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Methylation of HBV DNA including covalently closed circular DNA (cccDNA) is more often encountered in HCC cases than those in CHB and cirrhosis. Three typical CpG islands within the HBV genome are the common sites for methylation. The HBV cccDNA methylation affects the viral replication and protein expression in the course of infection and may associate with the disease pathogenesis and HCC development. We review the current findings in HBV DNA methylation that provide insights into its role in HCC diagnosis.<\/jats:p>","DOI":"10.1017\/erm.2022.38","type":"journal-article","created":{"date-parts":[[2022,11,16]],"date-time":"2022-11-16T05:37:35Z","timestamp":1668577055000},"update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":10,"title":["Hepatitis B virus DNA methylation and its potential role in chronic hepatitis B"],"prefix":"10.1017","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1491-2919","authenticated-orcid":false,"given":"Wei Feng","family":"Low","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun Fong","family":"Ngeow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2104-761X","authenticated-orcid":false,"given":"Jack Bee","family":"Chook","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kok Keng","family":"Tee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seng-Kai","family":"Ong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suat Cheng","family":"Peh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan Jin","family":"Bong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosmawati","family":"Mohamed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2022,11,16]]},"reference":[{"key":"S1462399422000382_ref54","doi-asserted-by":"publisher","DOI":"10.7150\/jca.26052"},{"key":"S1462399422000382_ref90","doi-asserted-by":"publisher","DOI":"10.1086\/597614"},{"key":"S1462399422000382_ref6","unstructured":"6. 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