{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T20:00:36Z","timestamp":1792699236776,"version":"4.5.0"},"reference-count":91,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T00:00:00Z","timestamp":1766966400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Expert Rev. Mol. Med."],"published-print":{"date-parts":[[2026]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Cervical cancer remains a major global health burden. Despite standard-of-care therapies, 30\u201350% of locally advanced-stage patients develop treatment resistance, leading to recurrence and mortality. While tumour-intrinsic mechanisms (e.g., DNA methylation, cancer-associated fibroblasts) explain only partial resistance heterogeneity, emerging evidence identifies the microbiome as a critical modulator of therapeutic efficacy. This review synthesizes recent advances demonstrating that vaginal microbial dysbiosis, characterized by\n                    <jats:italic>Lactobacillus iners<\/jats:italic>\n                    enrichment and\n                    <jats:italic>L. crispatus<\/jats:italic>\n                    depletion, drives resistance through lactate-mediated metabolic rewiring, immune checkpoint stabilization and drug metabolism alteration. Longitudinal studies reveal dynamic microbiome trajectories during therapy, with geographic variations (notably HIV co-infection in sub-Saharan Africa) further modulating treatment responses. We critically evaluate microbiome-based interventions, from probiotics to engineered bacteria, including synthetic biology-driven precision microbiome therapies, and establishing standardized multi-centre trial protocols. Bridging mechanistic insights with clinical application represents a paradigm shift towards microbiome-informed cervical cancer management.\n                  <\/jats:p>","DOI":"10.1017\/erm.2025.10029","type":"journal-article","created":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T05:24:27Z","timestamp":1766985867000},"update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":2,"title":["Microbiome-driven resistance in cervical cancer therapy: from mechanistic dissection to clinical translation"],"prefix":"10.1017","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-5702-0630","authenticated-orcid":false,"given":"Xiaoqi","family":"Wu","sequence":"first","affiliation":[{"name":"The Second Affiliated Hospital of Fujian University of Traditional Chinese 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