{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T00:27:09Z","timestamp":1759883229082,"version":"build-2065373602"},"reference-count":41,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T00:00:00Z","timestamp":1756771200000},"content-version":"unspecified","delay-in-days":244,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Clin. Trans. Sci."],"published-print":{"date-parts":[[2025]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t  <jats:sec id=\"S205986612510143X_as1\">\n\t    <jats:title>Introduction:<\/jats:title>\n\t    <jats:p>Community-acquired bacterial pneumonia (CABP) contributes significantly to mortality and healthcare costs worldwide. The use of guideline-concordant antibiotic therapy for CABP is associated with improved outcomes.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S205986612510143X_as2\">\n\t    <jats:title>Methods:<\/jats:title>\n\t    <jats:p>This was a retrospective cohort study of inpatients with CABP due to MRSA or <jats:italic>P. aeruginosa<\/jats:italic> in the <jats:italic>All of Us<\/jats:italic> database. The proportion of patients on guideline-concordant antibiotics or guideline-discordant antibiotics was compared within groups based upon patient age, sex, self-reported race, ethnicity, marital status, alcohol use, and tobacco use. Guideline concordance was determined using the 2019 IDSA\/ATS CABP guidelines. Associations were further analyzed using multivariate logistic regression.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S205986612510143X_as3\">\n\t    <jats:title>Results:<\/jats:title>\n\t    <jats:p>A total of 336 patients with CABP due to MRSA (152) or <jats:italic>P. aeruginosa<\/jats:italic> (184) were included. Guideline-concordant antibiotic therapy was prescribed to 70% of CABP-MRSA patients and for 57% of CABP-<jats:italic>P. aeruginosa<\/jats:italic> patients. Independently predictive factors of guideline-concordant antibiotic prescribing for CABP-<jats:italic>P. aeruginosa<\/jats:italic> patients were Non-Hispanic Black (NHB) vs. Non-Hispanic White (NHW) race (odds ratio = 0.30, 95% confidence interval = 0.12 \u2013 0.75).<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S205986612510143X_as4\">\n\t    <jats:title>Conclusion:<\/jats:title>\n\t    <jats:p>In the <jats:italic>All of Us<\/jats:italic> database, the majority of CABP-MRSA and CABP-<jats:italic>P. aeruginosa<\/jats:italic> patients were prescribed guideline-concordant antibiotic therapy. Race was independently predictive of guideline-concordant antibiotic therapy for patients with CABP-<jats:italic>P. aeruginosa<\/jats:italic>, but not CABP-MRSA. NHB patients were less likely to receive guideline-concordant antibiotic therapy than NHW patients when treated for CABP-<jats:italic>P. aeruginosa.<\/jats:italic><\/jats:p>\n\t  <\/jats:sec>","DOI":"10.1017\/cts.2025.10143","type":"journal-article","created":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T06:45:37Z","timestamp":1756795537000},"source":"Crossref","is-referenced-by-count":0,"title":["Guideline-concordant antibiotic prescribing for community-acquired bacterial pneumonia (CABP) due to drug-resistant pathogens in the <i>All of Us<\/i> database"],"prefix":"10.1017","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3847-3674","authenticated-orcid":false,"given":"Corbyn M.","family":"Gilmore","sequence":"first","affiliation":[{"name":"The University of Texas at Austin"},{"name":"University of Texas Health Science Center at San Antonio"},{"name":"University of Texas Health San Antonio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriana","family":"Vargus","sequence":"additional","affiliation":[{"name":"The University of Texas at Austin"},{"name":"University of Texas Health Science Center at San Antonio"},{"name":"University of Texas Health San Antonio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grace C.","family":"Lee","sequence":"additional","affiliation":[{"name":"The University of Texas at Austin"},{"name":"University of Texas Health Science Center at San Antonio"},{"name":"South Texas Veterans Health Care System"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7684-1648","authenticated-orcid":false,"given":"Susanne","family":"Schmidt","sequence":"additional","affiliation":[{"name":"University of Texas Health Science Center at San Antonio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelly R.","family":"Reveles","sequence":"additional","affiliation":[{"name":"The University of Texas at Austin"},{"name":"University of Texas Health Science Center at San Antonio"},{"name":"University of Texas Health San Antonio"},{"name":"South Texas Veterans Health Care System"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos A.","family":"Alvarez","sequence":"additional","affiliation":[{"name":"Jerry H. Hodge School of Pharmacy"},{"name":"Texas Tech University Health Science Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0692-4787","authenticated-orcid":false,"given":"Christopher R.","family":"Frei","sequence":"additional","affiliation":[{"name":"The University of Texas at Austin"},{"name":"University of Texas Health Science Center at San Antonio"},{"name":"University of Texas Health San Antonio"},{"name":"South Texas Veterans Health Care System"},{"name":"University Hospital"},{"name":"San Antonio Regional Campus"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2025,9,2]]},"reference":[{"key":"S205986612510143X_ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2010.02.006"},{"key":"S205986612510143X_ref16","doi-asserted-by":"publisher","DOI":"10.1007\/s41669-020-00240-9"},{"key":"S205986612510143X_ref5","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics12121685"},{"key":"S205986612510143X_ref28","doi-asserted-by":"publisher","DOI":"10.1017\/ash.2024.472"},{"key":"S205986612510143X_ref35","unstructured":"35. Data Sources \u2013 All of Us, Research Hub. (https:\/\/www.researchallofus.org\/data-tools\/data-sources\/) Accessed November 14, 2024."