{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T10:55:41Z","timestamp":1790592941828,"version":"4.1.0"},"reference-count":0,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T00:00:00Z","timestamp":1757030400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Expert Rev. Mol. Med."],"published-print":{"date-parts":[[2026]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Sj\u00f6gren\u2019s syndrome (SS) is characterised by an autoimmune response that targets the salivary and lacrimal glands, resulting in dry mouth and eyes. In addition to these local manifestations, the systemic involvement of other organs can also occur. Current treatment options primarily focus on replacement therapies and the use of hormones or immunosuppressants to mitigate tissue and organ damage caused by excessive autoimmune reactions. However, these interventions are unable to restore the function of salivary glands that have sustained damage. In recent years, advancements in regenerative medicine and increasing applications of bioengineering in the medical field have highlighted the potential of salivary gland tissue engineering for treating SS. Researchers have discovered that integrating salivary gland epithelial cells with regenerative stem cells, nanozymes capable of specifically targeting and eliminating inflammation, and bioactive components into specific hydrogels or 3D scaffolds facilitates the construction of functional salivary gland organoids. Subsequently, transplanting these organoids with secretory function into the impaired salivary glands of patients aims to alleviate dry mouth symptoms caused by autoimmune damage, trauma, radiation or other factors. This review aims to provide an overview of the mechanism of salivary gland damage due to SS, along with the applications and challenges associated with salivary gland tissue engineering.<\/jats:p>","DOI":"10.1017\/erm.2025.10017","type":"journal-article","created":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T04:34:06Z","timestamp":1757046846000},"update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":1,"title":["Prospects and challenges of salivary gland tissue engineering in Sj\u00f6gren\u2019s syndrome"],"prefix":"10.1017","volume":"28","author":[{"given":"Xinying","family":"Fan","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/0265d1010","id-type":"ROR","asserted-by":"publisher"}],"name":"Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital"},{"name":"Shanxi Province Clinical Research Center for Dermatologic and Immunologic Diseases (Rheumatic Diseases)"},{"name":"Shanxi Province Clinical Theragnostic Technology Innovation Center for Immunologic and Rheumatic Diseases"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haodong","family":"Su","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/0265d1010","id-type":"ROR","asserted-by":"publisher"}],"name":"Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital"},{"name":"Shanxi Province Clinical Research Center for Dermatologic and Immunologic Diseases (Rheumatic Diseases)"},{"name":"Shanxi Province Clinical Theragnostic Technology Innovation Center for Immunologic and Rheumatic Diseases"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Tang","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/0265d1010","id-type":"ROR","asserted-by":"publisher"}],"name":"Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital"},{"name":"Shanxi Province Clinical Research Center for Dermatologic and Immunologic Diseases (Rheumatic Diseases)"},{"name":"Shanxi Province Clinical Theragnostic Technology Innovation Center for Immunologic and Rheumatic Diseases"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyao","family":"Yang","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/0265d1010","id-type":"ROR","asserted-by":"publisher"}],"name":"Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital"},{"name":"Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjin","family":"Hu","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/0265d1010","id-type":"ROR","asserted-by":"publisher"}],"name":"Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital"},{"name":"Shanxi Province Clinical Research Center for Dermatologic and Immunologic Diseases (Rheumatic Diseases)"},{"name":"Shanxi Province Clinical Theragnostic Technology Innovation Center for Immunologic and Rheumatic Diseases"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liyun","family":"Zhang","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/0265d1010","id-type":"ROR","asserted-by":"publisher"}],"name":"Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital"},{"name":"Shanxi Province Clinical Research Center for Dermatologic and Immunologic Diseases (Rheumatic Diseases)"},{"name":"Shanxi Province Clinical Theragnostic Technology Innovation Center for Immunologic and Rheumatic Diseases"},{"name":"Shanxi Academy of Advanced Research and Innovation"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Xu","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/0265d1010","id-type":"ROR","asserted-by":"publisher"}],"name":"Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital"},{"name":"Shanxi Province Clinical Research Center for Dermatologic and Immunologic Diseases (Rheumatic Diseases)"},{"name":"Shanxi Province Clinical Theragnostic Technology Innovation Center for Immunologic and Rheumatic Diseases"},{"name":"Shanxi Academy of Advanced Research and Innovation"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-3059-0017","authenticated-orcid":false,"given":"Dan","family":"Ma","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/0265d1010","id-type":"ROR","asserted-by":"publisher"}],"name":"Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital"},{"name":"Shanxi Province Clinical Research Center for Dermatologic and Immunologic Diseases (Rheumatic Diseases)"},{"name":"Shanxi Province Clinical Theragnostic Technology Innovation Center for Immunologic and Rheumatic Diseases"},{"name":"Shanxi Academy of Advanced Research and Innovation"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2025,9,5]]},"container-title":["Expert Reviews in Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S1462399425100173","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T09:59:01Z","timestamp":1790589541000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S1462399425100173\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,5]]},"references-count":0,"alternative-id":["S1462399425100173"],"URL":"https:\/\/doi.org\/10.1017\/erm.2025.10017","relation":{},"ISSN":["1462-3994"],"issn-type":[{"value":"1462-3994","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,5]]},"assertion":[{"value":"\u00a9 The Author(s), 2025. Published by Cambridge University Press","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike licence (http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the same Creative Commons licence is used to distribute the re-used or adapted article and the original article is properly cited. The written permission of Cambridge University Press must be obtained prior to any commercial use.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}],"article-number":"e44"}}