{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T02:42:32Z","timestamp":1790649752127,"version":"4.1.0"},"reference-count":150,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2019,11,26]],"date-time":"2019-11-26T00:00:00Z","timestamp":1574726400000},"content-version":"unspecified","delay-in-days":329,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Expert Rev. Mol. Med."],"published-print":{"date-parts":[[2019]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Autosomal dominant polycystic kidney disease (ADPKD) is the most common monogenic kidney disease and is caused by heterozygous germ-line mutations in either<jats:italic>PKD1<\/jats:italic>(85%) or<jats:italic>PKD2<\/jats:italic>(15%). It is characterised by the formation of numerous fluid-filled renal cysts and leads to adult-onset kidney failure in ~50% of patients by 60 years. Kidney cysts in ADPKD are focal and sporadic, arising from the clonal proliferation of collecting-duct principal cells, but in only 1\u20132% of nephrons for reasons that are not clear. Previous studies have demonstrated that further postnatal reductions in<jats:italic>PKD1<\/jats:italic>(or<jats:italic>PKD2<\/jats:italic>) dose are required for kidney cyst formation, but the exact triggering factors are not clear. A growing body of evidence suggests that DNA damage, and activation of the DNA damage response pathway, are altered in ciliopathies. The aims of this review are to: (i) analyse the evidence linking DNA damage and renal cyst formation in ADPKD; (ii) evaluate the advantages and disadvantages of biomarkers to assess DNA damage in ADPKD and finally, (iii) evaluate the potential effects of current clinical treatments on modifying DNA damage in ADPKD. These studies will address the significance of DNA damage and may lead to a new therapeutic approach in ADPKD.<\/jats:p>","DOI":"10.1017\/erm.2019.6","type":"journal-article","created":{"date-parts":[[2019,11,26]],"date-time":"2019-11-26T08:35:58Z","timestamp":1574757358000},"source":"Crossref","is-referenced-by-count":12,"title":["The role of DNA damage as a therapeutic target in autosomal dominant polycystic kidney disease"],"prefix":"10.1017","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3269-3801","authenticated-orcid":false,"given":"Jennifer Q. J.","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sayanthooran","family":"Saravanabavan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Munt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annette T. Y.","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David C.","family":"Harris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter C.","family":"Harris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiping","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gopala K.","family":"Rangan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2019,11,26]]},"reference":[{"key":"S1462399419000061_ref146","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbior.2014.11.001"},{"key":"S1462399419000061_ref145","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1016\/S0022-2275(20)39163-X","article-title":"Role of lactosylceramide and MAP kinase in the proliferation of proximal tubular cells in human polycystic kidney disease","volume":"37","author":"Chatterjee","year":"1996","journal-title":"Journal of Lipid Research"},{"key":"S1462399419000061_ref144","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1016\/S0022-2275(20)41159-9","article-title":"Abnormalities of glycosphingolipid, sulfatide, and ceramide in the polycystic (cpk\/cpk) mouse","volume":"35","author":"Deshmukh","year":"1994","journal-title":"Journal of Lipid Research"},{"key":"S1462399419000061_ref143","doi-asserted-by":"publisher","DOI":"10.1016\/j.semnephrol.2018.01.007"},{"key":"S1462399419000061_ref141","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-009-9936-5"},{"key":"S1462399419000061_ref139","doi-asserted-by":"publisher","DOI":"10.1038\/nature19329"},{"key":"S1462399419000061_ref138","doi-asserted-by":"publisher","DOI":"10.1023\/A:1026084420943"},{"key":"S1462399419000061_ref134","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00551.2015"},{"key":"S1462399419000061_ref132","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2016.07.023"},{"key":"S1462399419000061_ref131","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2016.10.018"},{"key":"S1462399419000061_ref128","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-16436-9"},{"key":"S1462399419000061_ref137","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkm860"},{"key":"S1462399419000061_ref127","first-page":"3867","article-title":"Curcumin triggers DNA damage and inhibits expression of DNA repair proteins in human lung cancer cells","volume":"35","author":"Ting","year":"2015","journal-title":"Anticancer