{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T03:00:47Z","timestamp":1770692447280,"version":"3.49.0"},"reference-count":74,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2024,2,22]],"date-time":"2024-02-22T00:00:00Z","timestamp":1708560000000},"content-version":"unspecified","delay-in-days":52,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Disaster med. public health prep."],"published-print":{"date-parts":[[2024]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t  <jats:p>Although chemical and radiological agents cause toxicity through different mechanisms, the multiorgan injuries caused by these threats share similarities that convene on the level of basic biological responses. This publication will discuss these areas of convergence and explore \u201cmulti-utility\u201d approaches that could be leveraged to address common injury mechanisms underlying actions of chemical and radiological agents in a threat-agnostic manner. In addition, we will provide an overview of the current state of radiological and chemical threat research, discuss the US Government\u2019s efforts toward medical preparedness, and identify potential areas for collaboration geared toward enhancing preparedness and response against radiological and chemical threats. We also will discuss previous regulatory experience to provide insight on how to navigate regulatory paths for US Food and Drug Administration (FDA) approval\/licensure\/clearance for products addressing chemical or radiological\/nuclear threats. This publication follows a 2022 trans-agency meeting titled, \u201cOverlapping Science in Radiation and Sulfur Mustard Exposures of Skin and Lung: Consideration of Models, Mechanisms, Organ Systems, and Medical Countermeasures,\u201d sponsored by the National Institute of Allergy and Infectious Diseases (NIAID), a part of the National Institutes of Health (NIH). Discussions from this meeting explored the overlapping nature of radiation and chemical injury and spurred increased interest in how preparedness for one threat leads to preparedness for the other. Herein, subject matter experts from the NIAID and the Biomedical Advanced Research and Development Authority (BARDA), a part of the Administration for Strategic Preparedness and Response (ASPR), summarize the knowledge gained from recently funded biomedical research, as well as insights from the 2022 meeting. These topics include identification of common areas for collaboration, potential use of biomarkers of injury to identify injuries caused by both hazards, and common and widely available treatments that could treat damage caused by radiological or chemical threats.<\/jats:p>","DOI":"10.1017\/dmp.2023.226","type":"journal-article","created":{"date-parts":[[2024,2,22]],"date-time":"2024-02-22T07:15:48Z","timestamp":1708586148000},"source":"Crossref","is-referenced-by-count":4,"title":["Radiation and Chemical Program Research for Multi-Utility and Repurposed Countermeasures: A US Department of Health and Human Services Agencies Perspective"],"prefix":"10.1017","volume":"18","author":[{"given":"Carmen I.","family":"Rios","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Efrain E.","family":"Garcia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"II","given":"Thomas S.","family":"Hogdahl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary J.","family":"Homer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Narayan V.","family":"Iyer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judith W.","family":"Laney","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shannon G.","family":"Loelius","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Merriline M.","family":"Satyamitra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea L.","family":"DiCarlo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2024,2,22]]},"reference":[{"key":"S1935789323002264_ref1","doi-asserted-by":"crossref","unstructured":"1. Yeung, DT , Harper, JR , Platoff, GE. The National Institutes of Health Chemical Countermeasures Research Program (NIH CCRP): a collaborative opportunity to develop effective and accessible chemical medical countermeasures for the American people. Drug Dev Res. Published online June 22, 2020. doi: 10.1002\/ddr.21707","DOI":"10.1002\/ddr.21707"},{"key":"S1935789323002264_ref2","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1021\/acs.chemrestox.0c00086","article-title":"Supporting fundamental chemical toxicology research to inform medical countermeasure developments: The National Institutes of Health Chemical Countermeasures Research Program","volume":"33","author":"Yeung","year":"2020","journal-title":"Chem Res Toxicol."},{"key":"S1935789323002264_ref19","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1667\/RR3255.1","article-title":"Curcumin for radiation dermatitis: a randomized, double-blind, placebo-controlled clinical trial of thirty breast cancer patients","volume":"180","author":"Ryan","year":"2013","journal-title":"Radiat Res."