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We focus on HLA (human leukocyte antigen)-DQ (DQ) alleles associated with celiac disease (CD) and type 1 diabetes (T1D) and the role of the murine DQ-like allele, H2-A<jats:sup>g7<\/jats:sup>(I-A<jats:sup>g7<\/jats:sup>or A<jats:sup>g7<\/jats:sup>), in murine T1D. MHCII molecules bind peptides, and alleles vary in their peptide-binding specificity. Disease-associated alleles permit binding of disease-inducing peptides, such as gluten-derived, Glu-\/Pro-rich gliadin peptides in CD and peptides from islet autoantigens, including insulin, in T1D. In addition, the CD-associated DQ2.5 and DQ8 alleles are unusual in their interactions with factors that regulate their peptide loading, invariant chain (Ii) and HLA-DM (DM). The same alleles, as well as other T1D DQ risk alleles (and A<jats:sup>g7<\/jats:sup>), share nonpolar residues in place of Asp at \u03b257 and prefer peptides that place acidic side chains in a pocket in the MHCII groove (P9). Antigen-presenting cells from T1D-susceptible mice and humans retain CLIP because of poor DM editing, although underlying mechanisms differ between species. We propose that these effects on peptide presentation make key contributions to CD and T1D pathogenesis.<\/jats:p>","DOI":"10.1017\/erm.2012.9","type":"journal-article","created":{"date-parts":[[2012,7,6]],"date-time":"2012-07-06T11:17:56Z","timestamp":1341573476000},"source":"Crossref","is-referenced-by-count":48,"title":["On the perils of poor editing: regulation of peptide loading by HLA-DQ and H2-A molecules associated with celiac disease and type 1 diabetes"],"prefix":"10.1017","volume":"14","author":[{"given":"Robert","family":"Busch","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"De Riva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas V.","family":"Hadjinicolaou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tieying","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth D.","family":"Mellins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2012,7,6]]},"reference":[{"key":"S1462399412000099_ref156","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.181342398"},{"key":"S1462399412000099_ref158","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkh381"},{"key":"S1462399412000099_ref151","doi-asserted-by":"publisher","DOI":"10.1016\/S0198-8859(99)00126-3"},{"key":"S1462399412000099_ref155","unstructured":"155 Schrodinger L. 2010. 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