{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T00:28:05Z","timestamp":1759883285391,"version":"build-2065373602"},"reference-count":20,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"unspecified","delay-in-days":212,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Clin. Trans. Sci."],"published-print":{"date-parts":[[2025]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t  <jats:sec id=\"S2059866125101131_as1\">\n\t    <jats:title>Introduction:<\/jats:title>\n\t    <jats:p>Understanding how different symptoms co-occur and are correlated may provide insights into the pathophysiology of disease. The lack of group-to-individual generalizability of co-occurrence of symptoms was recently demonstrated by comparing intra-individual and inter-individual correlations in several psychological studies. Here, we investigate this phenomenon for lower urinary tract symptoms (LUTS).<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S2059866125101131_as2\">\n\t    <jats:title>Methods:<\/jats:title>\n\t    <jats:p>We analyzed data collected in the Symptoms of Lower Urinary Tract Dysfunction Research Network Recall Study. Participants responded to questions about their urinary symptoms for 25 consecutive days. These questions queried urologic symptoms including storage (urinary urgency, frequency, nocturia, and urinary incontinence), voiding (slow\/weak stream), and post-micturition (incomplete emptying and post-micturition dribble) symptoms. We calculated Pearson correlation coefficients and cosine similarity measures and compared distributions of intra-individual and inter-individual (cohort) metrics.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S2059866125101131_as3\">\n\t    <jats:title>Results:<\/jats:title>\n\t    <jats:p>Among 234 participants, distributions of intra-individual measures were 10-fold wider than those of inter-individual correlations. There are pairs of questions with distributions of correlations and cosine similarities containing individuals with extreme positive (&gt;0.8) and extreme negative values (&lt;\u20130.8). There are groups of participants with strong positive and negative correlations of urinary frequency and nocturia, urinary incontinence and weak flow, as well as strong negative and positive correlations of urinary frequency and dribbling. Information on these extreme groups is averaged out and lost in the inter-individual correlations.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S2059866125101131_as4\">\n\t    <jats:title>Conclusions:<\/jats:title>\n\t    <jats:p>Lack of group-to-individual generalizability previously shown for psychological symptoms is confirmed for LUTS. Wealth of information on the co-occurrence and co-evolution of LUTS in the intra-individual correlations and cosine similarities corroborates heterogeneity of LUTS and can be useful for deep phenotyping and for identifying personalized treatments of LUTS.<\/jats:p>\n\t  <\/jats:sec>","DOI":"10.1017\/cts.2025.10113","type":"journal-article","created":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T05:48:02Z","timestamp":1754027282000},"source":"Crossref","is-referenced-by-count":0,"title":["Lack of group-to-individual generalizability in people with lower urinary tract symptoms emphasizes the need for deep phenotyping and personalized treatments"],"prefix":"10.1017","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3812-1230","authenticated-orcid":false,"given":"Victor P.","family":"Andreev","sequence":"first","affiliation":[{"name":"Arbor Research Collaborative for Health"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline","family":"Smerdon","sequence":"additional","affiliation":[{"name":"Arbor Research Collaborative for Health"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian","family":"Bieber","sequence":"additional","affiliation":[{"name":"Arbor Research Collaborative for Health"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abigail R.","family":"Smith","sequence":"additional","affiliation":[{"name":"Northwestern University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathryn","family":"Flynn","sequence":"additional","affiliation":[{"name":"Medical College of Wisconsin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. Quentin","family":"Clemens","sequence":"additional","affiliation":[{"name":"University of Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Cella","sequence":"additional","affiliation":[{"name":"Northwestern University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claire C.","family":"Yang","sequence":"additional","affiliation":[{"name":"University of Washington School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ziya","family":"Kirkali","sequence":"additional","affiliation":[{"name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0624-7448","authenticated-orcid":false,"given":"Kevin","family":"Weinfurt","sequence":"additional","affiliation":[{"name":"Duke University School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"the LURN study group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2025,8,1]]},"reference":[{"key":"S2059866125101131_ref10","first-page":"1023","article-title":"Baseline lower urinary tract symptoms in patients enrolled in LURN: a prospective, observational cohort study","volume":"199","author":"Cameron","year":"2018","journal-title":"JUrol"},{"key":"S2059866125101131_ref16","doi-asserted-by":"publisher","DOI":"10.1002\/nau.25596"},{"key":"S2059866125101131_ref2","first-page":"201","article-title":"A manifesto on psychology as idiographic science: bringing the person back into scientific psychology, this time forever","volume":"2","author":"Molenaar","year":"2004","journal-title":"Meas- Interdiscip Res"},{"key":"S2059866125101131_ref12","doi-asserted-by":"publisher","DOI":"10.1097\/JU.0000000000000140"},{"key":"S2059866125101131_ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2018.06.068"},{"key":"S2059866125101131_ref20","doi-asserted-by":"publisher","DOI":"10.1097\/MLR.0000000000001111"},{"key":"S2059866125101131_ref6","doi-asserted-by":"publisher","DOI":"10.1002\/nau.21202"},{"key":"S2059866125101131_ref18","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1818675116"},{"key":"S2059866125101131_ref8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2009.08427.x"},{"key":"S2059866125101131_ref15","doi-asserted-by":"publisher","DOI":"10.1097\/JU.0000000000000354"},{"key":"S2059866125101131_ref1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-8721.2009.01619.x"},{"key":"S2059866125101131_ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2006.09.019"},{"key":"S2059866125101131_ref11","doi-asserted-by":"publisher","DOI":"10.1097\/JU.0000000000000310"},{"key":"S2059866125101131_ref17","doi-asserted-by":"publisher","DOI":"10.1002\/nau.25566"},{"key":"S2059866125101131_ref3","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1711978115"},{"key":"S2059866125101131_ref5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-1241.2010.02450.x"},{"key":"S2059866125101131_ref19","doi-asserted-by":"publisher","DOI":"10.4065\/77.4.384"},{"key":"S2059866125101131_ref13","doi-asserted-by":"publisher","DOI":"10.1111\/j.2517-6161.1995.tb02031.x"},{"key":"S2059866125101131_ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2016.01.007"},{"key":"S2059866125101131_ref7","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0268547"}],"container-title":["Journal of Clinical and Translational Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S2059866125101131","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T16:13:27Z","timestamp":1759853607000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S2059866125101131\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":20,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025]]}},"alternative-id":["S2059866125101131"],"URL":"https:\/\/doi.org\/10.1017\/cts.2025.10113","relation":{},"ISSN":["2059-8661"],"issn-type":[{"type":"electronic","value":"2059-8661"}],"subject":[],"published":{"date-parts":[[2025]]},"article-number":"e192"}}