},{"key":"S1935789323002264_ref52","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1097\/HP.0000000000000357","article-title":"Delayed effects of acute radiation exposure in a murine model of the H-ARS: multiple-organ injury consequent to <10 Gy total body irradiation","volume":"109","author":"Unthank","year":"2015","journal-title":"Health Phys."},{"key":"S1935789323002264_ref6","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1667\/RR14436.1","article-title":"Understanding the pathophysiology and challenges of development of medical countermeasures for radiation-induced vascular\/endothelial cell injuries: report of a NIAID workshop, August 20, 2015","volume":"186","author":"Satyamitra","year":"2016","journal-title":"Radiat Res."},{"key":"S1935789323002264_ref12","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1667\/RR1485.1","article-title":"Medical countermeasures against nuclear threats: Radionuclide decorporation agents","volume":"170","author":"Cassatt","year":"2008","journal-title":"Radiat Res."},{"key":"S1935789323002264_ref22","first-page":"199","article-title":"Long-term complications of sulfur mustard exposure: a therapeutic update","volume":"153","author":"Shiyovich","year":"2014","journal-title":"Harefuah."},{"key":"S1935789323002264_ref29","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.taap.2004.03.013","article-title":"Reduced sulfur mustard-induced skin toxicity in cyclooxygenase-2 knockout and celecoxib-treated mice","volume":"200","author":"Wormser","year":"2004","journal-title":"Toxicol Appl Pharmacol."},{"key":"S1935789323002264_ref68","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1667\/RADE-21-00072.1","article-title":"Challenges and strategies in the development of radiation biodosimetry tests for patient management","volume":"196","author":"Satyamitra","year":"2021","journal-title":"Radiat Res."},{"key":"S1935789323002264_ref71","doi-asserted-by":"crossref","first-page":"419","DOI":"10.3109\/00365521.2013.772227","article-title":"Keratinocyte growth factor pretreatment prevents radiation-induced intestinal damage in a mouse model","volume":"48","author":"Cai","year":"2013","journal-title":"Scand J Gastroenterol."},{"key":"S1935789323002264_ref51","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1097\/HP.0b013e3182a4df10","article-title":"Survival efficacy of the PEGylated G-CSFs Maxy-G34 and neulasta in a mouse model of lethal H-ARS, and residual bone marrow damage in treated survivors","volume":"106","author":"Chua","year":"2014","journal-title":"Health Phys."},{"key":"S1935789323002264_ref73","first-page":"933","article-title":"Keratinocyte growth factor protects mice from chemotherapy and radiation-induced gastrointestinal injury and mortality","volume":"58","author":"Farrell","year":"1998","journal-title":"Cancer Res."},{"key":"S1935789323002264_ref39","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.intimp.2012.12.029","article-title":"Enhanced hematopoietic protection from radiation by the combination of genistein and captopril","volume":"15","author":"Day","year":"2013","journal-title":"Int Immunopharmacol."},{"key":"S1935789323002264_ref45","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1080\/15376516.2017.1320695","article-title":"Changes in the oxidative stress\/anti-oxidant system after exposure to sulfur mustard and antioxidant strategies in the therapy, a review","volume":"27","author":"Pohanka","year":"2017","journal-title":"Toxicol Mech Methods."},{"key":"S1935789323002264_ref64","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1186\/s13014-017-0865-1","article-title":"Modeling DNA damage-induced pneumopathy in mice: insight from danger signaling cascades","volume":"12","author":"Wirsd\u00f6rfer","year":"2017","journal-title":"Radiat Oncol."},{"key":"S1935789323002264_ref65","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1080\/08958378.2021.1951401","article-title":"A novel sulfur mustard (HD) vapor inhalation exposure model of pulmonary toxicity for the efficacy evaluation of candidate medical countermeasures","volume":"33","author":"Perry","year":"2021","journal-title":"Inhal Toxicol."},{"key":"S1935789323002264_ref66","doi-asserted-by":"crossref","first-page":"e106","DOI":"10.1093\/milmed\/usaa510","article-title":"A rodent model of sulfur mustard hematologic toxicity for the efficacy evaluation of candidate medical countermeasures","volume":"187","author":"Beske","year":"2022","journal-title":"Mil Med."},{"key":"S1935789323002264_ref36","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.radonc.2017.07.014","article-title":"Nintedanib reduces radiation-induced microscopic lung fibrosis but this cannot be monitored by CT imaging: a preclinical study with a high precision image-guided irradiator","volume":"124","author":"De Ruysscher","year":"2017","journal-title":"Radiother Oncol."