},{"key":"S205986612510143X_ref24","doi-asserted-by":"publisher","DOI":"10.1086\/423960"},{"volume-title":"Antibiotic resistance threats in the United States, 2019","year":"2019","key":"S205986612510143X_ref6"},{"key":"S205986612510143X_ref27","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciq146"},{"key":"S205986612510143X_ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2019.10.101"},{"volume-title":"StatPearls [Internet]","year":"2025","author":"Siddiqui","key":"S205986612510143X_ref25"},{"key":"S205986612510143X_ref41","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268807008564"},{"key":"S205986612510143X_ref14","doi-asserted-by":"publisher","DOI":"10.1080\/03007995.2019.1675149"},{"key":"S205986612510143X_ref34","unstructured":"34. User Support. How to comply with the All of Us, Data and Statistics Dissemination Policy, (https:\/\/support.researchallofus.org\/hc\/en-us\/articles\/360043016291-How-to-comply-with-the-All-of-Us-Data-and-Statistics-Dissemination-Policy) Accessed January 23, 2023."},{"key":"S205986612510143X_ref37","first-page":"e132","article-title":"Antibiotic prescribing by age, sex, race, and ethnicity for patients admitted to the hospital with community-acquired bacterial pneumonia (CABP) in the All of Us database","volume":"7","author":"Gilmore","year":"2023","journal-title":"J Clin Transl Sci"},{"key":"S205986612510143X_ref30","unstructured":"30. About. All of Us research program | NIH. 2020, (https:\/\/allofus.nih.gov\/about) Accessed November 14, 2024."},{"key":"S205986612510143X_ref11","doi-asserted-by":"publisher","DOI":"10.1097\/QCO.0000000000000813"},{"key":"S205986612510143X_ref31","unstructured":"31. Data Snapshots \u2013 All of Us research hub. (https:\/\/www.researchallofus.org\/data-tools\/data-snapshots\/) Accessed May 20, 2025."},{"key":"S205986612510143X_ref26","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.201906-459OC"},{"key":"S205986612510143X_ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2022.12.035"},{"key":"S205986612510143X_ref36","unstructured":"36. Data Access Tiers \u2013 All of Us, Research Hub. (https:\/\/www.researchallofus.org\/data-tools\/data-access\/) Accessed November 14, 2024."},{"key":"S205986612510143X_ref40","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2020.7750"},{"key":"S205986612510143X_ref33","unstructured":"33. All of Us Research Program. Race and ethnicity data collection and transformation. All of Us research program, (https:\/\/support.researchallofus.org\/hc\/en-us\/articles\/360039299632-Race-and-Ethnicity-Data-Collection-and-Transformation) Accessed June 4, 2025."},{"key":"S205986612510143X_ref29","unstructured":"29. AAPC. ICD-10-CM code J15.212 \u2013 pneumonia due to methicillin resistant Staphylococcus aureus. AAPC, (https:\/\/www.aapc.com\/codes\/icd-10-codes\/J15.212) Accessed June 4, 2025."},{"volume-title":"Global action plan on antimicrobial resistance","year":"2015","key":"S205986612510143X_ref4"},{"key":"S205986612510143X_ref32","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw353"},{"key":"S205986612510143X_ref10","doi-asserted-by":"publisher","DOI":"10.1183\/16000617.0117-2023"},{"key":"S205986612510143X_ref39","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6963-4-20"},{"key":"S205986612510143X_ref17","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201908-1581ST"},{"key":"S205986612510143X_ref12","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2024.14796"},{"key":"S205986612510143X_ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2006.02.014"},{"key":"S205986612510143X_ref7","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)02724-0"},{"key":"S205986612510143X_ref8","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(16)30267-5"},{"key":"S205986612510143X_ref2","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics12010051"},{"key":"S205986612510143X_ref38","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6963-10-143"},{"key":"S205986612510143X_ref9","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01190-2017"},{"key":"S205986612510143X_ref3","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofad440"},{"key":"S205986612510143X_ref1","doi-asserted-by":"publisher","DOI":"10.7189\/jogh.15.04023"},{"key":"S205986612510143X_ref15","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cix647"},{"key":"S205986612510143X_ref19","doi-asserted-by":"publisher","DOI":"10.1001\/archinternmed.2009.259"},{"key":"S205986612510143X_ref21","doi-asserted-by":"publisher","DOI":"10.1001\/archinternmed.2009.265"},{"key":"S205986612510143X_ref18","doi-asserted-by":"publisher","DOI":"10.1186\/s12911-016-0270-y"}],"container-title":["Journal of Clinical and Translational Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S205986612510143X","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T16:18:15Z","timestamp":1759853895000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S205986612510143X\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":41,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025]]}},"alternative-id":["S205986612510143X"],"URL":"https:\/\/doi.org\/10.1017\/cts.2025.10143","relation":{},"ISSN":["2059-8661"],"issn-type":[{"type":"electronic","value":"2059-8661"}],"subject":[],"published":{"date-parts":[[2025]]},"article-number":"e214"}}