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Globally, hepatic disorders pose a significant public health burden, frequently involving disruptions in glucose metabolism and consequent lactate buildup.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1462399426100362_sec02\" sec-type=\"methods\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This comprehensive review examines the discovery, regulatory mechanisms and pathogenic roles of lactylation in diverse liver disorders, while critically evaluating emerging lactylation-targeted therapeutics to guide future translational research.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1462399426100362_sec03\" sec-type=\"results\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Lactylation modifications play a pivotal role in various pathophysiological processes, including hepatic inflammation, liver fibrosis, ischaemic injury, tumour growth and metastasis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1462399426100362_sec04\" sec-type=\"conclusions\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Modulation of lactylation pathways, coupled with pharmacological control of lactate synthesis and shuttling, emerges as a strategic approach to liver disease therapeutics.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/erm.2026.10036","type":"journal-article","created":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T09:58:43Z","timestamp":1770631123000},"update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":1,"title":["Protein Lactylation in Liver Disease: A Comprehensive Review"],"prefix":"10.1017","volume":"28","author":[{"given":"Sipu","family":"Wang","sequence":"first","affiliation":[{"name":"Tianjin Medical University General 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