},{"key":"S1935789323002264_ref41","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1111\/j.1440-1843.2011.02092.x","article-title":"Radiation damage to the lung: mitigation by angiotensin-converting enzyme (ACE) inhibitors","volume":"17","author":"Medhora","year":"2012","journal-title":"Respirology."},{"key":"S1935789323002264_ref49","unstructured":"49. Food and Drug Administration (FDA), Center for Drug Evaluation and Research (CDER), Center for Biologics Evaluation and Research (CBER), Product Development Under the Animal Rule. Guidance for Industry; 2015."},{"key":"S1935789323002264_ref7","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1093\/toxsci\/kfx151","article-title":"Editor\u2019s highlight: pulmonary vascular thrombosis in rats exposed to inhaled sulfur mustard","volume":"159","author":"McGraw","year":"2017","journal-title":"Toxicol Sci."},{"key":"S1935789323002264_ref58","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1667\/RADE-20-00259.1","article-title":"Establishing pediatric mouse models of the hematopoietic acute radiation syndrome and the delayed effects of acute radiation exposure","volume":"195","author":"Patterson","year":"2021","journal-title":"Radiat Res."},{"key":"S1935789323002264_ref26","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.toxlet.2018.12.006","article-title":"Victims of chemical terrorism, a family of four who were exposed to sulfur mustard","volume":"303","author":"Sezigen","year":"2019","journal-title":"Toxicol Lett."},{"key":"S1935789323002264_ref31","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.freeradbiomed.2020.09.020","article-title":"N-Acetylcysteine as a treatment for sulphur mustard poisoning","volume":"161","author":"Sawyer","year":"2020","journal-title":"Free Radic Biol Med."},{"key":"S1935789323002264_ref74","unstructured":"74. Institute of Medicine. Drug repurposing and repositioning: workshop summary; The National Academies Collection: roundtable on translating genomic-based research for health; 2014."},{"key":"S1935789323002264_ref3","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1667\/RR15137.1","article-title":"Challenges and benefits of repurposing products for use during a radiation public health emergency: lessons learned from biological threats and other disease treatments","volume":"190","author":"DiCarlo","year":"2018","journal-title":"Radiat Res."},{"key":"S1935789323002264_ref21","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1258\/acb.2012.012040","article-title":"A randomized controlled trial on the anti-inflammatory effects of curcumin in patients with chronic sulphur mustard-induced cutaneous complications","volume":"49","author":"Panahi","year":"2012","journal-title":"Ann Clin Biochem."},{"key":"S1935789323002264_ref24","first-page":"86","article-title":"Topical use of N-acetylcysteine for reduction of skin reaction to radiation therapy","volume":"10","author":"Kim","year":"1983","journal-title":"Semin Oncol."},{"key":"S1935789323002264_ref47","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1002\/ddr.21163","article-title":"Building the strategic national stockpile through the NIAID Radiation Nuclear Countermeasures Program","volume":"75","author":"Rios","year":"2014","journal-title":"Drug Dev Res."},{"key":"S1935789323002264_ref34","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1080\/08958370490442520","article-title":"Asthmalike symptoms following intratracheal exposure of guinea pigs to sulfur mustard aerosol: therapeutic efficacy of exogenous lung surfactant curosurf and salbutamol","volume":"16","author":"van Helden","year":"2004","journal-title":"Inhal Toxicol."},{"key":"S1935789323002264_ref59","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1097\/HP.0b013e3182667309","article-title":"Establishing a murine model of the hematopoietic syndrome of the acute radiation syndrome","volume":"103","author":"Plett","year":"2012","journal-title":"Health Phys."},{"key":"S1935789323002264_ref72","unstructured":"72. Shea-Donohue, T , Fasano, A , Zhao, A , et al. An acute radiation syndrome (ARS) nonhuman primate (NHP) research platform: prolonged gastrointestinal (GI) dysfunction observed in NHPs surviving the acute heme and GI syndromes. Presented at the Fifty-fifth Annual Meeting of the Radiation Research Society; 2009."},{"key":"S1935789323002264_ref33","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1667\/RR14686.1","article-title":"Radiation mitigating properties of intranasally administered KL4 surfactant in a murine model of radiation-induced lung damage","volume":"188","author":"Christofidou-Solomidou","year":"2017","journal-title":"Radiat Res."},{"key":"S1935789323002264_ref25","doi-asserted-by":"crossref","first-page":"52","DOI":"10.7205\/MILMED.170.1.52","article-title":"N-acetyl-L-cysteine as prophylaxis against sulfur mustard","volume":"170","author":"Bobb","year":"2005","journal-title":"Mil Med."