{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,2]],"date-time":"2023-09-02T22:28:37Z","timestamp":1693693717693},"reference-count":25,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2017,6,5]],"date-time":"2017-06-05T00:00:00Z","timestamp":1496620800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Disaster med. public health prep."],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S1935789317000325_abs1\" sec-type=\"general\"><jats:title>Objective<\/jats:title><jats:p>We evaluated the effectiveness and cost of a fungal meningitis outbreak response in the New River Valley of Virginia during 2012-2013 from the perspective of the local public health department and clinical facilities. The fungal meningitis outbreak affected 23 states in the United States with 751 cases and 64 deaths in 20 states; there were 56 cases and 5 deaths in Virginia.<\/jats:p><\/jats:sec><jats:sec id=\"S1935789317000325_abs2\" sec-type=\"methods\"><jats:title>Methods<\/jats:title><jats:p>We conducted a partial economic evaluation of the fungal meningitis outbreak response in New River Valley. We collected costs associated with the local health department and clinical facilities in the outbreak response and estimated the epidemiological effectiveness by using disability-adjusted life years (DALYs) averted.<\/jats:p><\/jats:sec><jats:sec id=\"S1935789317000325_abs3\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>We estimated the epidemiological effectiveness of this outbreak response to be 153 DALYs averted among the patients, and the costs incurred by the local health department and clinical facilities to be $30,413 and $39,580, respectively.<\/jats:p><\/jats:sec><jats:sec id=\"S1935789317000325_abs4\" sec-type=\"conclusions\"><jats:title>Conclusions<\/jats:title><jats:p>We estimated the incremental cost-effectiveness ratio of $198 per DALY averted and $258 per DALY averted from the local health department and clinical perspectives, respectively, thereby assisting in impact evaluation of the outbreak response by the local health department and clinical facilities. (<jats:italic>Disaster Med Public Health Preparedness<\/jats:italic>. 2018;12:38\u201346)<\/jats:p><\/jats:sec>","DOI":"10.1017\/dmp.2017.32","type":"journal-article","created":{"date-parts":[[2017,6,5]],"date-time":"2017-06-05T07:21:13Z","timestamp":1496647273000},"page":"38-46","source":"Crossref","is-referenced-by-count":2,"title":["Epidemiological Effectiveness and Cost of a Fungal Meningitis Outbreak Response in New River Valley, Virginia: Local Health Department and Clinical Perspectives"],"prefix":"10.1017","volume":"12","author":[{"given":"Nargesalsadat","family":"Dorratoltaj","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margaret L.","family":"O\u2019Dell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paige","family":"Bordwine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas M.","family":"Kerkering","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kerry J.","family":"Redican","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaja M.","family":"Abbas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2017,6,5]]},"reference":[{"key":"S1935789317000325_ref22","volume-title":"Fungal meningitis attack rate in Virginia based on epidural steroid injection lot numbers","year":"2015"},{"key":"S1935789317000325_ref3","first-page":"839","article-title":"Multistate outbreak of fungal infection associated with injection of methylprednisolone acetate solution from a single compounding pharmacy \u2013 United States, 2012","volume":"61","year":"2012","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"S1935789317000325_ref5","unstructured":"Centers for Disease Control and Prevention. Multistate Outbreak of Fungal Meningitis and Other Infections. http:\/\/www.cdc.gov\/hai\/outbreaks\/meningitis.html. CDC website. Accessed June 29, 2015."},{"key":"S1935789317000325_ref25","doi-asserted-by":"publisher","DOI":"10.1097\/PHH.0b013e318294e603"},{"key":"S1935789317000325_ref8","unstructured":"New River Health District, Virginia Department of Health. Virginia.gov website. http:\/\/www.vdh.virginia.gov\/LHD\/index.htm. Accessed July 12, 2015."},{"key":"S1935789317000325_ref20","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200105033441807"},{"key":"S1935789317000325_ref15","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)31678-6"},{"key":"S1935789317000325_ref19","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.42.1.236-238.2004"},{"key":"S1935789317000325_ref6","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-158-3-201302050-00568"},{"key":"S1935789317000325_ref17","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)31679-8"},{"key":"S1935789317000325_ref24","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.526"},{"key":"S1935789317000325_ref23","unstructured":"US Census Bureau. Life Expectancy. Statistical Abstract of the United States: 2012. https:\/\/www.census.gov\/library\/publications\/2011\/compendia\/statab\/131ed.html. Published 2012. Accessed May 4, 2017."},{"key":"S1935789317000325_ref11","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61689-4"},{"key":"S1935789317000325_ref7","doi-asserted-by":"publisher","DOI":"10.3201\/eid2106.141558"},{"key":"S1935789317000325_ref21","unstructured":"World Health Organization. The Global Burden of Disease: 2004 Update. http:\/\/www.who.int\/healthinfo\/global_burden_disease\/2004_report_update\/en\/. Published 2008. Accessed May 4, 2017."},{"key":"S1935789317000325_ref2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1212972"},{"key":"S1935789317000325_ref12","unstructured":"CDC. Exophiala infection from contaminated injectable steroids prepared by a compounding pharmacy --- United States, July--November 2002. (2002). MMWR Weekly. 51(49):1109-1112. http:\/\/www.cdc.gov\/mmwr\/preview\/mmwrhtml\/mm5149a1.htm. Published December 13, 2002. Accessed May 4, 2017."},{"key":"S1935789317000325_ref1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1213978"},{"key":"S1935789317000325_ref9","first-page":"21","article-title":"Economic evaluation of fungal meningitis outbreak response in New River Valley: local health department perspective","volume":"4","author":"Abbas","year":"2015","journal-title":"Front Public Health Serv Syst Res"},{"key":"S1935789317000325_ref18","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31823efca9"},{"key":"S1935789317000325_ref14","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)31012-1"},{"key":"S1935789317000325_ref4","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1212617"},{"key":"S1935789317000325_ref10","doi-asserted-by":"publisher","DOI":"10.1017\/dmp.2015.137"},{"key":"S1935789317000325_ref13"},{"key":"S1935789317000325_ref16","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)31460-X"}],"container-title":["Disaster Medicine and Public Health Preparedness"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S1935789317000325","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,15]],"date-time":"2019-04-15T20:37:27Z","timestamp":1555360647000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S1935789317000325\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,5]]},"references-count":25,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,2]]}},"alternative-id":["S1935789317000325"],"URL":"https:\/\/doi.org\/10.1017\/dmp.2017.32","relation":{},"ISSN":["1935-7893","1938-744X"],"issn-type":[{"value":"1935-7893","type":"print"},{"value":"1938-744X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6,5]]}}}