Research"},{"key":"S1462399419000061_ref126","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfj153"},{"key":"S1462399419000061_ref125","doi-asserted-by":"publisher","DOI":"10.3892\/or.2016.5002"},{"key":"S1462399419000061_ref124","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00419.2010"},{"key":"S1462399419000061_ref123","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1506197"},{"key":"S1462399419000061_ref122","doi-asserted-by":"publisher","DOI":"10.4061\/2010\/157591"},{"key":"S1462399419000061_ref121","doi-asserted-by":"publisher","DOI":"10.1172\/JCI64401"},{"key":"S1462399419000061_ref120","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrgentox.2018.01.007"},{"key":"S1462399419000061_ref119","doi-asserted-by":"publisher","DOI":"10.1210\/en.2015-1572"},{"key":"S1462399419000061_ref116","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-07-2310"},{"key":"S1462399419000061_ref135","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2017070819"},{"key":"S1462399419000061_ref112","doi-asserted-by":"publisher","DOI":"10.1080\/10715762.2016.1204651"},{"key":"S1462399419000061_ref110","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1011498108"},{"key":"S1462399419000061_ref109","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2014.24"},{"key":"S1462399419000061_ref108","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2016.11.043"},{"key":"S1462399419000061_ref111","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-07300-x"},{"key":"S1462399419000061_ref107","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2015.04.006"},{"key":"S1462399419000061_ref106","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2017.12.002"},{"key":"S1462399419000061_ref117","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-06-4447"},{"key":"S1462399419000061_ref105","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.06300615"},{"key":"S1462399419000061_ref104","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfx079"},{"key":"S1462399419000061_ref103","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0115715"},{"key":"S1462399419000061_ref102","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1402685"},{"key":"S1462399419000061_ref101","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2017.6002"},{"key":"S1462399419000061_ref100","first-page":"733","article-title":"Immunological methods for detection of carcinogen-DNA damage in humans","volume":"8","author":"Santella","year":"1999","journal-title":"Cancer Epidemiology, Biomarkers and Prevention"},{"key":"S1462399419000061_ref98","doi-asserted-by":"publisher","DOI":"10.1080\/10715760000300391"},{"key":"S1462399419000061_ref148","doi-asserted-by":"publisher","DOI":"10.1007\/s13361-016-1474-1"},{"key":"S1462399419000061_ref46","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2007101139"},{"key":"S1462399419000061_ref44","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1681\/ASN.V1071524","article-title":"Somatic PKD2 mutations in individual kidney and liver cysts support a \u2018two-hit\u2019 model of cystogenesis in type 2 autosomal dominant polycystic kidney disease","volume":"10","author":"Pei","year":"1999","journal-title":"Journal of the American Society of Nephrology"},{"key":"S1462399419000061_ref42","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81570-6"},{"key":"S1462399419000061_ref77","doi-asserted-by":"publisher","DOI":"10.1038\/srep15238"},{"key":"S1462399419000061_ref41","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119147"},{"key":"S1462399419000061_ref47","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2017080878"},{"key":"S1462399419000061_ref150","first-page":"39","article-title":"Systems biology of polycystic kidney disease: a critical review","volume":"7","author":"Menezes","year":"2015","journal-title":"Wiley Interdisciplinary Reviews: Systems Biology and Medicine"},{"key":"S1462399419000061_ref39","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2010030328"},{"key":"S1462399419000061_ref140","doi-asserted-by":"publisher","DOI":"10.1159\/000488807"},{"key":"S1462399419000061_ref58","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2006020136"},{"key":"S1462399419000061_ref37","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.00330705"},{"key":"S1462399419000061_ref32","doi-asserted-by":"publisher","DOI":"10.1016\/S0011-5029(05)80007-0"},{"key":"S1462399419000061_ref67","doi-asserted-by":"publisher","DOI":"10.1177\/0300060513475956"},{"key":"S1462399419000061_ref76","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-013-1378-0"},{"key":"S1462399419000061_ref31","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1797.2003.00163.x"},{"key":"S1462399419000061_ref15","doi-asserted-by":"publisher","DOI":"10.1007\/s12038-012-9218-2"},{"key":"S1462399419000061_ref30","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/301982"},{"key":"S1462399419000061_ref29","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1797.2012.01572.x"},{"key":"S1462399419000061_ref43","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(00)80135-5"},{"key":"S1462399419000061_ref26","doi-asserted-by":"publisher","DOI":"10.1093\/mutage\/geq047"},{"key":"S1462399419000061_ref25","doi-asserted-by":"publisher","DOI":"10.1002\/em.21694"},{"key":"S1462399419000061_ref24","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(88)90075-1"},{"key":"S1462399419000061_ref40","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81793-6"},{"key":"S1462399419000061_ref9","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp0804458"},{"key":"S1462399419000061_ref23","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2008090998"},{"key":"S1462399419000061_ref87","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2009.090227"},{"key":"S1462399419000061_ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.semnephrol.2015.10.002"},{"key":"S1462399419000061_ref75","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.2215\/CJN.05850518","article-title":"Vascular