},{"key":"S1935789323002264_ref70","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.toxlet.2019.10.017","article-title":"Myelosuppression and acute hematological complications of sulfur mustard exposure in victims of chemical terrorism","volume":"318","author":"Sezigen","year":"2020","journal-title":"Toxicol Lett."},{"key":"S1935789323002264_ref32","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1111\/1759-7714.12938","article-title":"Efficacy of nebulized acetylcysteine for relieving symptoms and reducing usage of expectorants in patients with radiation pneumonitis","volume":"10","author":"Han","year":"2019","journal-title":"Thorac Cancer."},{"key":"S1935789323002264_ref13","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1097\/HP.0b013e3181c21273","article-title":"Biomimetic actinide chelators: an update on the preclinical development of the orally active hydroxypyridonate decorporation agents 3,4,3-LI(1,2-HOPO) and 5-LIO(Me-3,2-HOPO)","volume":"99","author":"Abergel","year":"2010","journal-title":"Health Phys."},{"key":"S1935789323002264_ref57","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1097\/HP.0000000000001352","article-title":"Immune reconstitution and thymic involution in the acute and delayed hematopoietic radiation syndromes","volume":"119","author":"Wu","year":"2020","journal-title":"Health Phys."},{"key":"S1935789323002264_ref5","doi-asserted-by":"crossref","first-page":"15330338211039681","DOI":"10.1177\/15330338211039681","article-title":"Review of the terminology describing ionizing radiation-induced skin injury: a case for standardization","volume":"20","author":"Burnett","year":"2021","journal-title":"Technol Cancer Res Treat."},{"key":"S1935789323002264_ref9","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1001\/dmp.2012.46a","article-title":"User-managed inventory: an approach to forward-deployment of urgently needed medical countermeasures for mass-casualty and terrorism incidents","volume":"6","author":"Coleman","year":"2012","journal-title":"Disaster Med Public Health Prep."},{"key":"S1935789323002264_ref28","doi-asserted-by":"crossref","first-page":"57","DOI":"10.2174\/1871523017666180411162114","article-title":"Randomized double-blind placebo-controlled trial of celecoxib for the prevention of skin toxicity in patients receiving radiation therapy for Breast cancer","volume":"17","author":"Ghasemi","year":"2018","journal-title":"Antiinflamm Antiallergy Agents Med Chem."},{"key":"S1935789323002264_ref62","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1097\/HP.0000000000000961","article-title":"Effect of sex on biomarker response in a mouse model of the hematopoietic acute radiation syndrome","volume":"116","author":"Jones","year":"2019","journal-title":"Health Phys."},{"key":"S1935789323002264_ref14","doi-asserted-by":"crossref","first-page":"448","DOI":"10.7205\/MILMED.171.5.448","article-title":"Sulfur mustard-induced neutropenia: treatment with granulocyte colony-stimulating factor","volume":"171","author":"Anderson","year":"2006","journal-title":"Mil Med."},{"key":"S1935789323002264_ref69","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.3390\/pathogens10111497","article-title":"Beyond the list: bioagent-agnostic signatures could enable a more flexible and resilient biodefense posture than an approach based on priority agent lists alone","volume":"10","author":"Leiser","year":"2021","journal-title":"Pathogens."},{"key":"S1935789323002264_ref67","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1667\/RR14283.1","article-title":"Biomolecular analysis of beta dose-dependent cutaneous radiation injury in a porcine model","volume":"192","author":"Burnett","year":"2019","journal-title":"Radiat Res."},{"key":"S1935789323002264_ref55","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1097\/HP.0000000000001314","article-title":"A potential role for excess tissue iron in development of cardiovascular delayed effects of acute radiation exposure","volume":"119","author":"Miller","year":"2020","journal-title":"Health Phys."},{"key":"S1935789323002264_ref4","doi-asserted-by":"crossref","unstructured":"4. Rios, CI , Cassatt, DR , Hollingsworth, BA , et al. Commonalities between COVID-19 and radiation injury. Radiat Res. Published online October 2020. doi: 10.1667\/RADE-20-00188.1","DOI":"10.1667\/RADE-20-00188.1"},{"key":"S1935789323002264_ref40","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.ijrobp.2022.01.023","article-title":"Pharmacologic ACE-inhibition mitigates radiation-induced pneumonitis by suppressing ACE-expressing lung myeloid cells","volume":"113","author":"Sharma","year":"2022","journal-title":"Int J Radiat Oncol Biol Phys."},{"key":"S1935789323002264_ref44","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.pupt.2010.09.004","article-title":"Sulfur mustard-induced pulmonary injury: therapeutic approaches to mitigating toxicity","volume":"24","author":"Weinberger","year":"2011","journal-title":"Pulm Pharmacol Ther."