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The molecular mechanisms that lead to initiate CH have been of widespread concern, hence the development of the new field of research, metabolomics: one \u2018omics\u2019 approach that can reveal comprehensive information of the paradigm shift of metabolic pathways network in contrast to individual enzymatic reaction-based metabolites, have attempted and until now only 19 studies have been conducted using experimental animal and human specimens. Nuclear magnetic resonance spectroscopy and mass spectrometry-based metabolomics studies have found that CH is a metabolic disease and is mainly linked to the harmonic imbalance of glycolysis, citric acid cycle, amino acids and lipid metabolism. The current review will summarise the main outcomes of the above mentioned 19 studies that have expanded our understanding of the molecular mechanisms that may lead to CH and eventually to heart failure.<\/jats:p>","DOI":"10.1017\/erm.2021.12","type":"journal-article","created":{"date-parts":[[2021,8,11]],"date-time":"2021-08-11T06:08:31Z","timestamp":1628662111000},"source":"Crossref","is-referenced-by-count":9,"title":["Role of metabolomics in identifying cardiac hypertrophy: an overview of the past 20 years of development and future perspective"],"prefix":"10.1017","volume":"23","author":[{"given":"Sachendra Pratap","family":"Singh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rishi","family":"Sethi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shailendra Kumar","family":"Saxena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3038-9067","authenticated-orcid":false,"given":"Ashish","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2021,8,11]]},"reference":[{"key":"S1462399421000120_ref28","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.108.190918"},{"key":"S1462399421000120_ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.02.004"},{"key":"S1462399421000120_ref50","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2018.00110"},{"key":"S1462399421000120_ref19","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000057979.36322.88"},{"key":"S1462399421000120_ref20","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.24.14.6231-6240.2004"},{"key":"S1462399421000120_ref31","doi-asserted-by":"publisher","DOI":"10.1007\/s10741-020-10059-5"},{"key":"S1462399421000120_ref56","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.112.268128"},{"key":"S1462399421000120_ref1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000659"},{"key":"S1462399421000120_ref58","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.10.072"},{"key":"S1462399421000120_ref69","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.6b02930"},{"key":"S1462399421000120_ref57","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.113.000301"},{"key":"S1462399421000120_ref3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1511939"},{"key":"S1462399421000120_ref51","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.115.019351"},{"key":"S1462399421000120_ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2015.03.010"},{"key":"S1462399421000120_ref60","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-018-0800-5"},{"key":"S1462399421000120_ref42","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2011.335"},{"key":"S1462399421000120_ref66","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0134184"},{"key":"S1462399421000120_ref33","first-page":"51","volume-title":"Cellular and Molecular Pathobiology of Cardiovascular Disease","author":"William","year":"2014"},{"key":"S1462399421000120_ref40","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.117.311002"},{"key":"S1462399421000120_ref77","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jproteome.7b00595"},{"key":"S1462399421000120_ref12","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000170652.71414.16"},{"key":"S1462399421000120_ref65","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.119.013522"},{"key":"S1462399421000120_ref5","doi-asserted-by":"publisher","DOI":"10.2174\/138161206776843368"},{"key":"S1462399421000120_ref61","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jey175"},{"key":"S1462399421000120_ref64","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.118.010926"},{"key":"S1462399421000120_ref78","unstructured":"78. 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