{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T19:51:42Z","timestamp":1774122702507,"version":"3.50.1"},"reference-count":28,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T00:00:00Z","timestamp":1750377600000},"content-version":"unspecified","delay-in-days":170,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Disaster med. public health prep."],"published-print":{"date-parts":[[2025]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t  <jats:sec id=\"S1935789325100918_sec1\">\n\t    <jats:title>Objectives<\/jats:title>\n\t    <jats:p>To describe the process of the development of evidence-based guidelines on the assessment and clinical management of internal contamination with transuranic actinides (specifically plutonium, americium, and curium) in incidents where workers, emergency responders, and the public might uptake these radionuclides internally through inhalation, ingestion, or wound contamination.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S1935789325100918_sec2\" sec-type=\"methods\">\n\t    <jats:title>Methods<\/jats:title>\n\t    <jats:p>The World Health Organization (WHO) set up a guidelines development group (GDG) that follows the protocol required for producing evidence-based recommendations as described elsewhere. The GRADE\u00ae approach was applied throughout the process, including developing research questions formulation, prioritization and rating the importance for the outcomes, assessing the certainty of the evidence, considering contextual factors, and making recommendations.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S1935789325100918_sec3\" sec-type=\"results\">\n\t    <jats:title>Results<\/jats:title>\n\t    <jats:p>Through 3 working group meetings held 2023-2024, the GDG defined and rated patient-important health outcomes, and evidence gathered through systematic reviews and its certainty rating, working towards formulating the recommendations using an evidence-to-recommendation (EtR) framework.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S1935789325100918_sec4\" sec-type=\"conclusions\">\n\t    <jats:title>Conclusions<\/jats:title>\n\t    <jats:p>The WHO protocol for developing health care management guidelines uses a transparent and robust evidence-based GRADE\u00ae approach. Once published, these guidelines will provide the first evidence-based recommendations for assessment and clinical management of internal contamination with transuranic actinides.<\/jats:p>\n\t  <\/jats:sec>","DOI":"10.1017\/dmp.2025.10091","type":"journal-article","created":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T05:28:13Z","timestamp":1750397293000},"source":"Crossref","is-referenced-by-count":3,"title":["Development of Evidence-based Guidelines on Assessment and Management of Internal Contamination with Transuranic Actinides"],"prefix":"10.1017","volume":"19","author":[{"given":"Chunsheng","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhanat","family":"Kenbayeva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas","family":"Dainiak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9912-0031","authenticated-orcid":false,"given":"Juan Jos\u00e9","family":"Yepes-Nu\u00f1ez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7509-242X","authenticated-orcid":false,"given":"Hajo","family":"Zeeb","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-5946-1563","authenticated-orcid":false,"given":"Sehajpreet","family":"Gill","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makoto","family":"Akashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arlene","family":"Alves","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6206-9191","authenticated-orcid":false,"given":"Arthur","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8113-0015","authenticated-orcid":false,"given":"Andrea","family":"DiCarlo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7777-3760","authenticated-orcid":false,"given":"Carol","family":"Iddins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ziad","family":"Kazzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Klumpp","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kurihara","family":"Osamu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4565-8485","authenticated-orcid":false,"given":"Maria Antonia","family":"Lopez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guillaume","family":"Phan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"Port","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony","family":"Riddell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adela","family":"Salame-Alfie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pramilla","family":"Sawant","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideo","family":"Tatsuzaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valentina","family":"Vassilenko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2025,6,20]]},"reference":[{"key":"S1935789325100918_r10","unstructured":"10. World Health Organization (WHO). Public notice for comments on WHO Guideline on Internal Contamination Assessment and Management: Transuranium Radionuclides. December 24, 2024. https:\/\/www.who.int\/news-room\/articles-detail\/public-notice-for-comments-on-who-guideline-on-internal-contamination-assessment-and-management--transuranium-radionuclides"},{"key":"S1935789325100918_r24","doi-asserted-by":"publisher","DOI":"10.1097\/00004032-197409000-00007"},{"key":"S1935789325100918_r28","doi-asserted-by":"publisher","DOI":"10.1097\/HP.0000000000000821"},{"key":"S1935789325100918_r4","doi-asserted-by":"publisher","DOI":"10.1093\/rpd\/ncm354"},{"key":"S1935789325100918_r3","doi-asserted-by":"publisher","DOI":"10.1177\/01466453211028020"},{"key":"S1935789325100918_r2","doi-asserted-by":"publisher","DOI":"10.1097\/HP.0000000000001250"},{"key":"S1935789325100918_r19","unstructured":"19. Gill, S , Dreger, S , Zeeb, H , et al. 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Office of Health Assessment and Translation (OHAT), Division of the National Toxicology Program, National Institute of Environmental Health Sciences; March 4, 2019."},{"key":"S1935789325100918_r17","volume-title":"Cochrane Handbook for Systematic Reviews of Interventions version 6.5","author":"McKenzie","year":"2024"},{"key":"S1935789325100918_r21","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.i2016"},{"key":"S1935789325100918_r22","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.i2089"},{"key":"S1935789325100918_r23","doi-asserted-by":"publisher","DOI":"10.1097\/HP.0000000000001131"}],"container-title":["Disaster Medicine and Public Health Preparedness"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S1935789325100918","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T05:28:17Z","timestamp":1750397297000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S1935789325100918\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":28,"alternative-id":["S1935789325100918"],"URL":"https:\/\/doi.org\/10.1017\/dmp.2025.10091","relation":{},"ISSN":["1935-7893","1938-744X"],"issn-type":[{"value":"1935-7893","type":"print"},{"value":"1938-744X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]},"article-number":"e156"}}