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Central to this success was the introduction of drugs that suppress the immune system and prevent rejection. The most commonly used class of immunosuppressing drugs are calcineurin inhibitors (CNIs). Calcineurin is a ubiquitous enzyme that is important for T-cell function. With more people taking CNIs for longer and longer periods of time the consequences of calcineurin inhibition on other organ systems \u2013 particularly the kidney \u2013 have become a growing concern. Virtually all people who take a CNI will develop some degree of kidney toxicity and up to 10% will progress to kidney failure. In the past 15 years, research into calcineurin action has identified distinct actions of the two main isoforms of the catalytic subunit of the enzyme. The \u03b1-isoform is required for kidney function whereas the \u03b2-isoform has a predominant role in the immune system. This review will discuss the current state of knowledge about calcineurin isoforms and how these new insights may reshape post-transplant immunosuppression.<\/jats:p>","DOI":"10.1017\/erm.2012.8","type":"journal-article","created":{"date-parts":[[2012,7,4]],"date-time":"2012-07-04T23:07:01Z","timestamp":1341443221000},"source":"Crossref","is-referenced-by-count":36,"title":["Calcineurin inhibitors and immunosuppression \u2013 a tale of two isoforms"],"prefix":"10.1017","volume":"14","author":[{"given":"Clintoria R.","family":"Williams","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer L.","family":"Gooch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2012,7,4]]},"reference":[{"key":"S1462399412000087_ref42","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.8.4650"},{"key":"S1462399412000087_ref33","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.106.5.1625"},{"key":"S1462399412000087_ref17","doi-asserted-by":"publisher","DOI":"10.1016\/S0898-6568(98)00019-9"},{"key":"S1462399412000087_ref60","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2009.222"},{"key":"S1462399412000087_ref66","volume-title":"Surgery of the Soul","author":"Murray","year":"2004"},{"key":"S1462399412000087_ref48","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.072647999"},{"key":"S1462399412000087_ref35","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830221008"},{"key":"S1462399412000087_ref6","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1968.03150110037006"},{"key":"S1462399412000087_ref23","unstructured":"23 Cecka J.M. 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