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In this review, we summarize the main functions of ATXN3 in proteostasis, DNA repair and transcriptional regulation, as well as the emerging role in regulating chromatin structure. The mentioned molecular functions of ATXN3 are also reviewed in the context of the pathological expanded form of ATXN3.\n                  <\/jats:p>","DOI":"10.1017\/erm.2024.10","type":"journal-article","created":{"date-parts":[[2024,9,25]],"date-time":"2024-09-25T15:10:14Z","timestamp":1727277014000},"update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":22,"title":["ATXN3: a multifunctional protein involved in the polyglutamine disease spinocerebellar ataxia type 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