{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T19:09:44Z","timestamp":1787598584240,"version":"build-2736575974"},"reference-count":66,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2024,1,12]],"date-time":"2024-01-12T00:00:00Z","timestamp":1705017600000},"content-version":"unspecified","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Clin. Trans. Sci."],"published-print":{"date-parts":[[2024]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S2059866123007045_as1\"><jats:title>Introduction:<\/jats:title><jats:p>Adverse childhood experiences (ACEs) are a measure of childhood adversity and are associated with life-long morbidity. The impacts of ACEs on peripartum health including preeclampsia, a common and dangerous hypertensive disorder of pregnancy, remain unclear, however. Therefore, we aimed to determine ACE association with peripartum psychiatric health and prevalence of preeclampsia using a case\u2013control design.<\/jats:p><\/jats:sec><jats:sec id=\"S2059866123007045_as2\"><jats:title>Methods:<\/jats:title><jats:p>Clinical data were aggregated and validated using a large, intergenerational knowledgebase developed at our institution. Depression symptoms were measured by standard clinical screeners: the Patient Health Questionnaire-9 (PHQ-9) and the Edinburgh Postnatal Depression Scale (EPDS). ACEs were assessed via survey. Scores were compared between participants with (<jats:italic>N<\/jats:italic>= 32) and without (<jats:italic>N<\/jats:italic>= 46) prior preeclampsia.<\/jats:p><\/jats:sec><jats:sec id=\"S2059866123007045_as3\"><jats:title>Results:<\/jats:title><jats:p>Participants with ACE scores \u22654 had significantly greater odds of preeclampsia than those with scores \u2264 3 (adjusted odds ratio = 6.71, 95% confidence interval:1.13\u201340.00;<jats:italic>p<\/jats:italic>= 0.037). Subsequent speculative analyses revealed that increased odds of preeclampsia may be driven by increased childhood abuse and neglect dimensions of the ACE score. PHQ-9 scores (3.73 vs. 1.86,<jats:italic>p<\/jats:italic>= 0.03), EPDS scores (6.38 vs. 3.71,<jats:italic>p<\/jats:italic>= 0.01), and the incidence of depression (37.5% vs. 23.9%,<jats:italic>p<\/jats:italic>= 0.05) were significantly higher in participants with a history of preeclampsia versus controls.<\/jats:p><\/jats:sec><jats:sec id=\"S2059866123007045_as4\"><jats:title>Conclusions:<\/jats:title><jats:p>Childhood sets the stage for life-long health. Our findings suggest that ACEs may be a risk factor for preeclampsia and depression, uniting the developmental origins of psychiatric and obstetric risk.<\/jats:p><\/jats:sec>","DOI":"10.1017\/cts.2023.704","type":"journal-article","created":{"date-parts":[[2024,1,12]],"date-time":"2024-01-12T09:16:24Z","timestamp":1705050984000},"source":"Crossref","is-referenced-by-count":4,"title":["A role for adverse childhood experiences and depression in 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