},{"key":"S1935789323002264_ref10","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1002\/ddr.21165","article-title":"Evaluating the toxicity of novel Zn-DTPA tablet formulation in dogs and rats","volume":"75","author":"Shankar","year":"2014","journal-title":"Drug Dev Res."},{"key":"S1935789323002264_ref17","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1016\/j.intimp.2009.08.023","article-title":"Serum levels of GM-CSF 20 years after sulfur mustard exposure: Sardasht-Iran Cohort Study","volume":"9","author":"Amiri","year":"2009","journal-title":"Int Immunopharmacol."},{"key":"S1935789323002264_ref18","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.taap.2018.06.008","article-title":"Expression of cytokines and chemokines in mouse skin treated with sulfur mustard","volume":"355","author":"Chang","year":"2018","journal-title":"Toxicol Appl Pharmacol."},{"key":"S1935789323002264_ref16","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1089\/jam.2007.0590","article-title":"Increased granulocyte-colony stimulating factor (G-CSF) and granulocyte-macrophage colony stimulating factor (GM-CSF) levels in BAL fluid from patients with sulfur mustard gas-induced pulmonary fibrosis","volume":"20","author":"Emad","year":"2007","journal-title":"J Aerosol Med."},{"key":"S1935789323002264_ref43","first-page":"415","article-title":"A trans-agency workshop on the pathophysiology of radiation-induced lung injury","volume":"197","author":"Cassatt","year":"2022","journal-title":"Radiat Res."},{"key":"S1935789323002264_ref60","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1097\/HP.0000000000000354","article-title":"The H-ARS dose response relationship (DRR): validation and variables","volume":"109","author":"Plett","year":"2015","journal-title":"Health Phys."},{"key":"S1935789323002264_ref27","doi-asserted-by":"crossref","first-page":"S114","DOI":"10.1097\/01.COC.0000074149.95710.40","article-title":"Celecoxib reduces skin damage after radiation: selective reduction of chemokine and receptor mRNA expression in irradiated skin but not in irradiated mammary tumor","volume":"26","author":"Liang","year":"2003","journal-title":"Am J Clin Oncol."},{"key":"S1935789323002264_ref23","first-page":"577","article-title":"The preventive effect of N-acetylcysteine on radiation-induced dermatitis in a rat model","volume":"15","author":"Demirel","year":"2010","journal-title":"J BUON."},{"key":"S1935789323002264_ref20","doi-asserted-by":"crossref","first-page":"3159","DOI":"10.2147\/DDDT.S265228","article-title":"Curcumin protects against radiotherapy-induced oxidative injury to the skin","volume":"14","author":"Shabeeb","year":"2020","journal-title":"Drug Des Devel Ther."},{"key":"S1935789323002264_ref61","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1667\/RR14724.1","article-title":"Characterization and etiology of swollen muzzles in irradiated mice","volume":"191","author":"Garrett","year":"2019","journal-title":"Radiat Res."},{"key":"S1935789323002264_ref48","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1097\/HP.0000000000000279","article-title":"Medical countermeasures for radiation exposure and related injuries: characterization of medicines, FDA-approval status and inclusion into the Strategic National Stockpile","volume":"108","author":"Singh","year":"2015","journal-title":"Health Phys."},{"key":"S1935789323002264_ref15","first-page":"649","article-title":"Therapeutic effects of rhEPO, rhG-CSF on sulfur mustard induced toxicity in dogs","volume":"33","author":"Cai","year":"2004","journal-title":"Wei Sheng Yan Jiu."},{"key":"S1935789323002264_ref46","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1088\/1361-6498\/ac0d3f","article-title":"United States medical preparedness for nuclear and radiological emergencies","volume":"41","author":"DiCarlo","year":"2021","journal-title":"J Radiol Prot."},{"key":"S1935789323002264_ref42","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1667\/RADE-20-00120.1","article-title":"Cutaneous radiation injuries: models, assessment and treatments","volume":"194","author":"DiCarlo","year":"2020","journal-title":"Radiat Res."},{"key":"S1935789323002264_ref11","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1208\/s12248-016-9916-z","article-title":"Synthesis and physicochemical characterization of a diethyl ester prodrug of DTPA and its investigation as an oral decorporation agent in rats","volume":"18","author":"Huckle","year":"2016","journal-title":"AAPS J."},{"key":"S1935789323002264_ref8","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1197\/j.aem.2006.03.567","article-title":"Equipment, supplies, and pharmaceuticals: how much might it cost to achieve basic surge capacity?","volume":"13","author":"Hanfling","year":"2006","journal-title":"Acad Emerg Med."},{"key":"S1935789323002264_ref63","doi-asserted-by":"crossref","unstructured":"63. Patterson, AM , Vemula, S , Plett, PA , et al. Age and sex divergence in hematopoietic radiosensitivity in aged mouse models of the hematopoietic acute radiation syndrome. Radiat Res. 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