dysfunction, oxidative stress, and inflammation in autosomal dominant polycystic kidney disease","volume":"13","author":"Nowak","year":"2018","journal-title":"Clinical Journal of the American Society of Nephrology"},{"key":"S1462399419000061_ref95","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrrev.2015.07.001"},{"key":"S1462399419000061_ref36","doi-asserted-by":"publisher","DOI":"10.1172\/JCI64313"},{"key":"S1462399419000061_ref18","doi-asserted-by":"publisher","DOI":"10.1093\/mutage\/geh025"},{"key":"S1462399419000061_ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2017.06.059"},{"key":"S1462399419000061_ref147","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1207087"},{"key":"S1462399419000061_ref34","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2006.050342"},{"key":"S1462399419000061_ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.gde.2003.11.001"},{"key":"S1462399419000061_ref115","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-06-1500"},{"key":"S1462399419000061_ref10","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.10360818"},{"key":"S1462399419000061_ref12","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0804615"},{"key":"S1462399419000061_ref35","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2008.686"},{"key":"S1462399419000061_ref1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)60907-2"},{"key":"S1462399419000061_ref99","doi-asserted-by":"publisher","DOI":"10.1007\/s00420-006-0106-7"},{"key":"S1462399419000061_ref73","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2014.02.003"},{"key":"S1462399419000061_ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2016.05.004"},{"key":"S1462399419000061_ref61","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2013050565"},{"key":"S1462399419000061_ref28","first-page":"303","article-title":"Impaired DNA repair in patients with end-stage renal disease and its improvement with hemodialysis","volume":"17","author":"Zevin","year":"1991","journal-title":"Mineral and Electrolyte Metabolism"},{"key":"S1462399419000061_ref85","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e32835ba77e"},{"key":"S1462399419000061_ref13","doi-asserted-by":"publisher","DOI":"10.1038\/nature08467"},{"key":"S1462399419000061_ref11","doi-asserted-by":"publisher","DOI":"10.1101\/sqb.2000.65.127"},{"key":"S1462399419000061_ref130","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.03250410"},{"key":"S1462399419000061_ref80","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2014.10.001"},{"key":"S1462399419000061_ref2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2018050493"},{"key":"S1462399419000061_ref16","doi-asserted-by":"publisher","DOI":"10.1038\/362709a0"},{"key":"S1462399419000061_ref70","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(16)30529-0"},{"key":"S1462399419000061_ref8","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1987.121"},{"key":"S1462399419000061_ref68","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddn180"},{"key":"S1462399419000061_ref52","first-page":"366","article-title":"Ciliopathies and DNA damage: an emerging nexus","volume":"24","author":"Attanasio","year":"2015","journal-title":"Current Opinion in Nephrology and Hypertension"},{"key":"S1462399419000061_ref56","doi-asserted-by":"publisher","DOI":"10.1038\/ncpneph0070"},{"key":"S1462399419000061_ref96","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.078436"},{"key":"S1462399419000061_ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2015.10.040"},{"key":"S1462399419000061_ref21","doi-asserted-by":"publisher","DOI":"10.1038\/nature10760"},{"key":"S1462399419000061_ref3","doi-asserted-by":"publisher","DOI":"10.1111\/imj.13143"},{"key":"S1462399419000061_ref88","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddp190"},{"key":"S1462399419000061_ref149","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemphyslip.2015.08.014"},{"key":"S1462399419000061_ref48","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddp147"},{"key":"S1462399419000061_ref49","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2013080864"},{"key":"S1462399419000061_ref142","doi-asserted-by":"publisher","DOI":"10.1159\/000444926"},{"key":"S1462399419000061_ref60","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2013.08.006"},{"key":"S1462399419000061_ref14","first-page":"305","article-title":"\u03b3-H2AX- A novel biomaker for DNA double-strand breaks","volume":"22","author":"Kuo","year":"2008","journal-title":"In