{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T08:19:42Z","timestamp":1775117982527,"version":"3.50.1"},"reference-count":18,"publisher":"Cambridge University Press (CUP)","issue":"4","license":[{"start":{"date-parts":[[2016,9,20]],"date-time":"2016-09-20T00:00:00Z","timestamp":1474329600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Disaster med. public health prep."],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S1935789316001208_abs1\" sec-type=\"general\"><jats:title>Objective<\/jats:title><jats:p>Human adenovirus type 55 (HAdV-55) has recently caused multiple outbreaks. This study examined polymorphisms in CD46 to determine their involvement in HAdV-55 infection.<\/jats:p><\/jats:sec><jats:sec id=\"S1935789316001208_abs2\" sec-type=\"methods\"><jats:title>Methods<\/jats:title><jats:p>A total of 214 study subjects infected with HAdV-55 were included in our study. The study subjects were divided into those with silent infections (n=91), minor infections (n=85), and severe infections (n=38). Ten single nucleotide polymorphisms (SNPs) from CD46 were examined.<\/jats:p><\/jats:sec><jats:sec id=\"S1935789316001208_abs3\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>Compared with the <jats:italic>AA<\/jats:italic> genotype, the <jats:italic>TT<\/jats:italic> genotype at rs2724385 (CD46, <jats:italic>A\/T<\/jats:italic>) was associated with a protective effect against disease occurrence, with an odds ratio (95% confidence interval) of 0.20 (0.04-0.97) (<jats:italic>P<\/jats:italic>=0.038). There were no significant differences between the patients with minor and severe infection and those who had silent HAdV-55 infection in the other CD46 SNPs. We next compared the polymorphisms of these genes according to disease severity in HAdV-55-infected patients with clinical symptoms. The results showed that there were no significant differences between minor infections and severe infections.<\/jats:p><\/jats:sec><jats:sec id=\"S1935789316001208_abs4\" sec-type=\"conclusions\"><jats:title>Conclusions<\/jats:title><jats:p>Our results suggested that the CD46 SNP at rs2724385 is associated with the occurrence of disease in HAdV-55-infected patients. A much larger number of samples is required to understand the role of CD46 polymorphisms in the occurrence and progression of infection by HAdV-55. (<jats:italic>Disaster Med Public Health Preparedness<\/jats:italic>. 2018;12:427\u2013430)<\/jats:p><\/jats:sec>","DOI":"10.1017\/dmp.2016.120","type":"journal-article","created":{"date-parts":[[2016,9,20]],"date-time":"2016-09-20T09:16:46Z","timestamp":1474363006000},"page":"427-430","source":"Crossref","is-referenced-by-count":1,"title":["Role of CD46 Polymorphisms in the Occurrence of Disease in Young Chinese Men With Human Adenovirus Type 55 Infection"],"prefix":"10.1017","volume":"12","author":[{"given":"Qi","family":"Lv","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Ding","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zi-quan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong-wei","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bao-guo","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhou-wei","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao-jun","family":"Fan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shi-ke","family":"Hou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2016,9,20]]},"reference":[{"key":"S1935789316001208_ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2012.04.018"},{"key":"S1935789316001208_ref5","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01694-09"},{"key":"S1935789316001208_ref14","doi-asserted-by":"publisher","DOI":"10.1086\/320146"},{"key":"S1935789316001208_ref10","doi-asserted-by":"publisher","DOI":"10.3109\/08830185.2013.823420"},{"key":"S1935789316001208_ref8","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-14-147"},{"key":"S1935789316001208_ref17","doi-asserted-by":"publisher","DOI":"10.1016\/S1357-2725(99)00092-8"},{"key":"S1935789316001208_ref12","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-84-20714"},{"key":"S1935789316001208_ref6","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01769-08"},{"key":"S1935789316001208_ref11","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.83142-0"},{"key":"S1935789316001208_ref16","doi-asserted-by":"publisher","DOI":"10.1126\/science.286.5444.1579"},{"key":"S1935789316001208_ref15","doi-asserted-by":"publisher","DOI":"10.1126\/science.275.5304.1320"},{"key":"S1935789316001208_ref18","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.78.9.4454-4462.2004"},{"key":"S1935789316001208_ref3","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a121632"},{"key":"S1935789316001208_ref13","first-page":"2149","article-title":"Adenoviruses","volume":"2","author":"Horwitz","year":"2001","journal-title":"Field Virol"},{"key":"S1935789316001208_ref4","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.20441"},{"key":"S1935789316001208_ref9","first-page":"45","article-title":"Clinical characteristics of 80 hospitalized cases of human adenovirus type 55 infection","volume":"26","author":"Xie","year":"2013","journal-title":"Infect Dis Info"},{"key":"S1935789316001208_ref1","doi-asserted-by":"publisher","DOI":"10.1002\/rmv.589"},{"key":"S1935789316001208_ref2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00354-11"}],"container-title":["Disaster Medicine and Public Health Preparedness"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S1935789316001208","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,13]],"date-time":"2019-04-13T22:45:36Z","timestamp":1555195536000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S1935789316001208\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9,20]]},"references-count":18,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,8]]}},"alternative-id":["S1935789316001208"],"URL":"https:\/\/doi.org\/10.1017\/dmp.2016.120","relation":{},"ISSN":["1935-7893","1938-744X"],"issn-type":[{"value":"1935-7893","type":"print"},{"value":"1938-744X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,9,20]]}}}