}}