{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T06:57:37Z","timestamp":1789541857932,"version":"build-2803163510"},"reference-count":22,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2015,12,18]],"date-time":"2015-12-18T00:00:00Z","timestamp":1450396800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Disaster med. public health prep."],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We conducted a systematic review of the 2012\u20132013 multistate fungal meningitis epidemic in the United States from the perspectives of clinical response, outbreak investigation, and epidemiology. Articles focused on clinical response, outbreak investigation, and epidemiology were included, whereas articles focused on compounding pharmacies, legislation and litigation, diagnostics, microbiology, and pathogenesis were excluded. We reviewed 19 articles by use of the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) framework. The source of the fungal meningitis outbreak was traced to the New England Compounding Center in Massachusetts, where injectable methylprednisolone acetate products were contaminated with the predominant pathogen, <jats:italic>Exserohilum rostratum<\/jats:italic>. As of October 23, 2013, the final case count stood at 751 patients and 64 deaths, and no additional cases are anticipated. The multisectoral public health response to the fungal meningitis epidemic from the hospitals, clinics, pharmacies, and the public health system at the local, state, and federal levels led to an efficient epidemiological investigation to trace the outbreak source and rapid implementation of multiple response plans. This systematic review reaffirms the effective execution of a multisectoral public health response and efficient delivery of the core functions of public health assessment, policy development, and service assurances to improve population health.(<jats:italic>Disaster Med Public Health Preparedness<\/jats:italic>. 2016;10:145\u2013151)<\/jats:p>","DOI":"10.1017\/dmp.2015.137","type":"journal-article","created":{"date-parts":[[2015,12,18]],"date-time":"2015-12-18T09:40:48Z","timestamp":1450431648000},"page":"145-151","source":"Crossref","is-referenced-by-count":33,"title":["Clinical Response, Outbreak Investigation, and Epidemiology of the Fungal Meningitis Epidemic in the United States: Systematic Review"],"prefix":"10.1017","volume":"10","author":[{"given":"Kaja M.","family":"Abbas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nargesalsadat","family":"Dorratoltaj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret L.","family":"O\u2019Dell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paige","family":"Bordwine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas M.","family":"Kerkering","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerry J.","family":"Redican","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2015,12,18]]},"reference":[{"key":"S1935789315001378_ref22","volume-title":"The Future of the Public\u2019s Health in the 21st Century","year":"2002"},{"key":"S1935789315001378_ref16","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1304879"},{"key":"S1935789315001378_ref11","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofu022"},{"key":"S1935789315001378_ref2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1212972"},{"key":"S1935789315001378_ref20","unstructured":"CDC. Multistate outbreak of fungal meningitis and other infections. CDC website. http:\/\/www.cdc.gov\/hai\/outbreaks\/meningitis.html. Accessed April 30, 2015."},{"key":"S1935789315001378_ref4","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000097"},{"key":"S1935789315001378_ref12","doi-asserted-by":"publisher","DOI":"10.1097\/QCO.0000000000000013"},{"key":"S1935789315001378_ref8","article-title":"Battlefront. Michigan hospital at forefront in national fight against outbreak from tainted injections","volume":"42","author":"McKinney","year":"2012","journal-title":"Mod Healthc"},{"key":"S1935789315001378_ref13","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.526"},{"key":"S1935789315001378_ref5","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1212617"},{"key":"S1935789315001378_ref6","first-page":"2024","article-title":"Meningitis outbreak challenges hospital pharmacies","volume":"69","author":"Traynor","year":"2012","journal-title":"Am J Health Syst Pharm"},{"key":"S1935789315001378_ref14","doi-asserted-by":"publisher","DOI":"10.1097\/01.NAJ.0000426691.81083.93"},{"key":"S1935789315001378_ref15","doi-asserted-by":"publisher","DOI":"10.1097\/PHH.0b013e318294e603"},{"key":"S1935789315001378_ref3","article-title":"Multistate fungal meningitis outbreak\u2014interim guidance for treatment","volume":"61","year":"2012","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"S1935789315001378_ref21","volume-title":"The Future of Public Health","year":"1988"},{"key":"S1935789315001378_ref18","first-page":"377","article-title":"Spinal and paraspinal infections associated with contaminated methylprednisolone acetate injections - Michigan, 2012-2013","volume":"62","year":"2013","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"S1935789315001378_ref10","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.6293"},{"key":"S1935789315001378_ref19","first-page":"800","article-title":"Notes from the field: department of Defense response to a multistate outbreak of fungal meningitis\u2014United States, October 2012","volume":"62","year":"2013","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"S1935789315001378_ref1","first-page":"839","article-title":"Multistate outbreak of fungal infection associated with injection of methylprednisolone acetate solution from a single compounding pharmacy - United States, 2012","volume":"61","year":"2012","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"S1935789315001378_ref17","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1213978"},{"key":"S1935789315001378_ref9","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2012.187705"},{"key":"S1935789315001378_ref7","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-158-3-201302050-00568"}],"container-title":["Disaster Medicine and Public Health Preparedness"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S1935789315001378","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,19]],"date-time":"2019-04-19T22:55:15Z","timestamp":1555714515000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S1935789315001378\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12,18]]},"references-count":22,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,2]]}},"alternative-id":["S1935789315001378"],"URL":"https:\/\/doi.org\/10.1017\/dmp.2015.137","relation":{},"ISSN":["1935-7893","1938-744X"],"issn-type":[{"value":"1935-7893","type":"print"},{"value":"1938-744X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,12,18]]}}}