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The latest report suggests that down-regulation of the PD-L2\u2013RGMb pathway in the gut microbiota promotes an anti-tumour immune response, which defines a potentially effective immune strategy. However, the biological function of RGMb in a variety of human diseases has not been fully determined, and will remain an active research field. This article reviews the properties and functions of RGMb, focusing on its role under various physiological and pathological conditions.<\/jats:p>","DOI":"10.1017\/erm.2024.24","type":"journal-article","created":{"date-parts":[[2024,10,8]],"date-time":"2024-10-08T04:08:18Z","timestamp":1728360498000},"update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":11,"title":["Repulsive guidance molecules b (RGMb): molecular mechanism, function and role in diseases"],"prefix":"10.1017","volume":"26","author":[{"given":"Jie","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yijing","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zijian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shilin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haowen","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinhua","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8465-1614","authenticated-orcid":false,"given":"Renfang","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-9736-0712","authenticated-orcid":false,"given":"Xiaohong","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2024,10,8]]},"reference":[{"key":"S1462399424000243_ref52","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2008.308"},{"key":"S1462399424000243_ref80","doi-asserted-by":"publisher","DOI":"10.1016\/S1534-5807(03)00054-6"},{"key":"S1462399424000243_ref55","first-page":"1677","article-title":"Incremental 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