Vivo"},{"key":"S1462399419000061_ref50","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00470.2018"},{"key":"S1462399419000061_ref129","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2171"},{"key":"S1462399419000061_ref22","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.28144"},{"key":"S1462399419000061_ref51","doi-asserted-by":"publisher","DOI":"10.1186\/s13630-016-0040-6"},{"key":"S1462399419000061_ref27","first-page":"3468","article-title":"Impairment of DNA repair in the course of long-term hemodialysis and under cyclosporine immunosuppression after renal transplantation","volume":"28","author":"Vamvakas","year":"1996","journal-title":"Transplantation Proceedings"},{"key":"S1462399419000061_ref83","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00458.2006"},{"key":"S1462399419000061_ref33","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddh336"},{"key":"S1462399419000061_ref86","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2014.04.002"},{"key":"S1462399419000061_ref55","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1004594"},{"key":"S1462399419000061_ref57","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0308463100"},{"key":"S1462399419000061_ref59","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2006090985"},{"key":"S1462399419000061_ref63","doi-asserted-by":"publisher","DOI":"10.5527\/wjn.v5.i4.339"},{"key":"S1462399419000061_ref64","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2014.09.019"},{"key":"S1462399419000061_ref38","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.05651207"},{"key":"S1462399419000061_ref19","doi-asserted-by":"publisher","DOI":"10.1097\/WOX.0b013e3182439613"},{"key":"S1462399419000061_ref66","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2018040442"},{"key":"S1462399419000061_ref113","doi-asserted-by":"publisher","DOI":"10.1590\/S1415-47572011005000060"},{"key":"S1462399419000061_ref65","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.402503"},{"key":"S1462399419000061_ref114","doi-asserted-by":"publisher","DOI":"10.1158\/1940-6207.CAPR-10-0157"},{"key":"S1462399419000061_ref78","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-14083-8"},{"key":"S1462399419000061_ref71","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(16)30307-2"},{"key":"S1462399419000061_ref92","first-page":"613","volume-title":"DNA Repair Protocols. Methods in Molecular Biology (Methods and Protocols)","volume":"920","author":"Sharma","year":"2012"},{"key":"S1462399419000061_ref133","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2015020132"},{"key":"S1462399419000061_ref62","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2018050518"},{"key":"S1462399419000061_ref72","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2013101122"},{"key":"S1462399419000061_ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2018.03.013"},{"key":"S1462399419000061_ref53","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2015.03.005"},{"key":"S1462399419000061_ref74","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2018.04.010"},{"key":"S1462399419000061_ref54","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.06.028"},{"key":"S1462399419000061_ref79","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2009.02.006"},{"key":"S1462399419000061_ref136","doi-asserted-by":"publisher","DOI":"10.1016\/0921-8734(93)90023-V"},{"key":"S1462399419000061_ref118","doi-asserted-by":"publisher","DOI":"10.1158\/1940-6207.CAPR-08-0081"},{"key":"S1462399419000061_ref82","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00060.2003"},{"key":"S1462399419000061_ref97","doi-asserted-by":"publisher","DOI":"10.1080\/10590500902885684"},{"key":"S1462399419000061_ref45","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/8.3.509"},{"key":"S1462399419000061_ref81","doi-asserted-by":"publisher","DOI":"10.1111\/nep.12045"},{"key":"S1462399419000061_ref84","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-08-1310"},{"key":"S1462399419000061_ref69","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(16)30250-9"},{"key":"S1462399419000061_ref89","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3441"},{"key":"S1462399419000061_ref91","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/3592042"},{"key":"S1462399419000061_ref90","doi-asserted-by":"publisher","DOI":"10.1385\/MB:26:3:249"},{"key":"S1462399419000061_ref93","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2523"},{"key":"S1462399419000061_ref94","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2010.6"}],"container-title":["Expert Reviews in Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S1462399419000061","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,6]],"date-time":"2022-10-06T22:53:11Z","timestamp":1665096791000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S1462399419000061\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019]]},"references-count":150,"alternative-id":["S1462399419000061"],"URL":"https:\/\/doi.org\/10.1017\/erm.2019.6","relation":{},"ISSN":["1462-3994"],"issn-type":[{"value":"1462-3994","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019]]},"article-number":"e6"}}