{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T16:16:59Z","timestamp":1785428219469,"version":"3.56.0"},"reference-count":56,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T00:00:00Z","timestamp":1770595200000},"content-version":"unspecified","delay-in-days":39,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Expert Rev. Mol. Med."],"published-print":{"date-parts":[[2026]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S1462399426100349_sec17\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Blastocyst formation represents an essential requirement for subsequent implantation. Successful embryo implantation depends on adequate endometrial receptivity and appropriate embryo-maternal communication. Uterus-derived extracellular vesicles (EVs), as biological nanoscale particles carrying non-coding RNAs (nc-RNAs), DNAs, proteins and lipids, play a crucial role in promoting cellular interaction\n                      <jats:underline>s<\/jats:underline>\n                      and regulating maternal-foetal dialogue.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1462399426100349_sec18\" sec-type=\"methods\">\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>This article systematically searched the PubMed database and used the following keyword combinations for literature screening : (exosome * OR \u2018extracellular vesicle\u2019) AND (uter OR blastocysti) AND (blastocyst OR embryo*).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1462399426100349_sec19\" sec-type=\"results\">\n                    <jats:title>Result<\/jats:title>\n                    <jats:p>The composition of uterus-derived EVs exhibits variation across different physiological periods and plays different roles. Compared with the proliferative phase, EVs during the peri-implantation period contain more molecules related to cell differentiation, cell cycle, cell migration and invasion, apoptosis and antioxidant activity. The EVs discovered from uterine fluid, primary human endometrial epithelial cells (EECs), endometrial stromal cell and so forth have been shown to be internalised by embryos and trophoblast cell. The cargoes carried by EVs, mainly miRNA and proteins, regulate embryonic development and invasion-related pathways or molecules, supporting blastocyst formation and implantation. Similarly, EVs collected from dysfunctional uterus have been proved to disrupt critical reproductive processes, impairing both embryo development and implantation potential.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1462399426100349_sec20\" sec-type=\"conclusions\">\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This review summarises the multiple effects of uterus-derived EVs on successful embryo implantation, including the effects on pre-implantation embryo development and embryo implantation ability.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/erm.2026.10034","type":"journal-article","created":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T09:58:43Z","timestamp":1770631123000},"update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":0,"title":["Mediating Cross-Talk: How Uterus-Derived Extracellular Vesicles Influence Early Embryo Development and Implantation"],"prefix":"10.1017","volume":"28","author":[{"given":"Qiuyu","family":"Yu","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04xy45965","id-type":"ROR","asserted-by":"publisher"}],"name":"Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Jin","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04xy45965","id-type":"ROR","asserted-by":"publisher"}],"name":"Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2464-1422","authenticated-orcid":false,"given":"Bo","family":"Zhang","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04xy45965","id-type":"ROR","asserted-by":"publisher"}],"name":"Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2026,2,9]]},"reference":[{"key":"S1462399426100349_r31","doi-asserted-by":"publisher","DOI":"10.1093\/hropen\/hoaf051"},{"key":"S1462399426100349_r6","doi-asserted-by":"publisher","DOI":"10.1042\/CS20220793"},{"key":"S1462399426100349_r3","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2018.01.059"},{"key":"S1462399426100349_r11","doi-asserted-by":"publisher","DOI":"10.1016\/j.theriogenology.2018.03.027"},{"key":"S1462399426100349_r25","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2022.12.008"},{"key":"S1462399426100349_r5","first-page":"182","article-title":"Extracellular vesicles: Roles in gamete maturation, fertilization and embryo implantation","volume":"22","author":"Machtinger","year":"2015","journal-title":"Human Reproduction Update"},{"key":"S1462399426100349_r56","doi-asserted-by":"publisher","DOI":"10.1007\/s43032-023-01448-w"},{"key":"S1462399426100349_r48","doi-asserted-by":"publisher","DOI":"10.1186\/s12958-022-01023-z"},{"key":"S1462399426100349_r13","doi-asserted-by":"publisher","DOI":"10.1186\/s40104-022-00763-7"},{"key":"S1462399426100349_r17","doi-asserted-by":"publisher","DOI":"10.1093\/biolre\/ioy263"},{"key":"S1462399426100349_r24","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aaz7070"},{"key":"S1462399426100349_r43","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcpro.2025.100942"},{"key":"S1462399426100349_r40","doi-asserted-by":"publisher","DOI":"10.1093\/molehr\/gaaa034"},{"key":"S1462399426100349_r35","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-023-01834-1"},{"key":"S1462399426100349_r19","doi-asserted-by":"publisher","DOI":"10.1016\/j.repbio.2019.06.003"},{"key":"S1462399426100349_r30","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202200677R"},{"key":"S1462399426100349_r45","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2022.146337"},{"key":"S1462399426100349_r29","doi-asserted-by":"publisher","DOI":"10.1093\/hropen\/hoaf010"},{"key":"S1462399426100349_r15","doi-asserted-by":"publisher","DOI":"10.1016\/j.theriogenology.2021.10.021"},{"key":"S1462399426100349_r49","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtn.2020.10.043"},{"key":"S1462399426100349_r21","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dead138"},{"key":"S1462399426100349_r14","doi-asserted-by":"publisher","DOI":"10.1016\/j.theriogenology.2024.12.020"},{"key":"S1462399426100349_r32","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202401728R"},{"key":"S1462399426100349_r54","first-page":"1945","article-title":"Altered microRNA profiles of extracellular vesicles secreted by endometrial cells from women with recurrent implantation failure. 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